Results 71 to 80 of about 12,851 (183)
BMC Biology, 2004 Background DNA polymerase ε (Pol ε) is essential for S-phase replication, DNA damage repair and checkpoint control in yeast. A pol2-Y831A mutation leading to a tyrosine to alanine change in the Pol ε active site does not cause growth defects and confers ...
Pavlov Youri I +3 more
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Brazilian Journal of Medical and Biological Research, 1997 Two different pathogenetic mechanisms are proposed for colorectal cancers. One, the so-called "classic pathway", is the most common and depends on multiple additive mutational events (germline and/or somatic) in tumor suppressor genes and oncogenes ...
A.K. Fuzikawa +4 more
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Genetics and Molecular Biology, 2006 The TK6 lymphoblastoid cell line is known to be mismatch repair (MMR) and p53 proficient. Deficiency in MMR results in a mutator phenotype characterized by microsatellite instability (MSI) and increased hprt mutant frequency (MF).
Flávio Monteiro Ayres +3 more
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Are There Mutator Polymerases?
The Scientific World Journal, 2003 DNA polymerases are involved in different cellular events, including genome replication and DNA repair. In the last few years, a large number of novel DNA polymerases have been discovered, and the biochemical analysis of their properties has revealed a ...
Miguel Garcia-Diaz +4 more
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Proceedings of the American Mathematical Society, 1989 The author observes that if k is an oriented knot in the three-sphere and \(k'\) is obtained from k by reversing its orientation, then the connected sums \(k+k\) and \(k+k'\) are mutants of each other. For appropriate choices of k this observation yields pairs of mutant knots which are not concordant or have nonisomorphic Alexander modules.
openaire +2 more sources
A new conceptual framework for investigating complex genetic disease
Frontiers in Genetics, 2015 Some common diseases are known to have an inherited component, however their population- and familial-incidence patterns do not conform to any known monogenic Mendelian pattern of inheritance and instead they are currently much better explained if an ...
Shobbir eHussain
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BMC Plant Biology, 2009 Background Inter-specific hybridization occurs frequently in plants, which may induce genetic and epigenetic instabilities in the resultant hybrids, allopolyploids and introgressants.
Xu Chunming +8 more
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BMC Genomics, 2009 Background For three decades the Mutator system was thought to be exclusive of plants, until the first homolog representatives were characterized in fungi and in early-diverging amoebas earlier in this decade.
Pereira Gonçalo AG +5 more
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