Results 11 to 20 of about 12,851 (183)

Estimating the Rate of Mutation to a Mutator Phenotype

Axioms, 2023
A mutator is a variant in a population of organisms whose mutation rate is higher than the average mutation rate in the population. For genetic and population dynamics reasons, mutators are produced and survive with much greater frequency than anti ...
Isaac Vázquez-Mendoza, Erika E. Rodríguez-Torres, Mojgan Ezadian, Lindi M. Wahl, Philip J. Gerrish   +4 more
doaj   +2 more sources

Chloroplast- and mitochondrion-specific random C-to-T mutagenesis for forward genetics of organelle genomes. [PDF]

Plant J
Significance Statement This study provides a chloroplast‐ and mitochondrion‐specific random mutagenesis tool specialized for C‐to‐T substitutions, enabling organelle genome‐focused forward genetic analysis. By utilizing this tool, we can screen for organelle genome‐associated traits and isolate novel mutations that are not only of physiological ...
Kosaka N, Harada Y, Nakazato I, Okuno M, Itoh T, Tsutsumi N, Arimura SI.   +6 more
europepmc   +2 more sources

Analysis of Mutagenesis in the Escherichia coli tdk Gene: The Nucleoid Protein HNS Is Required for a Dramatic Cisplatin-Induced Hotspot. [PDF]

Environ Mol Mutagen
ABSTRACT We demonstrate the utility of the tdk reporter gene system, by showing its ability to not only analyze mutational hotspots, but also to allow the analysis of both weak and strong mutator or mutagen effects. It can detect large and small insertions and deletions, as well as base substitutions.
Sorensen D, Mata T, Sridharan A, Mathew M, Sagastume E, Sutkin N, Douglas K, Daniel M, Hung A, Garmash A, Hsieh A, Ortega JE, Miller JH.   +12 more
europepmc   +2 more sources

Mutators Enhance Adaptive Micro-Evolution in Pathogenic Microbes

Microorganisms, 2022
Adaptation to the changing environmental conditions experienced within a host requires genetic diversity within a microbial population. Genetic diversity arises from mutations which occur due to DNA damage from exposure to exogenous environmental ...
Kylie J. Boyce
doaj   +1 more source

Mutations in Putative Mutator Genes of Mycobacterium tuberculosis Strains of the W-Beijing Family

Emerging Infectious Diseases, 2003
Alterations in genes involved in the repair of DNA mutations (mut genes) result in an increased mutation frequency and better adaptability of the bacterium to stressful conditions. W-Beijing genotype strains displayed unique missense alterations in three
Mina Ebrahimi Rad, Pablo Bifani, Carlos Martin, Kristin Kremer, Sofia Samper, Jean Rauzier, Barry N. Kreiswirth, Jesus Blazquez, Marc Jouan, Dick van Soolingen, Brigitte Gicquel   +10 more
doaj   +1 more source

Alternative oxidase causes cell type- and tissue-specific responses in mutator mice

Life Science Alliance, 2023
Expression of the alternative oxidase in mtDNA mutator mice improves their blood phenotype but enhances inflammatory and stress responses in skeletal muscle.
Lilli Ikonen, Sini Pirnes-Karhu, Swagat Pradhan, Howard T Jacobs, Marten Szibor, Anu Suomalainen   +5 more
doaj   +1 more source

Piecing Together How Peroxiredoxins Maintain Genomic Stability

Antioxidants, 2018
Peroxiredoxins, a highly conserved family of thiol oxidoreductases, play a key role in oxidant detoxification by partnering with the thioredoxin system to protect against oxidative stress.
James D. West, Trevor J. Roston, Joseph B. David, Kristin M. Allan, Matthew A. Loberg   +4 more
doaj   +1 more source

A spatial mutation model with increasing mutation rates

Journal of Applied Probability, 2023
AbstractWe consider a spatial model of cancer in which cells are points on the d-dimensional torus $\mathcal{T}=[0,L]^d$ , and each cell with $k-1$ mutations acquires a kth mutation at rate $\mu_k$ . We assume that the mutation rates $\mu_k$ are increasing, and we find the asymptotic waiting time for the first cell to acquire k mutations as the ...
Brian Chao, Jason Schweinsberg
openaire   +6 more sources

Mutational landscape of yeast mutator strains [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Deficiencies in genome maintenance genes (so-called mutator genes) result in increased mutagenesis that impacts cell evolvability. How the mutational processes drive the evolution of genome structure is not well understood. Here, we used high-throughput sequencing to characterize the mutation events (from punctual mutations to ...
Alexandre, Serero, Claire, Jubin, Sophie, Loeillet, Patricia, Legoix-Né, Alain G, Nicolas   +4 more
openaire   +2 more sources

The Odyssey of the Ancestral Escherich Strain through Culture Collections: an Example of Allopatric Diversification

mSphere, 2018
More than a century ago, Theodor Escherich isolated the bacterium that was to become Escherichia coli, one of the most studied organisms. Not long after, the strain began an odyssey and landed in many laboratories across the world.
M. Desroches, G. Royer, D. Roche, M. Mercier-Darty, D. Vallenet, C. Médigue, K. Bastard, C. Rodriguez, O. Clermont, E. Denamur, J.-W. Decousser   +10 more
doaj   +1 more source