Results 91 to 100 of about 541,488 (343)

Immunological characteristics and functions of macrophages in Mycobacterium leprae infection

BMC Immunology
Objective Our research aimed to clarify the roles of M1 and M2 macrophages in leprosy, focusing on their polarization states, phagocytic capacities, and the survival of M. leprae within these macrophage subsets.
Xiaodong Zhang, Haiqin Jiang, Weijun Liu, Hongsheng Wang   +3 more
doaj   +1 more source

Effects of Age and Environment on Adaptive Immune Responses to Mycobacterium avium subsp. paratuberculosis (MAP) Vaccination in Dairy Goats in Relation to Paratuberculosis Control Strategies

Veterinary Sciences, 2019
Paratuberculosis infection is caused by Mycobacterium avium subsp. paratuberculosis (MAP). In the Netherlands, 75% herd level prevalence of caprine paratuberculosis has been estimated, and vaccination is the principal control strategy applied.
Ad Koets, Lars Ravesloot, Robin Ruuls, Annemieke Dinkla, Susanne Eisenberg, Karianne Lievaart-Peterson   +5 more
doaj   +1 more source

A Deep Representation Learning Method for Quantitative Immune Defense Function Evaluation and Its Clinical Applications

Advanced Science, EarlyView.
ImmuDef, a novel algorithm to quantitatively evaluate the anti‐infection immune defense function of an individual based on RNA‐seq data via a variational autoencoder (VAE) model. It is validated on 3200+ samples across four immune states with high accuracy. It can serve as a metric for disease severity and prognosis across pathogenic cohorts.
Zhen‐Lin Tan, Tao Luo, Yu Lin, Xiao‐Jun Wu, Wen‐Kang Shen, Jie Chen, Qian Lei, An‐Yuan Guo   +7 more
wiley   +1 more source

Mycobacterial Spindle Cell Pseudotumor Presenting as a Pancreatic Head Mass: A Case Report

Pathogens
Mycobacterial spindle cell pseudotumors (MSCPs) are rare lesions characterized by the proliferation of spindle-shaped histiocytes caused by mycobacterial infections.
Frank A Cusimano, Tara Herrera, Douglas Brust, Elizabeth Montgomery, Sunil Amin, Folusakin Ayoade   +5 more
doaj   +1 more source

Bactericidal Disruption of Magnesium Metallostasis in Mycobacterium tuberculosis Is Counteracted by Mutations in the Metal Ion Transporter CorA

mBio, 2019
A defining characteristic of treating tuberculosis is the need for prolonged administration of multiple drugs. This may be due in part to subpopulations of slowly replicating or nonreplicating Mycobacterium tuberculosis bacilli exhibiting phenotypic ...
Landys Lopez Quezada, Sandra Silve, Mark Kelinske, Amir Liba, Constantino Diaz Gonzalez, Martin Kotev, Laurent Goullieux, Stephanie Sans, Christine Roubert, Sophie Lagrange, Eric Bacqué, Cedric Couturier, Alain Pellet, Isabelle Blanc, Marlène Ferron, Fabrice Debu, Kelin Li, Jeffrey Aubé, Julia Roberts, David Little, Yan Ling, Jun Zhang, Ben Gold, Carl Nathan   +23 more
doaj   +1 more source

Hanks-Type Serine/Threonine Protein Kinases and Phosphatases in Bacteria: Roles in Signaling and Adaptation to Various Environments [PDF]

, 2018
Reversible phosphorylation is a key mechanism that regulates many cellular processes in prokaryotes and eukaryotes. In prokaryotes, signal transduction includes two-component signaling systems, which involve a membrane sensor histidine kinase and a ...
Janczarek, Monika, Karaś, Magdalena, Lipa, Paulina, Vinardell González, José María   +3 more
core   +1 more source

A Modular Biosensor Platform for the Detection of Plastic Monomers and the Engineering of Promiscuous Amidases Toward Challenging Substrates

Advanced Science, EarlyView.
A luciferase is used as biosensor for aldehydes, produced enzymatically from different monomeric building blocks of plastics like polyurethanes (PUs). The screening platform is used to monitor esterase, amidase, and urethanase activity and to guide the selection of enzyme variants with improved hydrolytic activities toward difficult to hydrolyze ...
Ina Somvilla, Hannah Meier, Florian Oehlschläger, Hannes Meinert, Lena Koch, Patrick Ihrle, Katharina M. Mehnert, Morten Flieger, Jonas Boß, Marco Seifert, Dominique Böttcher, Uwe T. Bornscheuer, Thomas Bayer   +12 more
wiley   +1 more source

Aspergillus fumigatus preexposure worsens pathology and improves control of Mycobacterium abscessus pulmonary infection in mice [PDF]

, 2018
Cystic fibrosis (CF) is an autosomal recessive disease caused by mutations in the CF transmembrane conductance regulator (CFTR) gene. Mutations in this chloride channel lead to mucus accumulation, subsequent recurrent pulmonary infections, and ...
Elsegeiny, Waleed, Gopal, Radha, Khader, Shabaana A, Kolls, Jay, McAleer, Jeremy P, Mehta, Shail, Monin, Leticia, Oury, Tim D   +7 more
core   +2 more sources

Deoxyribonucleic Acid Relatedness Among Selected Strains of Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium bovis BCG, Mycobacterium microti, and Mycobacterium africanum [PDF]

International Journal of Systematic Bacteriology, 1985
Deoxyribonucleic acids (DNAs) of selected strains of the Mycobacterium tuberculosis complex, including strains of M. tuberculosis, Mycobacterium bovis, M. bovis BCG, Mycobacterium microti, and Mycobacterium africanum, were isolated and analyzed spectrophotometrically.
openaire   +1 more source

Accelerating Primary Screening of USP8 Inhibitors from Drug Repurposing Databases with Tree‐Based Machine Learning

Advanced Intelligent Discovery, EarlyView.
This study introduces a tree‐based machine learning approach to accelerate USP8 inhibitor discovery. The best‐performing model identified 100 high‐confidence repurposable compounds, half already approved or in clinical trials, and uncovered novel scaffolds not previously studied. These findings offer a solid foundation for rapid experimental follow‐up,
Yik Kwong Ng, Sharon Ai Er Lam, Wei Chun Lim, Hannah Hui Min Toh, Shi Jun Ang   +4 more
wiley   +1 more source