Results 31 to 40 of about 26,541 (200)

Comparison of screening strategies for Lynch syndrome in patients with newly diagnosed endometrial cancer: a prospective cohort study in China

Cancer Communications, 2019
Background The prevalence of Lynch syndrome and screening strategies for this disorder in Chinese patients with endometrial cancer have seldom been investigated.
Xiaopei Chao, Lei Li, Ming Wu, Shuiqing Ma, Xianjie Tan, Sen Zhong, Yalan Bi, Jinghe Lang   +7 more
doaj   +1 more source

Immunophenotypic Evaluation of Mismatch Repair Proteins in Various Solid Tumours: A Cross-sectional Study from a Tertiary Care Cancer Centre in Rajasthan, India [PDF]

Journal of Clinical and Diagnostic Research
Introduction: Mismatch Repair (MMR) proteins are essential in correcting DeoxyRibo Nucleic Acid (DNA) replication errors, including point mutations, to maintain genetic stability.
Neha Sethi, Maneesh K Vijay, Shikha Goyal, Kusha Sharma, Praveena Vyas, Shweta Bansal, Haraina Kiran, Abha Mathur   +7 more
doaj   +1 more source

DNA repair mechanisms and gametogenesis [PDF]

, 2001
In mammals, there is a complex and intriguing relationship between DNA repair and gametogenesis. DNA repair mechanisms are involved not only in the repair of different types of DNA damage in developing germline cells, but ...
Baarends, W.M. (Willy), Grootegoed, J.A. (Anton), Laan, R. (Roald) van der   +2 more
core   +2 more sources

Analysis of human MutS homolog 2 missense mutations in patients with colorectal cancer

Oncology Letters, 2018
Germline mutations of DNA mismatch repair gene human MutS homolog 2 (hMSH2) are associated with hereditary nonpolyposis colorectal cancer (HNPCC). A total of one-third of these mutations are missense mutations.
Xiao-mei Zhang, Senqing Chen, Jun Yu, Yuan-ying Zhang, Min-Yi Lv, Ming Zhu   +5 more
semanticscholar   +1 more source

Meiotic double strand breaks repair in sexually reproducing eukaryotes: We are not all equal. [PDF]

, 2012
The defining event of meiosis is prophase-I, during which the maternal and paternal chromosome find each other in the nucleus, pair, and align in a process called “synapses of the homologues”. Their faithful segregation during the first meiotic division (
Barchi, M, La Volpe, A
core   +1 more source

The Molecular Analysis for Therapy Choice (NCI-MATCH) Trial: Lessons for Genomic Trial Design

Journal of the National Cancer Institute, 2020
Background The proportion of tumors of various histologies that may respond to drugs targeted to molecular alterations is unknown. NCI-MATCH, a collaboration between ECOG-ACRIN Cancer Research Group and the National Cancer Institute, was initiated to ...
K. Flaherty, R. Gray, A. Chen, Shuli Li, D. Patton, S. Hamilton, P. M. Williams, E. Mitchell, A. Iafrate, J. Sklar, L. Harris, L. McShane, L. Rubinstein, David J Sims, M. Routbort, Brent Coffey, T. Fu, J. Zwiebel, R. Little, D. Marinucci, R. Catalano, Rick Magnan, W. Kibbe, C. Weil, J. V. Tricoli, B. Alexander, Shaji K. Kumar, G. Schwartz, F. Meric-Bernstam, C. Lih, W. McCaskill-Stevens, P. Caimi, N. Takebe, V. Datta, C. Arteaga, J. Abrams, R. Comis, P. O'dwyer, B. Conley   +38 more
semanticscholar   +1 more source

Early-Onset/Young-Onset Colorectal Carcinoma: A Comparative Analysis of Morphological Features and Biomarker Profile

Cureus, 2023
Introduction Colorectal carcinoma (CRC) is one of the most common cancers that involve the human body. Young-onset CRC (YO-CRC) or early-onset CRC (EO-CRC) is defined as CRC that develops before the age of 50 years, as opposed to CRC that is diagnosed ...
A. Hashmi, M. Aslam, Khushbakht Rashid, Abrahim H Ali, T. Dowlah, U. Malik, Shamail Zia, Sunder Sham, Fazail Zia, M. Irfan   +9 more
semanticscholar   +1 more source

Exploring nucleo-cytoplasmic large DNA viruses in Tara Oceans microbial metagenomes [PDF]

, 2013
Nucleo-cytoplasmic large DNA viruses (NCLDVs) constitute a group of eukaryotic viruses that can have crucial ecological roles in the sea by accelerating the turnover of their unicellular hosts or by causing diseases in animals. To better characterize the
Acinas, Silvia G., Bork, Peer, Claverie, Jean-Michel, Clerissi, Camille, de Vargas, Colomban, Department of Applied Biological Sciences (DBIT), Vrije Universiteit Brussel, Brussels, Belgium, Department of Applied Biological Sciences (DBIT), Vrije Universiteit Brussel, Brussels, Belgium, Department of Applied Biological Sciences (DBIT), Vrije Universiteit Brussel, Brussels, Belgium, Desdevises, Yves, Faust, Karoline, Ferrera, Isabel, Grimsley, Nigel, Hingamp, Pascal, Jaillon, Olivier, Kandels-Lewis, Stefanie, Karsenti, Eric, Lima-Medez, Gipsi, Moreau, Hervé, Not, Fabrice, Ogata, Hiroyuki, Pesant, Stéphane, Poulain, Julie, Raes, Jeroen, Sarmento, Hugo, Subirana, Lucie, Sunagawa, Shinichi, Villar, Emilie, Wincker, Patrick   +27 more
core   +1 more source

Down-Regulation of MutS Homolog 2 (MSH2) Expression by Curcumin Enhances Cytotoxicity Induced by Gemcitabine in Human Lung Adenocarcinoma Cells

, 2017
Gemcitabine (2′,2′-difluorodeoxycytidine) is a difluorinated analog of deoxycytidine. It is used clinically to treat patients with non-small-cell lung cancer (NSCLC).
J. Ko, Yi-Shuan Peng, Chia‐Hung Wu, Jyh-Cheng Chen, Hao-Yu Zheng, Yuan-Cheng Lin, Peng-Fang Ma, Wen-Ching Chen, Yun-Wei Lin   +8 more
semanticscholar   +1 more source

Molecular Basis of Mismatch Repair Protein Deficiency in Tumors from Lynch Suspected Cases with Negative Germline Test Results

Cancers, 2020
Some 10–50% of Lynch-suspected cases with abnormal immunohistochemical (IHC) staining remain without any identifiable germline mutation of DNA mismatch repair (MMR) genes.
A. Olkinuora, A. Gylling, H. Almusa, S. Eldfors, A. Lepistö, J. Mecklin, T. Nieminen, P. Peltomäki   +7 more
semanticscholar   +1 more source