Results 21 to 30 of about 136,223 (377)

Acute Toxicity and DNA Instability Induced by Exposure to Low Doses of Triclosan and Phthalate DEHP, and Their Combinations, in vitro

Frontiers in Genetics, 2021
Triclosan (TCS) is an antimicrobial agent widely used in personal care products (PCP) and the di-(2-ethyl hydroxy-phthalate) (DEHP) is a chemical compound derived from phthalic acid, used in medical devices and plastic products with polyvinyl chloride ...
Nathalia de Assis Aguilar Duarte, Lindiane Eloisa de Lima, Flora Troina Maraslis, Michael Kundi, Emilene Arusievicz Nunes, Gustavo Rafael Mazzaron Barcelos   +5 more
doaj   +1 more source

Food Mutagens [PDF]

The Journal of Nutrition, 2003
Several lines of evidence indicate that diet and dietary behaviors can contribute to human cancer risk. One way that this occurs is through the ingestion of food mutagens. Sporadic cancers result from a gene-environment interactions where the environment includes endogenous and exogenous exposures.
Radoslav, Goldman, Peter G, Shields
openaire   +2 more sources

LightGBM: An Effective and Scalable Algorithm for Prediction of Chemical Toxicity-Application to the Tox21 and Mutagenicity Data Sets

Journal of Chemical Information and Modeling, 2019
Machine learning algorithms have attained widespread use in assessing the potential toxicities of pharmaceuticals and industrial chemicals because of their faster-speed and lower-cost compared to experimental bioassays.
Jin Zhang, Daniel Mucs, U. Norinder, Fredrik Svensson   +3 more
semanticscholar   +1 more source

In-silico Predictive Mutagenicity Model Generation Using Supervised Learning Approaches [PDF]

, 2011
With the advent of High Throughput Screening techniques, it is feasible to filter possible leads from a mammoth chemical space that can act against a particular target and inhibit its action.
Abhik Seal, Abhik Seal, Anurag Passi, OSDD Consortium, UC Abdul Jaleel   +4 more
core   +2 more sources

Mutagenicity and Lung Toxicity of Smoldering vs. Flaming Emissions from Various Biomass Fuels: Implications for Health Effects from Wildland Fires

Environmental Health Perspectives, 2018
Background: The increasing size and frequency of wildland fires are leading to greater potential for cardiopulmonary disease and cancer in exposed populations; however, little is known about how the types of fuel and combustion phases affect these ...
Yong Ho Kim, Yong Ho Kim, S. Warren, Q. Krantz, Charly J. King, R. Jaskot, William T. Preston, B. J. George, M. Hays, M. Landis, M. Higuchi, D. DeMarini, M. I. Gilmour   +12 more
semanticscholar   +1 more source

Genotoxicity assessment of piperitenone oxide: an in vitro and in silico evaluation [PDF]

, 2017
Piperitenone oxide, a natural flavouring agent also known as rotundifolone, has been studied for the genotoxicity assessment by an integrated in vitro and in silico experimental approach, including the bacterial reverse mutation assay, the micronucleus ...
Abete, Lorena, Barile, Fabio, Bozovic, Mijat, DI GIACOMO, Silvia, DI SOTTO, Antonella, Izzo, Angelo A, Mazzanti, Gabriela, Parisi, Olga A, Ragno, Rino, Vitalone, Annabella   +9 more
core   +1 more source

Screening for Ames mutagenicity of food flavor chemicals by (quantitative) structure-activity relationship

Genes and Environment, 2020
Background (Quantitative) Structure-Activity Relationship ((Q)SAR) is a promising approach to predict the potential adverse effects of chemicals based on their structure without performing toxicological studies.
Masamitsu Honma, Airi Kitazawa, Toshio Kasamatsu, Kei-ichi Sugiyama   +3 more
doaj   +1 more source

Seagrass Posidonia oceanica (L.) Delile as a marine biomarker: A metabolomic and toxicological analysis [PDF]

, 2018
A human-made environmental disaster due to the shipwrecked of Costa Concordia cruise vessel on the Tuscan Island of Giglio (Italy) coast and the possible pollutants release has been feared, so requiring the activation of removal operations and the ...
Agostini, Ardizzone, Beck, Bitam, Boudouresque, Cannac, Dalla Via, Del Moral, Del Serrone, Di Sotto, Di Sotto, Di Sotto, Di Sotto, Dumay, Díaz, Farah, Fitzpatrick, Fonseca, Francour, Gacia, Gacia, Grace, Greco, Heglmeier, Jones, Kuo, Lassauque, Maestrini, Maggi, Moglia, Mollica, Montefalcone, Nicoletti, Nicoletti, Pérez, Reich, Richir, Ruiz, Sager, Toniolo   +39 more
core   +1 more source

Improvement of quantitative structure–activity relationship (QSAR) tools for predicting Ames mutagenicity: outcomes of the Ames/QSAR International Challenge Project

Mutagenesis, 2018
The International Conference on Harmonization (ICH) M7 guideline allows the use of in silico approaches for predicting Ames mutagenicity for the initial assessment of impurities in pharmaceuticals. This is the first international guideline that addresses
M. Honma, A. Kitazawa, A. Cayley, R. Williams, C. Barber, T. Hanser, R. Saiakhov, S. Chakravarti, G. Myatt, K. Cross, E. Benfenati, G. Raitano, O. Mekenyan, P. Petkov, Cecilia Bossa, R. Benigni, C. Battistelli, A. Giuliani, O. Tcheremenskaia, Christine DeMeo, U. Norinder, Hiromi Koga, Ciloy Jose, N. Jeliazkova, N. Kochev, Vesselina Paskaleva, Chihae Yang, Pankaj R. Daga, Robert D Clark, J. Rathman   +29 more
semanticscholar   +1 more source

Mutagenicity comparison of nine bioselenocompounds in three Salmonella typhimurium strains

Toxicology Reports, 2018
Selenium (Se) is an essential element in animals but becomes severely toxic when the amount ingested exceeds the adequate intake level. It is known that the toxicological effects of Se are highly dependent on its chemical form.
Hironori Kobayashi, Noriyuki Suzuki, Yasumitsu Ogra   +2 more
doaj   +1 more source