Results 31 to 40 of about 45,003 (206)
Plant Methods, 2017 Background Random insertional mutagenesis of Chlamydomonas reinhardtii using drug resistance cassettes has contributed to the generation of tens of thousands of transformants in dozens of labs around the world. In many instances these insertional mutants
Steve V. Pollock +6 more
doaj +1 more source
HERVs, transposons and human diseases : part II [PDF]
, 2013 Part 1 and part 3 of the article can be found through this link : https://www.um.edu.mt/library/oar//handle/123456789/12961 https://www.um.edu.mt/library/oar//handle/123456789/13132Part 2 of the article.
Baldacchino, Sandra, Grech, Alfred
core +2 more sources
Insertional mutagenesis in the zoonotic pathogen Chlamydia caviae.
PLoS ONE, 2019 The ability to introduce targeted genetic modifications in microbial genomes has revolutionized our ability to study the role and mode of action of individual bacterial virulence factors.
Kimberly Filcek +6 more
doaj +1 more source
EBioMedicine, 2018 Insertional mutagenesis is an important risk with all genetically modified cell therapies, including chimeric antigen receptor (CAR)-T cell therapy used for hematological malignancies.
Motoharu Hamada +21 more
doaj +1 more source
Frontiers in Microbiology, 2023 Microalgae are a large group of organisms that can produce various useful substances through photosynthesis. Microalgae need to be genetically modified at the molecular level to become “Chassis Cells” for food, medicine, energy, and environmental ...
Xiaobing Hu +6 more
doaj +1 more source
A Review of Genetic Transfer Therapy Trials from a Regulatory Perspective for the Scientific Understanding [PDF]
, 2013 The present work reviews the safety and efficacy concerns of the Recombinant DNA Advisory Committee (RAC) regarding Gene Transfer Therapy (GTT) clinical trials.
Olguin, Arturo
core +2 more sources
Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection
Life Science Alliance, 2019 Targeted integration of a tumor-reactive T-cell receptor into the TRAC locus using CRISPR-Cas9 and AAV6 redirects primary human T cells against tumor cells in vitro and in vivo .
Julian J Albers +14 more
doaj +1 more source
Large-scale insertional mutagenesis of a coleopteran stored grain pest, the red flour beetle Tribolium castaneum, identifies embryonic lethal mutations and enhancer traps [PDF]
, 2009 Background Given its sequenced genome and efficient systemic RNA interference response, the red flour beetle Tribolium castaneum is a model organism well suited for reverse genetics.
Jochen Trauner +8 more
core +1 more source
PLoS Computational Biology, 2018 Haploid cells are increasingly used for screening of complex pathways in animal genomes. Hemizygous mutations introduced through viral insertional mutagenesis can be directly selected for phenotypic changes.
Giulio Di Minin +2 more
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Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation
Cell Reports, 2016 To identify genes and signaling pathways that initiate Neurofibromatosis type 1 (NF1) neurofibromas, we used unbiased insertional mutagenesis screening, mouse models, and molecular analyses.
Jianqiang Wu +22 more
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