Results 21 to 30 of about 12,851 (183)
Volatility of Mutator Phenotypes at Single Cell Resolution. [PDF]
PLoS Genetics, 2015 Mutator phenotypes accelerate the evolutionary process of neoplastic transformation. Historically, the measurement of mutation rates has relied on scoring the occurrence of rare mutations in target genes in large populations of cells.
Scott R Kennedy +5 more
doaj +1 more source
Mutation Spectra and the Neutrality of Mutations [PDF]
Australian Journal of Biological Sciences, 1974 The effect of amino acid replacements on enzyme function was studied in the tJ-galactosidase of Escherichia coli. Mutants possessing 50% or less of normal enzyme activity were isolated and examined. Of 733 amino acid substitutions calculated to have occurred, only 11 reduced tJ-galactosidase activity below 50 %.
openaire +2 more sources
Functional Analysis of Cancer-Associated DNA Polymerase ε Variants in Saccharomyces cerevisiae
G3: Genes, Genomes, Genetics, 2018 DNA replication fidelity relies on base selectivity of the replicative DNA polymerases, exonucleolytic proofreading, and postreplicative DNA mismatch repair (MMR). Ultramutated human cancers without MMR defects carry alterations in the exonuclease domain
Stephanie R. Barbari +3 more
doaj +1 more source
Colorectal cancer prognosis: is it all mutation, mutation, mutation? [PDF]
Gut, 2005 For the 500 000 new cases of colorectal cancer in the world each year, identification of patients with a worse prognosis and those who are more likely to respond to treatment is a challenge. There is an increasing body of evidence correlating genetic mutations with outcome in tumours derived from human colorectal cancer cohorts.
Hassan, AB, Paraskeva, C
openaire +2 more sources
Mutational spectrum drives the rise of mutator bacteria.
PLoS Genetics, 2013 Understanding how mutator strains emerge in bacterial populations is relevant both to evolutionary theory and to reduce the threat they pose in clinical settings.
Alejandro Couce +2 more
doaj +1 more source
Mutator dynamics in sexual and asexual experimental populations of yeast
BMC Evolutionary Biology, 2011 Background In asexual populations, mutators may be expected to hitchhike with associated beneficial mutations. In sexual populations, recombination is predicted to erode such associations, inhibiting mutator hitchhiking.
Gazzara Matthew R +2 more
doaj +1 more source
Frontiers in Microbiology, 2012 We recently showed that a prophage-like Streptococcus pyogenes chromosomal island (SpyCI) controls DNA mismatch repair (MMR) and other repair functions in M1 genome strain SF370 by dynamic excision and reintegration into the 5’ end of mutL in response to
Julie eScott +5 more
doaj +1 more source
Mutator suppression and escape from replication error-induced extinction in yeast. [PDF]
PLoS Genetics, 2011 Cells rely on a network of conserved pathways to govern DNA replication fidelity. Loss of polymerase proofreading or mismatch repair elevates spontaneous mutation and facilitates cellular adaptation.
Alan J Herr +7 more
doaj +1 more source
Selection on mutators is not frequency-dependent
eLife, 2019 The evolutionary fate of mutator mutations – genetic variants that raise the genome-wide mutation rate – in asexual populations is often described as being frequency (or number) dependent.
Yevgeniy Raynes, Daniel Weinreich
doaj +1 more source