Results 41 to 50 of about 5,165,603 (261)

Enhanced Bone Formation in Segmental Defect Healing Using 3D Printed Scaffolds Containing Bone Marrow Stromal Cells and Small Molecules Targeting Chondrogenesis and Osteogenesis

Biomedicines
Background/Objectives: Nonunion bone healing results from a critical size defect that fails to bridge a bone injury to produce bony union. Novel approaches are critical for refining therapy in clinically challenging bone injuries, but the complex and ...
Charles H. Rundle, Sheila Pourteymoor, Enoch Lai, Chandrasekhar Kesavan, Subburaman Mohan   +4 more
doaj   +1 more source

A segmental defect adaptation of the mouse closed femur fracture model for the analysis of severely impaired bone healing

Animal Models and Experimental Medicine, 2020
Objective To better characterize nonunion endochondral bone healing and evaluate novel therapeutic approaches for critical size defect healing in clinically challenging bone repair, a segmental defect model of bone injury was adapted from the three‐point
Amandeep Kaur, Subburaman Mohan, Charles H. Rundle   +2 more
doaj   +1 more source

Organisational downsizing and musculoskeletal problems in employees: a prospective study [PDF]

, 2001
Objectives: To study the association between organisational downsizing and subsequent musculoskeletal problems in employees and to determine the association with changes in psychosocial and behavioural risk factors.
Vahtera, J., Ferrie, J.E., Pentti, J., Hemingway, H., Kivimäki, M.   +4 more
core  

Identifying the most important confounders when assessing the association between low-grade systemic inflammation and musculoskeletal pain:A modified Delphi study

, 2021
OBJECTIVE: The association between low-grade systemic inflammation and musculoskeletal pain may be influenced by multiple factors. However, little is known about the relative importance of these factors, and few studies account for them.
Coppieters, Michel W; id_orcid, Coppieters, Michel W, Lutke Schipholt, Ivo J, Scholten-Peeters, Gwendolyne G M; id_orcid, Scholten-Peeters, Gwendolyne G M, Scholten-Peeters, Gwendolyne GM, Koop, Meghan A, Lutke Schipholt, Ivo J; id_orcid   +7 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Assessment and determinants of health care utilization among patients with musculoskeletal conditions undergoing outpatient rehabilitation in Germany [PDF]

, 2011
The overall objective of this doctoral thesis is to address some of the conditions necessary to routinely perform alongside economic evaluations of rehabilitation programs.
Sabariego, Carla
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

A disease register for ME/CFS: Report of a pilot study [PDF]

, 2011
Background: The ME/CFS Disease Register is one of six subprojects within the National ME/CFS Observatory, a research programme funded by the Big Lottery Fund and sponsored by Action for ME.
Pheby Derek, Valerie Featherstone, Curran, Monica, Nacul Luis, Howe, Amanda, Luis Nacul, Nacul, Luis, José Carlos de Carvalho Leite, Lacerda Eliana, Fayyaz Shagufta, Shagufta Fayyaz, Leite, José Carlos de Carvalho, Leite, José, Featherstone, Valerie, Pheby, Derek, Lacerda, Eliana, Sakellariou, Dikaios, Leite José, Campion, Peter, Sakellariou Dikaios, Featherstone, Valerie A., Drachler, Maria, Poland Fiona, Fiona Poland, Featherstone Valerie, Drachler Maria, Derek Pheby, Maria de Lourdes Drachler, Maria Drachler, Peter Campion, Curran Monica, José Leite, Howe Amanda, Dikaios Sakellariou, Fayyaz, Shagufta, Monica Curran, Drachler, Maria de Lourdes, Campion Peter, Eliana Lacerda, Poland, Fiona, Amanda Howe   +40 more
core   +1 more source

Real‐World Longitudinal Data on the Impact of Hydroxychloroquine Blood Level Monitoring on Lupus Outcomes: Results of a Prospective Longitudinal Cohort Study

Arthritis Care &Research, EarlyView.
Objective Hydroxychloroquine (HCQ) is a cornerstone therapy in systemic lupus erythematosus (SLE), but the weight‐based dosing does not account for clinical factors that can introduce individual variability in drug metabolism and clearance. We leveraged longitudinal data from a prospective SLE cohort to identify clinical factors that predict ...
Jay J. Patel, Fauzia Hollangel, Caroline Packee, Amita Kapoor, Brad Rovin, Nathalie Costedoat‐Chalumeau, Shivani Garg   +6 more
wiley   +1 more source

Safety of Prescription Nonsteroidal Anti‐inflammatory Drugs in Adults With Inflammatory Bowel Disease: Data From a Large Administrative Claims Cohort

Arthritis Care &Research, EarlyView.
Objective The concern that nonsteroidal anti‐inflammatory drugs (NSAIDs) may precipitate flares of inflammatory bowel disease (IBD) has limited their use in managing musculoskeletal symptoms in those with IBD, but safety data are mixed. Methods This retrospective cohort study included patients with IBD aged at least 18 years from Optum's deidentified ...
Adam S. Mayer, Rui Xiao, Meenakshi Bewtra, Michael D. George, Pamela F. Weiss   +4 more
wiley   +1 more source