Results 1 to 10 of about 664,651 (329)

Biological effects of gamma-ray radiation on tulip (Tulipa gesneriana L.) [PDF]

PeerJ, 2022
Tulip, being an important ornamental plant, generally requires lengthy and laborious procedures to develop new varieties using traditional breeding methods requires.
Yirui Li, Li Chen, Xiaodie Zhan, Liang Liu, Feihong Feng, Zihua Guo, Dan Wang, Hao Chen   +7 more
doaj   +2 more sources

Development of a new quantitative structure–activity relationship model for predicting Ames mutagenicity of food flavor chemicals using StarDrop™ auto-Modeller™

Genes and Environment, 2021
Background Food flavors are relatively low molecular weight chemicals with unique odor-related functional groups that may also be associated with mutagenicity. These chemicals are often difficult to test for mutagenicity by the Ames test because of their
Toshio Kasamatsu, Airi Kitazawa, Sumie Tajima, Masahiro Kaneko, Kei-ichi Sugiyama, Masami Yamada, Manabu Yasui, Kenichi Masumura, Katsuyoshi Horibata, Masamitsu Honma   +9 more
doaj   +1 more source

In vivo and in vitro mutagenicity of perillaldehyde and cinnamaldehyde

Genes and Environment, 2021
Background Perillaldehyde and cinnamaldehyde are natural substances found in plants that are used as flavoring ingredients. Due to the α,β-unsaturated aldehydes in their structures, these compounds are expected to be DNA reactive. Indeed, several reports
Masamitsu Honma, Masami Yamada, Manabu Yasui, Katsuyoshi Horibata, Kei-ichi Sugiyama, Kenichi Masumura   +5 more
doaj   +1 more source

Mutant p53K120R expression enables a partial capacity to modulate metabolism

Frontiers in Genetics, 2022
The TP53 tumor suppressor gene is one of the most studied gene in virtue of its ability to prevent cancer development by regulating apoptosis, cell cycle arrest, DNA repair, autophagy and senescence.
Paola Monti, Silvia Ravera, Andrea Speciale, Irena Velkova, Giorgia Foggetti, Paolo Degan, Gilberto Fronza, Paola Menichini   +7 more
doaj   +1 more source

Detection of in vivo mutagenicity in rat liver samples using error-corrected sequencing techniques

Genes and Environment, 2023
Background Mutagenicity, the ability of chemical agents to cause mutations and potentially lead to cancer, is a critical aspect of substance safety assessment for protecting human health and the environment.
Kazuki Izawa, Masataka Tsuda, Takayoshi Suzuki, Masamitsu Honma, Kei-ichi Sugiyama   +4 more
doaj   +1 more source

Coordinated Cut and Bypass: Replication of Interstrand Crosslink-Containing DNA

Frontiers in Cell and Developmental Biology, 2021
DNA interstrand crosslinks (ICLs) are covalently bound DNA lesions, which are commonly induced by chemotherapeutic drugs, such as cisplatin and mitomycin C or endogenous byproducts of metabolic processes.
Qiuzhen Li, Kata Dudás, Gabriella Tick, Lajos Haracska   +3 more
doaj   +1 more source

Genotoxicity assessment of food-flavoring chemicals used in Japan

Toxicology Reports, 2022
We assessed the genotoxicity of 30 food-flavoring chemicals used in Japan that have not been investigated before. These 30 food-flavoring chemicals have representative chemical structures belonging to 18 chemical classes.
Masamitsu Honma, Masami Yamada, Manabu Yasui, Katsuyoshi Horibata, Kei-ichi Sugiyama, Kenichi Masumura   +5 more
doaj   +1 more source

Effect of episomally encoded DNA polymerases on chemically induced mutagenesis at the hisG46 target in Ames test

Genes and Environment, 2020
Background The standard Ames test strains owe their high sensitivity to chemical and physical mutagens to the episomal Y-family DNA polymerase RI encoded by the mucAB operon. The S. typhimurium test strains carry also another related samAB operon on a 60-
Petr Grúz, Masatomi Shimizu, Kei-ichi Sugiyama, Masami Yamada, Masamitsu Honma   +4 more
doaj   +1 more source

Comparison of the frequencies of ENU-induced point mutations in male germ cells and inherited germline mutations in their offspring

Genes and Environment, 2021
Background Gene mutations induced in germ cells may be transmitted to the next generation and cause adverse effects such as genetic diseases. Certain mutations may result in infertility or death in early development.
Kenichi Masumura, Tomoko Ando, Naomi Toyoda-Hokaiwado, Akiko Ukai, Takehiko Nohmi, Masamitsu Honma   +5 more
doaj   +1 more source

Bisphenol-A reduces DNA methylation after metabolic activation

Genes and Environment, 2022
Bisphenol-A (BPA) is an important environmental contaminant with adverse health effects suspected to be mediated through epigenetic mechanisms.
Kei-ichi Sugiyama, Mawo Kinoshita, Petr Grúz, Toshio Kasamatsu, Masamitsu Honma   +4 more
doaj   +1 more source