Results 51 to 60 of about 12,851 (183)
PLoS Genetics, 2018 Mitochondrial DNA (mtDNA) mutations cause severe maternally inherited syndromes and the accumulation of somatic mtDNA mutations is implicated in aging and common diseases.
Colby L Samstag +6 more
doaj +1 more source
Probing the Cancer Mutational Landscape of KMT2 Regulatory Subunits
The FASEB Journal, Volume 40, Issue 7, 15 April 2026.Pipeline to characterize the KMT2 cancer mutational landscape starts with querying genomic databases (top left) for mutations mapping to ASH2L, RbBP5, WDR5, and DPY‐30. Subsequent steps include the expression of these mutants in cell (bottom left), their systemic purification and biochemical characterization using isothermal titration calorimetry ...
Sabrina Grégoire +9 more
wiley +1 more source
Advanced Science, Volume 13, Issue 20, 9 April 2026.A miniaturized deaminase SsdAtox was scanned with AlphaFold to identify DNA binding pocket hot spots. Site‐saturation mutagenesis at gatekeeper residue K31 yielded ten‐fold activity enhancement. Trinity Screen, an E. coli‐based three‐in‐one platform selecting for high activity and reduced double‐strand breaks, enabled combinatorial evolution at DNA ...
Ryeo Gang Son +2 more
wiley +1 more source
Frontiers in Microbiology, 2019 Adaptive laboratory evolution (ALE) is used to find causal mutations that underlie improved strain performance under the applied selection pressure. ALE studies have revealed that mutator populations tend to outcompete their non-mutator counterparts ...
Minjeong Kang +15 more
doaj +1 more source
Post-translational decrease in respiratory chain proteins in the Polg mutator mouse brain. [PDF]
PLoS ONE, 2014 Mitochondrial DNA damage is thought to be a causal contributor to aging as mice with inactivating mutations in polymerase gamma (Polg) develop a progeroid phenotype.
David N Hauser +4 more
doaj +1 more source
Mutator Circuit for Memcapacitor Emulator Using Operational Transconductance Amplifiers
Elektronika ir ElektrotechnikaIn recent years, interest in memelements, including memcapacitors, has increased significantly following the realisation of memristors. This paper presents the design and implementation of a memcapacitor circuit based on operational transconductance ...
Mustafa Konal, Fırat Kacar
doaj +1 more source
ChemistrySelect, Volume 11, Issue 14, 13 April 2026.ABSTRACT Antimicrobial resistance (AMR) has emerged as one of the most critical global health challenges, undermining the clinical efficacy of existing antibiotics and threatening modern therapeutic strategies. The ongoing misuse and overuse of antimicrobial agents have accelerated the evolution of resistant bacterial strains and parasites ...
Subham Kumar Vishwakarma +2 more
wiley +1 more source
Acta Obstetricia et Gynecologica Scandinavica, Volume 105, Issue 4, Page 568-574, April 2026.It is expected that the relugolix estetrol combination RE4W will enable women to control their fertility and prevent menstrual cycle related problems, while offering a smooth transition through perimenopause into the postmenopause and decrease the risk of breast cancer.
Herjan J. T. Coelingh Bennink +9 more
wiley +1 more source
Effects of calorie restriction on the lifespan and healthspan of POLG mitochondrial mutator mice.
PLoS ONE, 2017 Mitochondrial DNA (mtDNA) mutations are thought to have a causative role in age-related pathologies. We have shown previously that mitochondrial mutator mice (PolgD257A/D257A), harboring a proofreading-deficient version of the mtDNA polymerase gamma ...
Shinichi Someya +6 more
doaj +1 more source