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A combined testing protocol approach for mutagenicity testing
Mutation Research/Environmental Mutagenesis and Related Subjects, 1979The antischistosomal agent, hycanthone methanesulfonate (HMS), was employed to illustrate the utility of carrying out several mutagenicity tests in a single concurrent animal experiment. Several commonly used procedures that were successfully integrated into a multiple testing protocol included (1) metaphase analysis in bone marrow, (2) micronucleus ...
T H, Connor +3 more
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Mutagenicity testing of some medicinal herbs
Journal of Ethnopharmacology, 1987AbstractExtracts of four brands of a Pakistani local medicine called naswar and six indigenous herbs commonly used as medicine in children were tested for their ability to induce mutations to prototrophy in Salmonella typhimurium tester strains TA98, TA100, TA1535, and TA1537.
S, Riazuddin, M M, Malik, A, Nasim
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1985
The wx locus assay in maize pollen grains may be conducted using one of two chronic treatment regimens and under in situ conditions. Solutions of a test chemical can be applied to the soil of plants grown in pots or to the nutrient medium of plants grown under hydroponic culture. Under in situ conditions, test plots may be constructed in the field, and
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The wx locus assay in maize pollen grains may be conducted using one of two chronic treatment regimens and under in situ conditions. Solutions of a test chemical can be applied to the soil of plants grown in pots or to the nutrient medium of plants grown under hydroponic culture. Under in situ conditions, test plots may be constructed in the field, and
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Cytogenetic techniques in mutagenicity testing
Agents and Actions, 1973Both in vivo and in vitro methodologies have uses as cytogenetic test systems for mutagenicity testing. The in vivo methods are certainly the choice as the primary test system, except perhaps in the case of viruses and some biologicals. When an in vitro method is used anaphase offers some advantages as greater speed and ease of observation, the ...
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Statistical problems in mutagenicity tests
Archives of Toxicology, 1977Everyone involved in planning and carrying out biological experiments has to concern himself with statistical methods. Thus, descriptive statistics (e. g. calculation of the mean) help to present results briefly and comprehensively and, in addition, statistical test procedures permit decisions to be made even in an uncertain situation.
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Bacterial Mutagenicity Assays: Test Methods
2011The most widely used assays for detecting chemically induced gene mutations are those employing bacteria. The plate incorporation assay using various Salmonella typhimurium LT2 and E. coli WP2 strains is a short-term bacterial reverse mutation assay specifically designed to detect a wide range of chemical substances capable of causing DNA damage ...
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Granuloma pouch assay for mutagenicity testing
Archives of Toxicology, 1980The Granuloma Pouch Assay (GPA) is an animal model in which mutagenic and carcinogenic effects of a testcompound can be detected in rapidly dividing fibroblasts of a granulation tissue in adult male rats. Growth of this tissue was initiated with a small amount of croton oil at the inside wall of a subcutaneous air pouch on the back of the animals.
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Mutagenicity research and testing in Sweden
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis, 1975A survey is given of Swedish legislation for control of chemicals in the environment. Although no direct legal requirements for mutagenicity testing of chemicals exist at present in Sweden, such requirements can be enforced within the existing laws. Testing and research in chemical mutagenicity are especially performed at the Environmental Toxicology ...
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Microorganisms as test systems for mutagenicity
Archiv f�r Toxikologie, 1971The mutagenic activity of different compounds in bacterial mutagenicity test systems has been investigated. The systems used include back-mutations to prototrophy in auxotrophic strains of Serratia marcescens and forward mutations to galactose prototrophy in a phenotypic galactose negative strain of Escherichia coli.
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Mutagenicity – Relevance of Short-Term Tests
Oncology, 1980Short-term tests measuring diverse biological activities of compounds, such as mutagenicity, have been proposed as prescreening methods to determine potential carcinogenicity. High correlations of up to 90% have been found for response in short-term tests versus response in long-term carcinogenicity assays, e.g.
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