Results 91 to 100 of about 77,428 (296)

Sarcoidosis revealed by recurrent dactylitis.

open access: yes
Arthritis &Rheumatology, Accepted Article.
Thomas Subervie   +7 more
wiley   +1 more source

Biological Conversion of Formate to Organic Compounds: Toward a Sustainable Formate Bioeconomy

open access: yesCarbon Energy, EarlyView.
Formate bioconversion plays a crucial role in achieving renewable resource utilization and sustainable development. To tap its full potential, it is important to identify the most appropriate microbial hosts for incorporating formate into building blocks, design the most promising metabolic pathways for transmitting formate into central carbon ...
Jinyi Qian   +3 more
wiley   +1 more source

Deuteration of Six‐Membered N‐Heteroarenes: Chemistry and Applications

open access: yesChemistry – A European Journal, EarlyView.
Deuterated six‐membered N‐Heteroarenes (6NHetAr) are finding utility in an increasing repertoire of applications. Our paper comprehensively reviews synthetic approaches that have been reported for the deuteration of 6NHetAr and their fused counterparts while providing an overview of established and emerging applications for these materials.
Liju Raju   +4 more
wiley   +1 more source

Pyrazinoic acid, the active form of the anti-tuberculosis drug pyrazinamide, and aromatic carboxylic acid analogs are protonophores

open access: yesFrontiers in Molecular Biosciences
Pyrazinoic acid is the active form of pyrazinamide, a first-line antibiotic used to treat Mycobacterium tuberculosis infections. However, the mechanism of action of pyrazinoic acid remains a subject of debate, and alternatives to pyrazinamide in cases of
Fabio L. Fontes   +8 more
doaj   +1 more source

Rational Design and Antimycobacterial Evaluation of Aryl Sulfonamide–Linked Isoniazid Hydrazones Against Mycobacterium Tuberculosis

open access: yesChemMedChem, EarlyView.
Molecular docking shows that ligands 8 (a–i) adopt a U‐shaped geometry in the InhA active site, enabling stronger interactions than 7 (j–r). Surprisingly, both sets display similar potency, indicating that factors like electronic effects or solvation also influence anti‐TB activity.
Mukanda Gedeon Kadima   +10 more
wiley   +1 more source

Synthesis of a Conformationally Fixed Bicyclomarin Derivative

open access: yesChemMedChem, EarlyView.
The synthesis of a new bicyclic derivative of cyclomarin is described. Cyclomarin is a marine cyclopeptide with excellent antituberculosis activity. The synthesis of the linear heptapeptide and the two macrolactamizations proceed smoothly. Based on an X‐ray structure of cyclomarin bound to ClpC1, a new conformationally fixed, bicyclic cyclomarin ...
Jennifer Greve   +2 more
wiley   +1 more source

Dynamics of Mpox infection in Nigeria: a systematic review and meta-analysis

open access: yesScientific Reports
The seasonal outbreaks of Mpox continue in most parts of West and Central Africa. In the past year, Nigeria had the highest number of reported cases.
Simeon Cadmus   +9 more
doaj   +1 more source

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