Results 1 to 10 of about 244,000 (120)

Lack of Skeletal Effects in Mice with Targeted Disruptionof Prolyl Hydroxylase Domain 1 (Phd1) Gene Expressed in Chondrocytes

Life, 2022
The critical importance of hypoxia-inducible factor (HIF)s in the regulation of endochondral bone formation is now well established. HIF protein levels are closely regulated by the prolyl hydroxylase domain-containing protein (PHD) mediated ubiquitin ...
Weirong Xing, Destiney Larkin, Sheila Pourteymoor, William Tambunan, Gustavo A. Gomez, Elaine K. Liu, Subburaman Mohan   +6 more
doaj   +1 more source

STING regulates peripheral nerve regeneration and colony stimulating factor 1 receptor (CSF1R) processing in microglia

iScience, 2021
Summary: Inflammatory responses are crucial for regeneration following peripheral nerve injury (PNI). PNI triggers inflammatory responses at the site of injury.
Giulio Morozzi, Julian Rothen, Gauthier Toussaint, Katrina De Lange, Katrin Westritschnig, Arno Doelemeyer, Vanessa Pitiot Ueberschlag, Peter Kahle, Christian Lambert, Michael Obrecht, Nicolau Beckmann, Veronique Ritter, Moh Panesar, Daniela Stauffer, Isabelle Garnier, Matthias Mueller, Danilo Guerini, Caroline Gubser Keller, Judith Knehr, Guglielmo Roma, Michael Bidinosti, Sophie Brachat, Frederic Morvan, Mara Fornaro   +23 more
doaj   +1 more source

Harpagoside attenuates local bone Erosion and systemic osteoporosis in collagen-induced arthritis in mice

BMC Complementary Medicine and Therapies, 2022
Background Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease that causes local bone erosion and systemic osteoporosis. Harpagoside (HAR), an iridoid glycoside, has various pharmacological effects on pain, arthritis, and inflammation.
Ju-Young Kim, Yoon-Hee Cheon, Sung-Jun Ahn, Sung Chul Kwak, Chong Hyuk Chung, Chang Hoon Lee, Myeung Su Lee   +6 more
doaj   +1 more source

Mice with Targeted Knockout of Tetraspanin 3 Exhibit Reduced Trabecular Bone Mass Caused by Decreased Osteoblast Functions

Cells, 2022
Tetraspanin3 (TSPAN3) was identified as a binding partner of claudin11 (CLDN11) in osteoblasts and other cell types. Mice with targeted disruption of Cldn11 exhibited trabecular bone mass deficit caused by reduced bone formation and osteoblast function ...
Weirong Xing, Sheila Pourteymoor, Chandrasekhar Kesavan, Gustavo A. Gomez, Subburaman Mohan   +4 more
doaj   +1 more source

Repeated mild traumatic brain injury impairs fracture healing in male mice

BMC Research Notes, 2022
Objectives The goal of this study was to evaluate the long-term impact of repeated (r) mild traumatic brain injury (mTBI) on the healing of fractures in a mouse model.
Chandrasekhar Kesavan, Charles Rundle, Subburaman Mohan   +2 more
doaj   +1 more source

Prolyl Hydroxylase Domain-Containing Protein 3 Gene Expression in Chondrocytes Is Not Essential for Bone Development in Mice

Cells, 2021
We previously showed that conditional disruption of the Phd2 gene in chondrocytes led to a massive increase in long bone trabecular bone mass. Loss of Phd2 gene expression or inhibition of PHD2 activity by a specific inhibitor resulted in a several-fold ...
Weirong Xing, Sheila Pourteymoor, Gustavo A. Gomez, Yian Chen, Subburaman Mohan   +4 more
doaj   +1 more source

Development of an Animal Model for Traumatic Brain Injury Augmentation of Heterotopic Ossification in Response to Local Injury

Biomedicines, 2023
Heterotopic ossification (HO) is the abnormal growth of bone in soft connective tissues that occurs as a frequent complication in individuals with traumatic brain injury (TBI) and in rare genetic disorders.
Chandrasekhar Kesavan, Gustavo A. Gomez, Sheila Pourteymoor, Subburaman Mohan   +3 more
doaj   +1 more source

Global and Conditional Disruption of the Igf-I Gene in Osteoblasts and/or Chondrocytes Unveils Epiphyseal and Metaphyseal Bone-Specific Effects of IGF-I in Bone

Biology, 2023
To evaluate the relative importance of IGF-I expression in various cell types for endochondral ossification, we quantified the trabecular bone at the secondary spongiosa and epiphysis of the distal femur in 8–12-week-old male mice with a global knockout ...
Weirong Xing, Chandrasekhar Kesavan, Sheila Pourteymoor, Subburaman Mohan   +3 more
doaj   +1 more source

WNT16 Regulation of the Articular Chondrocyte Phenotype in Mice

Life, 2023
The anabolic effects of WNT16 on osteoblasts are well established, however, little is known regarding the role of WNT16 in chondrocytes. In this study, we evaluated Wnt16 expression and its biological effects on mouse articular chondrocytes (ACs), since ...
Subburaman Mohan, Shelia Pourteymoor, Chandrasekhar Kesavan   +2 more
doaj   +1 more source

Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion

Biology, 2023
We previously demonstrated that mice with targeted deletion of the leucine repeat rich kinase 1 (Lrrk1) gene were osteopetrotic due to the failure of osteoclasts to resorb bone.
Sandi Shen, Mingjue Si, Canjun Zeng, Elaine K. Liu, Yian Chen, Jean Vacher, Haibo Zhao, Subburaman Mohan, Weirong Xing   +8 more
doaj   +1 more source