Results 91 to 100 of about 45,003 (206)
AAV Vectors, Insertional Mutagenesis, and Cancer
Molecular Therapy, 2007 By now we have all heard a lot about retroviral vectors and cancer, but other types of vectors have typically been left out of these discussions. However, results presented at the recent American Society of Gene Therapy meeting and just published in Science1 show that this is a subject that goes beyond retroviruses, hematopoietic cells, and gamma C ...
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PLoS ONE, 2019 The systematic identification of regulatory elements that control gene expression remains a challenge. Genetic screens that use untargeted mutagenesis have the potential to identify protein-coding genes, non-coding RNAs and regulatory elements, but their
Bhaven B Patel +5 more
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Use of integrase-minus lentiviral vector for transient expression [PDF]
, 2012 Objective: Lentivirus-derived vectors are among the most promising viral vectors for gene therapy which is currently available, but their use in clinical practice is limited due to associated risk of insertional mutagenesis.
Azadeh, H. +5 more
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Overexpression of kermit/dGIPC is associated with lethality in Drosophila melanogaster
Brazilian Journal of Medical and Biological Research, 2011 Insertional mutagenesis is an important tool for functional genomics in Drosophila melanogaster. The insertion site in the KG00562 mutant fly line has been mapped to the CG8709 (herein named DmLpin) locus and to the 3’ of kermit (also called dGIPC). This
G.B. Pereira +4 more
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Role of LRR-RLKS in stress response and developmental processes through systematic K.O. analysis in rice [PDF]
, 2010 The function of a small number of Leucine-Rich Repeat Receptor-Like Kinase (LRR-RLK) genes has been studied, mostly in Arabidopsis thaliana. They are involved in several important biological processes, including development, resistance/defence and ...
Dievart, Anne +6 more
core
Retroviruses and Insertional Mutagenesis
Cold Spring Harbor Symposia on Quantitative Biology, 1985 R, Jaenisch +4 more
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Molecular genetics of development studied in the transgenic mouse. [PDF]
, 1989 Gruss, P., Westphal, H.
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A PCR-based method for isolation of genomic DNA flanking a known DNA sequence [PDF]
, 1999 We describe a simple PCR-based method for the isolation of genomic DNA that lies adjacent to a known DNA sequence. The method is based on the directional cloning of digested genomic DNA into the multiple cloning site of a pUC-based plasmid to generate a ...
Boulter, CA, Natarajan, D
core
Development of Ac- and Ds-tagged starter lines for large-scale transposon-mutagenesis in tomato. [PDF]
PLoS OneKumari A +4 more
europepmc +1 more source