Results 111 to 120 of about 333,256 (300)
, 2023 Source data from Phase Set Enrichment Analysis (PSEA) of oscillating genes from SKNAS N-MYC-ER OFF and ON.
Brian J. Altman (16819407) +14 more
core +1 more source
Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
, 2022 Additional file 2: Figure S2. RNF180 silencing contributed to the expression of C-myc through inhibiting its ubiquitination. A and B. Western blot was used to examine the protein level of C-myc in siNC and siRNF180 transfecting H292 and A549 with or ...
Yi Ding (172783) +4 more
core +1 more source
β‐Catenin/c‐Myc Axis Modulates Autophagy Response to Different Ammonia Concentrations
Advanced Biology, Volume 9, Issue 3, March 2025.Ammonia, detoxified by the liver into urea and glutamine, impacts autophagy differently at varying levels. Low ammonia activates autophagy via c‐Myc and β‐catenin, while high levels suppress it. Using Huh7 cells and Spf‐ash mice, c‐Myc's role in cytoprotective autophagy is revealed, offering insights into hyperammonemia and potential therapeutic ...
S. Sergio +11 more
wiley +1 more source
, 2011 Copyright information:Taken from "Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis"BMC Biology 2004;2():26-26.Published online 21 Dec 2004PMCID:PMC544575.Copyright ...
Sevasti Zervou (71022) +5 more
core +1 more source
Advanced Healthcare Materials, EarlyView.Pharmacokinetic engineering of clickable radioligands was achieved via albumin hitchhiking approach within a pretargeted radiotheranostics delivery platform. This approach reduced rapid renal elimination, expanded bioorthogonal capture window, boosted tumor uptake by ∼3.5‐fold, and improved the tumor‐to‐liver ratio by ∼6‐fold.
Xie He +9 more
wiley +1 more source
MYC-Targeting Inhibitors Generated from a Stereodiversified Bicyclic Peptide Library
Here, we present the second generation of our bicyclic peptide library (NTB), featuring a stereodiversified structure and a simplified construction strategy.
Desiree Aispuro (14019173) +13 more
core +2 more sources
Positive and negative regulation of Myc-mediated transcription
, 2008 The aim of this thesis has been focused to analyze the positive regulation of Myc-mediated transcription by P-TEFb elongation complex, and the negative control exerted by p14ARF onco-suppressor on Myc's transactivation functions.
Gargano, Barbara
core
Expression of cavin1-myc-BirA* as a tool to label caveolar proteins.
, 2018 A. Schematic representation of constructs used in this study. B. Expression of constructs used in this study, analysed by Western blotting with anti-myc antibodies. C.
I. Yeow (6160631) +3 more
core +1 more source
Fully 3D‐Printed Wave‐Wound Electromagnetic Motors
Advanced Materials Technologies, EarlyView.This work presents the first fully 3D‐printed wave‐wound electromagnetic motors, which are created using conductive nanoparticle inks, carbon‐filled nylon polymers, and surface mount components. These motors can achieve a stall torque of 7.62N·mmA−1$7.62 \nobreakspace N{\cdot }mm A^{-1}$ and efficiency of 28.2 %, which approaches the performance of ...
Joseph Schwalbe +4 more
wiley +1 more source