Results 81 to 90 of about 5,165,603 (261)

Rationale, design and methods of the Study of Work and Pain (SWAP): a cluster randomised controlled trial testing the addition of a vocational advice service to best current primary care for patients with musculoskeletal pain (ISRCTN 52269669) [PDF]

, 2014
Background Musculoskeletal pain is a major contributor to short and long term work absence. Patients seek care from their general practitioner (GP) and yet GPs often feel ill-equipped to deal with work issues.
Foster, N.E., Sarah A Lawton, Gwenllian Wynne-Jones, Hay, Elaine M, Bishop, A., Foster, Nadine E, Jowett, Sue, Lewis, M, Foster, Nadine, Foster, NE, Sanders, T., Annette Bishop, Lawton, SA, van der Windt, Danielle, Burton, A.K., Hay, EM, Gail Sowden, Sowden, Gail, Sanders, Tom, Sanders, T, van der Windt, D., Burton, A Kim, Sue Jowett, Wynne-Jones, Gwenllian, SWAP study team, Jowett, S, Wynne-Jones, G., Burton, A. Kim, Lewis, Martyn, Jowett, S., Lawton, Sarah A, Chris Main, Jowett, Sue; id_orcid, Tom Sanders, Wynne-Jones, G, Hay, Elaine, Danielle van der Windt, A Kim Burton, Lawton, S.A., Nadine E Foster, Bishop, Annette, van der Windt, D, Main, C., Lewis, M., Main, Chris J., Sowden, G, Lawton, Sarah, Bishop, A, Hay, E.M., Martyn Lewis, Elaine M Hay, Main, Chris, Sowden, G.   +52 more
core   +2 more sources

Engagement Patterns With an Artificial Intelligence Health Coach for Systemic Sclerosis Self‐Management: A Mixed Methods Study

Arthritis Care &Research, EarlyView.
Objective To evaluate utility of an artificial intelligence (AI) health coach for systemic sclerosis (SSc) self‐management and identify patterns associated with participant engagement. Methods We conducted a mixed methods study in which an AI health coach, powered by a large language model (LLM), was used to support self‐management for SSc.
Nirali Shah, Melanie Morris, Cristina Daraban, Sophia Johnson, Susan L. Murphy   +4 more
wiley   +1 more source

Expression of Phosphomimetic OSTM1-T328E/S329D Variant Partially Restores Bone Resorption Defect in LRRK1-Deficient Mice

Biology
LRRK1 is essential for osteoclast-mediated bone resorption, and loss of LRRK1 function causes osteopetrosis in mice and humans. However, the mechanisms by which LRRK1 regulates osteoclast activity remain incompletely defined.
Anakha Udayakumar, Yian Chen, Haibo Zhao, Subburaman Mohan, Weirong Xing   +4 more
doaj   +1 more source

Occupational Musculoskeletal Disorders in Europe: Impact, Risk factors and Preventive Regulations [PDF]

The aim of this article is to characterize musculoskeletal disorders (MSDs) in EU working population according to available Eurostat data, to identify relevant risk factors and to refer existing legislation and standards to prevent MSDs.
José Miquel Cabeças
core  

From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis

Arthritis Care &Research, EarlyView.
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss, Judith A. Smith, Robert A. Colbert, Erin Treemarcki, Michael H. Weisman, Walter P. Maksymowych, Hermine I. Brunner, for the Childhood Arthritis and Rheumatology Research Alliance, Spondyloarthritis Research and Treatment Network, and Pediatric Rheumatology Collaborative Study Group Advisory Council   +9 more
wiley   +1 more source

Mitochondrial protein deacetylation by SIRT3 in osteoclasts promotes bone resorption with aging in female mice

Molecular Metabolism
Objectives: The mitochondrial deacetylase sirtuin-3 (SIRT3) is necessary for the increased bone resorption and enhanced function of mitochondria in osteoclasts that occur with advancing age; how SIRT3 drives bone resorption remains elusive.
Kimberly K. Richardson, Gareeballah Osman Adam, Wen Ling, Aaron Warren, Adriana Marques-Carvalho, Jeff D. Thostenson, Kimberly Krager, Nukhet Aykin-Burns, Stephanie D. Byrum, Maria Almeida, Ha-Neui Kim   +10 more
doaj   +1 more source

Upper-extremity musculoskeletal disorders: how many cases can be prevented? Estimates from the COSALI cohort

Scandinavian Journal of Work, Environment & Health, 2020
OBJECTIVE: This study aimed to estimate the proportion and number of incident upper-extremity musculoskeletal disorders (UEMSD) cases attributable to occupational risk factors in a working population.
Aboubakari Nambiema, Julie Bodin, Natacha Fouquet, Sandrine Bertrais, Susan Stock, Agnès Aublet-Cuvelier, Alexis Descatha, Bradley Evanoff, Yves Roquelaure   +8 more
doaj   +1 more source

Understanding the Burden of Orofacial Involvement and Patient Treatment Preferences in Systemic Sclerosis: Results From a Large International Survey

Arthritis Care &Research, EarlyView.
Objective Orofacial manifestations are significantly impactful in patients with systemic sclerosis (SSc) yet remain understudied, with no dedicated clinical guidelines to inform their management. Methods An international online survey comprised38 questions addressing orofacial manifestations of SSc, including patients’ confidence in their treating ...
Eleni Deligianni, Lee Shapiro, Deana Gibbs, Zsuzsanna H. McMahan, Michael Hughes   +4 more
wiley   +1 more source

Maintained physical activity and physiotherapy in the management of distal upper limb pain – a protocol for a randomised controlled trial (the Arm Pain Trial) [PDF]

, 2014
Background Upper limb pain is a common cause of disability, demand for health care and lost work time. It is more likely to become persistent if it is accompanied by poor mental health, tendency to somatise, and negative beliefs concerning health and
Jones, Gareth T, Coggon, D., Macfarlane, G.J., Burton, K., Palmer, Keith T., McNamee, P., Jones, Gareth T., Coggon, David, Walker-Bone, Karen, Macfarlane, Gary J, Mertens, K., McCabe, C., McConnachie, A., Macfarlane, Gary J., Palmer, Keith T, Walker-Bone, K., McCabe, Candy, Heine, P.J., Burton, Kim, Mertens, Kathrin, Heine, Peter J, McNamee, Paul, Burton, A. Kim, McConnachie, Alex, Palmer, K. T., Palmer, K.T., Heine, Peter J., Coggon, D. (David), Dr., Jones, G.T.   +28 more
core   +1 more source

Association of Elevated Platelets and C‐Reactive Protein With Severe Disease and Poor Survival in Systemic Sclerosis

Arthritis Care &Research, EarlyView.
Objective Elevated C‐reactive protein (CRP) levels in systemic sclerosis (SSc) have been linked with severe disease and worse survival, but the role of platelet levels remains unclear. This study examined whether elevated platelet levels, CRP levels, or both are associated with disease severity, progression, and survival in SSc.
Brian S. Lee, Shufeng Li, Srijana Davuluri, Jennifer Lee, Lorinda Chung   +4 more
wiley   +1 more source