Results 91 to 100 of about 333,256 (300)
YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
, 2011 Copyright information:Taken from "Brief inactivation of c-Myc is not sufficient for sustained regression of c-Myc-induced tumours of pancreatic islets and skin epidermis"BMC Biology 2004;2():26-26.Published online 21 Dec 2004PMCID:PMC544575.Copyright ...
Sevasti Zervou (71022) +5 more
core +1 more source
Myc-mediated regulation of miRNA gene expression in Drosophila.
, 2023 (A) qRT-PCR showing myc transcript levels in GSG162>mycRNAi larvae in the presence of RU486 or vehicle. (B-D) qRT-PCR showing relative RNA levels of the indicated primary (B), precursor (D) or mature (C) miRNAs in GSG162>mycRNAi larvae in the absence or ...
Andrés Dekanty (235339) +3 more
core +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Association of overexpressed MYC gene with altered PHACTR3 and E2F4 genes contributes to non-small cell lung carcinoma pathogenesis [PDF]
Journal of Medical Biochemistry, 2019 Background: C-Myc is one of the major cellular oncogenes overexpressed in non-small cell lung carcinoma (NSCLC). Its deregulated expression is necessary but not sufficient for malignant transformation.
Dragoj Miodrag +6 more
doaj
Molecular & Cellular Oncology, 2019 Inhibiting the nuclear protein MYC involved in the majority of human cancers has long been considered an impossible mission and several technical challenges have discouraged the development of MYC inhibitory strategies.
Marie-Eve Beaulieu, Laura Soucek
doaj +1 more source
MYC-Luciferase Reporter Assay and q-PCR for MYC at the same timing with Luc-assay
, 2020 A luciferase reporter harboring -3.1 kb of the MYC promoter region was integrated into a pGL4 vector (Promega). A pT3.5-CAG-M1AP was generated with pENTR221-M1AP and pT3.5-CAG-DEST (Kurata M et al., PLoS One, 2018, PMID:30222773) using Gateway® LR ...
Akiko Yamamoto (89965) +1 more
core +1 more source
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Divergent DNA methylation patterns and gene expression in MYC and CDKN2B in canine transmissible venereal tumors [PDF]
Veterinary WorldBackground and Aim: Canine transmissible venereal tumor (CTVT), a unique transmissible cancer in dogs, affects the external genitalia and potentially spreads to other parts of the body. While somatic mutations in oncogenic and tumor-suppressing genes are
Soukkangna Keopaseuth +5 more
doaj +1 more source
Life or cell death: identifying c-Myc regulated genes in two distinct tissues [PDF]
The c-myc oncogene is over-expressed or deregulated in many human cancers. c-myc encodes a transcription factor, the oncoprotein c-Myc (Myc), which acts as a master regulator of genes involved in such diverse cellular processes as replication and growth,
Robson, Samuel Charles
core