Results 1 to 10 of about 26,541 (200)

The expression of Mutl Protein Homolog 1 (MLH1) and Muts Homolog 2 (MSH2) in colorectal carcinoma: An immunohistochemical study

Indian Journal of Pathology and Microbiology
Background: The development of colorectal carcinoma is a complicated multistep process that involves the accumulation of mutations in tumor suppressor genes and oncogenes.
Eshita Garg, Manisha Sharma, Manas Madan, Gurleen Kaur, Karamjit S Gill, Ishaan Khanna   +5 more
doaj   +3 more sources

Human MutY Homolog, a DNA Glycosylase Involved in Base Excision Repair, Physically and Functionally Interacts with Mismatch Repair Proteins Human MutS Homolog 2/Human MutS Homolog 6 [PDF]

Journal of Biological Chemistry, 2002
Adenines mismatched with guanines or 7,8-dihydro-8-oxo-deoxyguanines that arise through DNA replication errors can be repaired by either base excision repair or mismatch repair. The human MutY homolog (hMYH), a DNA glycosylase, removes adenines from these mismatches. Human MutS homologs, hMSH2/hMSH6 (hMutSalpha), bind to the mismatches and initiate the
Yesong, Gu, Antony, Parker, Teresa M, Wilson, Haibo, Bai, Dau-Yin, Chang, A-Lien, Lu   +5 more
openaire   +3 more sources

Promoter methylation of the hMLH1 gene and protein expression of human mutL homolog 1 and human mutS homolog 2 in resected esophageal squamous cell carcinoma [PDF]

The Journal of Thoracic and Cardiovascular Surgery, 2005
Aberrant expression of mismatch repair genes, such as human mutL homolog 1 (hMLH1) and human mutS homolog 2 (hMSH2), are common in some human cancers, and promoter methylation is believed to inactivate expression of hMLH1. We investigated whether promoter methylation is involved in loss of hMLH1 protein and whether aberrant expression of hMLH1 and ...
Ching, Tzao, Han-Sui, Hsu, Guang-Huan, Sun, Hsiao-Lei, Lai, Hsiou-Lei, Lai, Yi-Ching, Wang, Ho-Jui, Tung, Cheng-Ping, Yu, Yeung-Leung, Cheng, Shih-Chun, Lee   +9 more
openaire   +3 more sources

Analysis of the expression level and methylation of tumor protein p53, phosphatase and tensin homolog and mutS homolog 2 in N-methyl-N-nitrosourea-induced thymic lymphoma in C57BL/6 mice

Oncology Letters, 2017
Tumorigenesis is often caused by somatic mutation or epigenetic changes in genes that regulate aspects of cell death, proliferation and survival. Although the functions of multiple tumor suppressor genes have been well studied in isolation, how these genes cooperate during the progression of a single tumor remains unclear in numerous cases. The present
Xueyun, Huo, Zhenkun, Li, Shuangyue, Zhang, Changlong, Li, Meng, Guo, Jing, Lu, Jianyi, Lv, Xiaoyan, Du, Zhenwen, Chen   +8 more
openaire   +4 more sources

Mismatch repair proteins play a role in ATR activation upon temozolomide treatment in MGMT-methylated glioblastoma

Scientific Reports, 2022
The methylation status of the O6-methylguanine methyltransferase (MGMT) gene promoter has been widely accepted as a prognostic biomarker for treatment with the alkylator, temozolomide (TMZ). In the absence of promoter methylation, the MGMT enzyme removes
Sachita Ganesa, Amrita Sule, Ranjini K. Sundaram, Ranjit S. Bindra   +3 more
doaj   +2 more sources

Andrias davidianus Ranavirus (ADRV) Genome Replicate Efficiently by Engaging Cellular Mismatch Repair Protein MSH2

Viruses, 2022
As nucleocytoplasmic large DNA viruses, replication of ranaviruses (genus Ranavirus, family Iridoviridae) involves a series of viral and host proteins.
Fei Ke, Renbao Wang, Zihao Wang, Qiya Zhang   +3 more
doaj   +2 more sources

Characterization of a novel MSH2 variant in Lynch syndrome: clinical data and complementary bioinformatics assessment [PDF]

Einstein (São Paulo)
Objective To describe the clinical characteristics and perform a multi-step bioinformatics evaluation of the pathogenicity of NM_000251.3(MSH2):c.1894_1898del (p.Ile633Lysfs*9), an MSH2 germline variant detected in a family with Lynch syndrome. Methods
Anisse Marques Chami, Thalia Rodrigues de Souza Zózimo, Carolina Guimarães Ramos Matosinho, Agnaldo Lopes da Silva-Filho, Maria Raquel Santos Carvalho, Letícia da Conceição Braga   +5 more
doaj   +2 more sources

Nrf2 overexpression increases risk of high tumor mutation burden in acute myeloid leukemia by inhibiting MSH2

Cell Death and Disease, 2021
Nuclear factor erythroid 2-related factor 2 (Nrf2, also called NFE2L2) plays an important role in cancer chemoresistance. However, little is known about the role of Nrf2 in tumor mutation burden and the effect of Nrf2 in modulating DNA mismatch repair ...
Ping Liu, Dan Ma, Ping Wang, Chengyun Pan, Qin Fang, Jishi Wang   +5 more
doaj   +2 more sources

Expression of PD-L1 in Microsatellite Instability High Tumours: A Retrospective Study [PDF]

Journal of Clinical and Diagnostic Research, 2023
Introduction: Microsatellite Instability (MSI) is the hallmark of Lynch syndrome/Constitutional Mismatch Repair Deficiency (CMMRD) and is also found in many sporadic cancers like colorectal cancer, endometrial, gastric, small intestine, urothelial ...
Dinisha Einstien, Gayathri Devi Thanigaimani, KS Mouleeswaran, A Prathiba, G Sarumathy, John Vergilin   +5 more
doaj   +2 more sources

Mismatch Repair Protein Deficiency and Its Relationship with Clinicopathological Factors in Endometrial Cancer: A Retrospective Study. [PDF]

J Cancer
Background: The present study aimed to determine the frequency of mismatch repair (MMR) protein expression loss, as identified using immunohistochemistry (IHC), in tumor cells of endometrial cancer patients and the potential associations between this ...
Aytekin O, Cesur N, Gozel S, Karsli SE, Tokalioglu AA, Kilic F, Cuylan ZF, Selcuk I, Comert GK, Erdogan F, Turan T.   +10 more
europepmc   +2 more sources