Results 251 to 260 of about 11,554 (309)
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Mutagenicity tests with griseofulvin
Mutation Research/Genetic Toxicology, 1979Griseofulvin was studied for its ability to induce structural chromosomal aberrations in germ and somatic cells of the male mouse. It was also tested for its capacity to produce his+ revertants in Salmonella typhimurium. All tests yielded negative results, whereas highly significant effects were recorded in control assays with thio-TEPA.
Leonard, A +4 more
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Mutagenicity testing with Salmonella microsome test
Archives of Toxicology, 1980This in vitro mutagenicity test system comprises five different strains of S. typhimurium as target cells with the rat liver S-9 fraction and appropriate co-factors for metabolic activation of the chemical tested. The bacterial tester strains detect both mutations induced by base pair substitutions and intercalation (frame shift mutations).
Greim, H.A. +3 more
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Small numbers in mutagenicity tests
Archives of Toxicology, 1977Experimental control material for statistical analysis of the results of the micronuclei test in the mouse (NMRI strain) and the Chinese hamster and for the host-mediated assay in the mouse (NMRI strain) using auxotrophic bacterial strains are presented. The binomial distribution of the micronuclei makes it possible to analyse the sample size according
A, Grafe, J, Vollmar
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Mutagenicity testing in industry
Archives of Toxicology, 1977The aims of authorities, university and industrial scientists are outlined. The prime feature remains: How important are the achieved results for estimating the mutagenic risk to humans? The various methods available for the testing of chemical substances for mutagenicity are compared.
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1985
This article deals primarily with the practical aspects of mutagen testing with yeast. Equipment necessary for a laboratory where mutagen testing with yeast is performed, and the most commonly used media, are listed. Some general procedures are described and, finally, for those who have little experience with work of this kind, a precise protocol is ...
F, Eckardt, W, Siede
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This article deals primarily with the practical aspects of mutagen testing with yeast. Equipment necessary for a laboratory where mutagen testing with yeast is performed, and the most commonly used media, are listed. Some general procedures are described and, finally, for those who have little experience with work of this kind, a precise protocol is ...
F, Eckardt, W, Siede
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Mutagenicity testing with Drosophila
Archives of Toxicology, 1980The fruit fly, Drosophila melanogaster with its well known genetics is used to detect newly induced mutations in germ cells. Assay systems are available to determine point mutations, chromosome aberrations and nondisjunction. The sex-linked recessive lethal test is of primary practical importance, because it can detect mutagens with and without ...
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Mutagenicity Testing with Drosophila Melanogaster
1985The fruit fly, Drosophila melanogaster, is the eukaryote most often used to detect mutations in germ cells. There are several facts which make this insect an attractive test system for screening chemical compounds for mutagenic activity. The short generation time of only 10 days, low cost of culture media, easy breeding of large numbers of animals with
F E, Würgler, U, Graf
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Mutagenicity testing on ethylenethiourea
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1977Abstract A potential mutagenicity of ethylenethiourea (ETU) was investigated by a series of experiments including microbial, cytogenetic and dominant-lethal studies. The microbial studies revealed a weak mutagenic activity of ETU for Salmonella strain TA1535.
S. Teramoto +6 more
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Mutagenicity testing with eukaryotic microorganisms
Archives of Toxicology, 1980The different genetic end-points which can be tested to detect genotoxicity of chemicals in fungi and especially in the yeast Saccharomyces cerevisiae are described. They include reversion and forward mutation, mitochondrial deletions and point mutations, mitotic or meiotic intra- and intergenic recombination, chromosomal non-disjunction and aneuploidy.
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Assessment of Mutagenicity Tests
1980Using the short term tests it is possible to evaluate whether or not chemicals are potential mutagens. The mutagenic hazards for man, however, have to be established by tests on mammals in vivo. Where reproducible mutagenicity findings exist with conclusive tests, consideration of the possible threshold doses, together with benefit/risk equations ...
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