Incidence of muscle wasting in the critically ill: a prospective observational cohort study
Scientific Reports, 2023 Loss of muscle mass occurs rapidly during critical illness and negatively affects quality of life. The incidence of clinically significant muscle wasting in critically ill patients is unclear.
Ondrej Hrdy +5 more
doaj +1 more source
The bone morphogenetic protein axis is a positive regulator of skeletal muscle mass [PDF]
, 2013 Although the canonical transforming growth factor β signaling pathway represses skeletal muscle growth and promotes muscle wasting, a role in muscle for the parallel bone morphogenetic protein (BMP) signaling pathway has not been defined. We report,
Amthor +75 more
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Micro(RNA)-managing muscle wasting [PDF]
Journal of Applied Physiology, 2019 Progressive skeletal muscle wasting is a natural consequence of aging and is common in chronic and acute diseases. Loss of skeletal muscle mass and function (strength) often leads to frailty, decreased independence, and increased risk of hospitalization.
Anthony J. Sannicandro +2 more
openaire +2 more sources
Myocardial Dysfunction in an Animal Model of Cancer Cachexia [PDF]
, 2011 Aims Fatigue is a common occurrence in cancer patients regardless of tumor type or anti-tumor therapies and is an especially problematic symptom in persons with incurable tumor disease.
Crawford, Danielle +7 more
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Increased amino acid turnover and myofibrillar protein breakdown in advanced cancer are associated with muscle weakness and impaired physical function [PDF]
, 2018 Muscle wasting in cancer negatively affects physical function and quality of life. This study investigates amino acid metabolism and the association with muscle mass and function in patients with cancer.In 16 patients with advanced cancer undergoing ...
Deutz, Nicolaas E P +3 more
core +1 more source
Hypoxia Aggravates Inactivity-Related Muscle Wasting [PDF]
Frontiers in Physiology, 2018 Frontiers in physiology 9, 494 (2018).
Tadej Debevec +9 more
openaire +6 more sources
Cellular and molecular mechanisms underlying muscular dystrophy [PDF]
, 2014 The muscular dystrophies are a group of heterogeneous genetic diseases characterized by progressive degeneration and weakness of skeletal muscle. Since the discovery of the first muscular dystrophy gene encoding dystrophin, a large number of genes have ...
Kunkel, Louis M., Rahimov, Fedik
core +1 more source
Skeletal Muscle, 2022 Skeletal muscle wasting is a clinically remarkable phenotypic feature of pulmonary arterial hypertension (PAH) that increases the risk of mortality.
Guiling Xiang +7 more
doaj +1 more source
Serum Amyloid A induces toll-like receptor 2-dependent inflammatory cytokine expression and atrophy in C2C12 skeletal muscle myotubes [PDF]
, 2016 Background Skeletal muscle wasting is an important comorbidity of Chronic Obstructive Pulmonary Disease (COPD) and is strongly correlated with morbidity and mortality. Patients who experience frequent acute exacerbations of COPD (AECOPD) have more severe
Anderson, G +4 more
core +1 more source
The Proteolytic Systems of Muscle Wasting [PDF]
Recent Advances in DNA & Gene Sequences (Formerly Recent Patents on DNA & Gene Sequences), 2016 Skeletal muscle represents one of the most plastic tissues of our body thanks to the presence of heterogeneous population of myofibers that confer to skeletal muscle the functional plasticity necessary to modulate its morpho-fuctional properties in response to a wide range of external factors.
Scicchitano, Bianca Maria +2 more
openaire +2 more sources