Results 61 to 70 of about 77,428 (296)
Disease Models & Mechanisms, 2020 Neonatal and infant immunity differs from that of adults in both the innate and adaptive arms, which are critical contributors to immune-mediated clearance of infection and memory responses elicited during vaccination.
Laylaa Ramos +2 more
doaj +1 more source
Advanced Science, EarlyView.Punicalagin, a pomegranate molecule, helps the body fight Mycobacterium abscessus. It preferentially boosts interstitial macrophages in the lung, stabilizing mitochondria and switching on the autophagy via SIRT1/FoxO3a, which lowers bacterial load without directly killing bacteria.
Kefan Bi +4 more
wiley +1 more source
Intelligent Theranostic Systems Enabled by Aggregation‐Induced Emission in Precision Medicine
Aggregate, EarlyView.Aggregation‐induced emission (AIE) luminogens are driving a new generation of intelligent theranostic systems that integrate high‐fidelity imaging and multifunctional therapy. This review highlights how AIEgens, through restriction of intramolecular motion (RIM), enable deep‐tissue NIR‐II imaging, ultrasensitive biosensing, CRISPR‐assisted gene ...
Qinqin Huang +7 more
wiley +1 more source
The DosR regulon of Mycobacterium avium and adaptation to hypoxia
Frontiers in Cellular and Infection MicrobiologyLike other tuberculous and nontuberculous mycobacterial pathogens of human lung such as Mycobacterium tuberculosis and M. abscessus, M. avium is likely exposed to a variety of stressors during infection, including hypoxic conditions inside activated ...
Juan M. Belardinelli +12 more
doaj +1 more source
Giardia's Epithelial Cell Interaction In Vitro: Mimicking Asymptomatic Infection?
Frontiers in Cellular and Infection Microbiology, 2017 The protozoan parasite Giardia duodenalis is responsible for more than 280 million cases of gastrointestinal complaints (“giardiasis”) every year, worldwide. Infections are acquired orally, mostly via uptake of cysts in contaminated drinking water. After
Martin R. Kraft +5 more
doaj +1 more source
Advanced NanoBiomed Research, EarlyView.Overview of the use of silica nanoparticles in vaccines against pathogens. Different kinds of vaccines against infectious diseases are currently using solid or mesoporous silica nanoparticles in their formulation. Silica microparticles and nanoparticles (SiNPs) have been studied as vehicles for vaccines.
Noe Juvenal Mendoza‐Ramírez +3 more
wiley +1 more source
Repurposing—a ray of hope in tackling extensively drug resistance in tuberculosis
International Journal of Infectious Diseases, 2015 Tuberculosis (TB) remains a serious concern more than two decades on from when the World Health Organization declared it a global health emergency. The alarming rise of antibiotic resistance in Mycobacterium tuberculosis, the etiological agent of TB, has
Arundhati Maitra +5 more
doaj +1 more source
Immunobiology, 2007 Exposure to mycobacteria was inevitable throughout mammalian evolution. Most mycobacteria are saprophytic environmental organisms that are enormously abundant in soil and untreated water and evoke immune responses in the residents of developing countries. A few species are pathogens.
Eckard Hamelmann +2 more
openaire +2 more sources
Noncoding RNAs in Host–Microbiota Interaction
Animal Research and One Health, EarlyView.The intricate interplay between gut microbiota and the host exerts a profound impact on host biological processes and disease development. This review highlights the pivotal role of noncoding RNAs (ncRNAs) in this interaction. Host ncRNAs regulate gene expression and microbiota composition, whereas microbial small RNAs (sRNAs) modulate host gene ...
Ziyi Zhao +7 more
wiley +1 more source
Frontiers in PharmacologyIntroductionThe standard treatment for tuberculosis is the isoniazid, rifampicin, pyrazinamide, and ethambutol (HRZE) regimen. Despite its efficacy, this regimen has limitations, including prolonged treatment duration and poor clinical outcomes in drug ...
Jason E. Cummings +13 more
doaj +1 more source