Entamoeba histolytica “mutator” strain with a high rate of genetic mutations assists the elucidation of drug resistance mechanisms [PDF]
Microbiology SpectrumIn drug discovery, target identification and elucidation of resistance mechanisms are essential. The pathogen strains resistant to a compound of interest are useful for these purposes.
Yumiko Saito-Nakano +7 more
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Tissue-specific responses to TFAM and mtDNA copy number manipulation in prematurely ageing mice [PDF]
eLifeSomatic mitochondrial DNA (mtDNA) mutations are implicated as important drivers of ageing and age-related diseases. Their pathological effect can be counteracted by increasing the absolute amount of wild-type mtDNA via moderately upregulating TFAM, a ...
Laura Sophie Kremer +8 more
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Frontiers in Plant Science, 2022 Mutator-like transposable elements (MULEs) represent a unique superfamily of DNA transposons as they can capture host genes and cause higher frequency of mutations in some eukaryotes.
Dongying Gao +4 more
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OTA Based Mem-capacitor Validation and Implementation Using Commercially Available IC [PDF]
International Journal of Electronics and Telecommunications, 2023 This paper discusses a mem-capacitor circuit which is based on two MO-OTA along with a multiplier and 4 passive elements. This circuit is a charge-controlled memcapacitor emulator which is independent of any memristor also it consists the feature of ...
Chandra Shankar +3 more
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Mutator mutations enhance tumorigenic efficiency across fitness landscapes. [PDF]
PLoS ONE, 2009 BACKGROUND:Tumorigenesis requires multiple genetic changes. Mutator mutations are mutations that increase genomic instability, and according to the mutator hypothesis, accelerate tumorigenesis by facilitating oncogenic mutations.
Robert A Beckman
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Frontiers in Cellular and Infection Microbiology, 2021 Elucidation of the mechanisms of drug resistance in malaria parasites is crucial for combatting the emergence and spread of resistant parasites, which can be achieved by tracing resistance-associated mutations and providing useful information for drug ...
Mie Ikeda +4 more
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Mitochondrial DNA mutations in mutator mice confer respiration defects and B-cell lymphoma development. [PDF]
PLoS ONE, 2013 Mitochondrial DNA (mtDNA) mutator mice are proposed to express premature aging phenotypes including kyphosis and hair loss (alopecia) due to their carrying a nuclear-encoded mtDNA polymerase with a defective proofreading function, which causes ...
Takayuki Mito +9 more
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A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans
eLife, 2020 piRNAs play a critical role in the regulation of transposons and other germline genes. In Caenorhabditis elegans, regulation of piRNA target genes is mediated by the mutator complex, which synthesizes high levels of siRNAs through the activity of an RNA ...
Kevin I Manage +12 more
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Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci. [PDF]
PLoS Genetics, 2018 In C. elegans, efficient RNA silencing requires small RNA amplification mediated by RNA-dependent RNA polymerases (RdRPs). RRF-1, an RdRP, and other Mutator complex proteins localize to Mutator foci, which are perinuclear germline foci that associate ...
Celja J Uebel +6 more
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Frontiers in Microbiology, 2022 Fitness and mutability are the primary traits of living organisms for adaptation and evolution. However, their quantitative linkage remained largely deficient.
Zehui Lao +3 more
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