Results 221 to 230 of about 11,554 (309)

Protease‐mediated maturation of M‐PMV reverse transcriptase into a functional heterodimer

Protein Science, Volume 35, Issue 2, February 2026.
Abstract Reverse transcriptase (RT) of retroviruses orchestrates viral replication, yet its structural diversity remains poorly understood. Well‐studied RTs, such as those from HIV‐1, murine leukemia virus, and avian myeloblastosis virus, were characterized decades ago, but less prominent retroviruses have escaped detailed analysis.
Marina Kapisheva, Petra Junková, Ondřej Vaněk, Zuzana Jalovcová, Ivana Křížová, Alžběta Dostálková, Michaela Rumlová   +6 more
wiley   +1 more source

A Simple Framework for Collaborative Development of Predictive Models Trained on Proprietary Data. [PDF]

J Chem Inf Model
Rodríguez-Belenguer P, Amberg A, Bringezu F, Frericks M, Hemmerich J, Monecke P, Oberhauser N, Trairatphisan P, Pastor M.   +8 more
europepmc   +1 more source

Proximal Pulmonary Artery Stiffening as a Biomarker of Cardiopulmonary Aging

Aging Cell, Volume 25, Issue 2, February 2026.
Mouse models revealed age‐associated increased circumferential stiffness of the proximal pulmonary artery that was associated with reorientation of collagen and decreased function of the lung and right ventricle. Age‐related transcriptional changes were indicative of senescence, ECM turnover, TGFβ signaling, and altered intercellular signaling among ...
Ruben De Man, Zhongyu Cai, Pramath Doddaballapur, Nicole Guerrera, Alexandria Regan, Liqin Lin, Erica Schwarz, Aurelien Justet, Nebal S. Abu Hussein, Jack Di Palo, Cristina Cavinato, Micha Sam B. Raredon, Paul M. Heerdt, Inderjit Singh, Xiting Yan, Min‐Jong Kang, Danielle R. Bruns, Patty J. Lee, George Tellides, Jay D. Humphrey, Naftali Kaminski, Abhay B. Ramachandra, Edward P. Manning   +22 more
wiley   +1 more source

Structure-mutagenicity relationships on quinoline and indole analogues in the Ames test. [PDF]

Genes Environ
Kurakami M, Hakura A, Sato R, Kawade A, Yamagata T, Koyama N, Kakiuchi D, Asakura S.   +7 more
europepmc   +1 more source

Clinical effectiveness, safety, and viral mutagenicity of oral favipiravir for COVID-19: results from a community-based, open-label, randomized Phase III trial. [PDF]

Antimicrob Agents Chemother
Tate M, Illingworth CJR, MacGregor G, Cunningham L, Divers L, McCartney E, Paterson L, Kelly C, Shaw A, Perkins JS, Silva V, Holland P, Dalton C, Carmichael S, Douglas E, Surtees P, Scott JT, Berry C, Vattipally S, Da Silva Filipe A, Tong L, Gunson R, GETAFIX trial co-investigators, McInnes IB, Jones R, Thomson E, Blyth KG.   +26 more
europepmc   +1 more source

Nuclear DNA of plastid origin (NUPTs), neglected driver of genome variation and evolutionary innovation

The Plant Journal, Volume 125, Issue 3, February 2026.
Significance Statement Contrary to expectation, NUPTs do not necessarily have a deleterious or ultimately neutral impact, nor are they necessarily purged from the genome. Instead, they can proliferate and eventually become fixed, generating new and novel genes, gene regions and regulatory elements, thereby significantly contributing to plant nuclear ...
Lorenzo Carretero‐Paulet, Juan Pablo Marczuk‐Rojas, Aaron Gálvez‐Salido   +2 more
wiley   +1 more source

A Comprehensive Review of Robinetin: Distribution, Biological Activity and Pharmacokinetic Parameters. [PDF]

Int J Mol Sci
Jakimiuk K.
europepmc   +1 more source

Peer review of the pesticide risk assessment of the active substance paraffin oil (CAS 97862‐82‐3, chain lengths C16–C28)

EFSA Journal, Volume 24, Issue 2, February 2026.
Abstract The conclusions of the European Food Safety Authority (EFSA) following the peer review of the initial risk assessments carried out by the competent authorities of the rapporteur Member State Greece and co‐rapporteur Member State France for the pesticide active substance paraffin oil (CAS 97862‐82‐3) are reported. The context of the peer review
European Food Safety Authority (EFSA), Fernando Álvarez, Maria Arena, Domenica Auteri, Sofia Batista Leite, Amarela Becirovic, Marco Binaglia, Anna Federica Castoldi, Arianna Chiusolo, Angelo Colagiorgi, Mathilde Colas, Federica Crivellente, Chloe De Lentdecker, Isabella De Magistris, Mark Egsmose, Gabriella Fait, Franco Ferilli, German Giner Santonja, Varvara Gouliarmou, Katrin Halling, Alessio Ippolito, Frederique Istace, Dimitra Kardassi, Aude Kienzler, Anna Lanzoni, Roberto Lava, Renata Leuschner, Alberto Linguadoca, Mariano Lopez Romano, Jochem Louisse, Christopher Lythgo, Oriol Magrans, Iris Mangas, Andrea Mioč, Ileana Miron, Tunde Molnar, Laura Padovani, Vincenzo Padricello, Martina Panzarea, Juan Manuel Parra Morte, Simone Rizzuto, Miguel Santos, Rositsa Serafimova, Rachel Sharp, Csaba Szentes, Anne Theobald, Manuela Tiramani, Giorgia Vianello, Laura Villamar‐Bouza   +48 more
wiley   +1 more source

Diazirines Beyond Photoaffinity Labeling: A Comprehensive Overview of Applications in Biological Sciences, Materials Chemistry, and NMR‐Spectroscopy

Angewandte Chemie, Volume 138, Issue 4, 22 January 2026.
Diazirines are three‐membered, nitrogen‐containing heterocycles that decompose under light or heat to generate carbenes. For the past two decades, they have served mainly as minimally invasive tags in photoaffinity labeling (PAL). More recently, their value as versatile carbene precursors has been recognized.
Dominik Schnalzer, Viktor Savic, Clemens Cziegler, Michael Schnürch, Marko D. Mihovilovic   +4 more
wiley   +2 more sources