Results 91 to 100 of about 648,089 (387)

Loss of NR2F6 Protects from Salmonella Typhimurium Infection

Advanced Science, EarlyView.
Loss of nuclear receptor NR2F6 reduces tissue‐resident macrophage populations. Nr2f6‐deficient mice are protected from weight loss and bacterial load during infection with Salmonella Typhimurium. Pro‐inflammatory cytokines and iron levels are altered in infected Nr2f6‐deficient mice.
Johannes Woelk, Christa Pfeifhofer‐Obermair, Julia Benz, Natascha Brigo, Milena Bamberger, Alexeja Kleiter, Martin Hermann, Guenter Weiss, Natascha Hermann‐Kleiter   +8 more
wiley   +1 more source

Enhanced heterogeneity of rpoB in Mycobacterium tuberculosis found at low pH.

, 2009
OBJECTIVES: The aim of this study was to gain an insight into the molecular mechanisms of the evolution of rifampicin resistance in response to controlled changes in the environment.
Allnutt, Jon, Arnold, Catherine, Bacon, Joanna, Bose, Alpana, Gillespie, Stephen H, Hatch, Kim A, Jenkins, Claire, McHugh, Timothy D, O'Sullivan, Denise M   +8 more
core   +1 more source

DNA repair systems and the pathogenesis of Mycobacterium tuberculosis: varying activities at different stages of infection [PDF]

, 2010
Mycobacteria, including most of all MTB (Mycobacterium tuberculosis), cause pathogenic infections in humans and, during the infectious process, are exposed to a range of environmental insults, including the host's immune response.
Adams, Afanasev, Alina E. Gorna, Aly, Arnold, Bacon, Banu, Bergval, Betts, Boshoff, Boshoff, Bostanabad, Burney, Capelli, Chan, Chan, Cheng, Cooper, Cubillos-Ruiz, Darwin, Darwin, Das, Davis, Dos Vultos, Dubnau, Durbach, Farnia, Fennelly, Filliol, Fleischmann, Flint, Fontan, Friedberg, Frischkorn, Fu, Fu, Gaynor, Gordhan, Graham, Grishko, Guthlein, Hampshire, Hazbon, Hughes, Jain, Jaroslaw Dziadek, Jiao, Kapur, Karakousis, Karakousis, Karunkaran, Katti, Kesavan, Kim, Ko, Ko, Korycka-Machala, Krokan, Kurthkoti, Kurthkoti, Lari, Lever, Loudon, MacMicking, Malshetty, Martinez, Mokrousov, Moller, Movahedzadeh, Mulder, Munoz-Elias, Muttucumaru, Nguyen, Niemann, Nikolayevskyy, Nouvel, O'sullivan, Olano, Peccia, Peccia, Pitcher, Rachman, Rachman, Rad, Ramaswamy, Richard P. Bowater, Riley, Saito, Sander, Sassetti, Sassetti, Saunders, Schnappinger, Schwab, Sherman, Sinha, Sinha, Smeulders, Springer, Srivastava, Stephanou, Talaat, Talaat, Tang, Tsai, Venkatesh, Vilcheze, Voskuil, Voskuil, Waddell, Wanner, Warner, Weikert, Wiid, Wiseman, World Health Organization, Zaczek, Zainuddin   +117 more
core   +1 more source

Advances in Single‐Cell Sequencing for Infectious Diseases: Progress and Perspectives

Advanced Science, EarlyView.
Single‐cell sequencing technologies uncover novel, unknown, and emergent features of many diseases. This review describes recent progress of single‐cell sequencing technologies and their applications in infectious diseases, summarizes the underlying commonalities of different infections and discusses future research directions, facilitating the ...
Mengyuan Lyu, Yang Liu, Jian Zhou, Hongli Lai, Hongxia Ruan, Dongsheng Wu, Shun Zhu, Xudong Zhou, Wananqi Ma, Yuchen Huang, Shuting Lei, Han Luo, Jie Chen, Binwu Ying   +13 more
wiley   +1 more source

Protection efficacy of Argentinian isolates of Mycobacterium avium subsp. paratuberculosis with different genotypes and virulence in a murine model [PDF]

, 2018
Paratuberculosis is a chronic disease caused by Mycobacterium avium subsp. paratuberculosis (Map). The disease causes economic losses and, therefore, it is imperative to follow proper control strategies, which should include an effective vaccine. Several
Alvarado Pinedo, María Fiorella, Colombatti Olivieri, María Alejandra, Delgado, Fernando Oscar, Gravisaco, Maria Jose Federica, Mon, Maria Laura, Moyano, Roberto Damian, Romano, Maria Isabel, Santangelo, María de la Paz, Travería, Gabriel Eduardo   +8 more
core   +1 more source

Rifampicin and clarithromycin (extended release) versus rifampicin and streptomycin for limited Buruli ulcer lesions: a randomised, open-label, non-inferiority phase 3 trial. [PDF]

, 2020
BACKGROUND: Buruli ulcer is a neglected tropical disease caused by Mycobacterium ulcerans infection that damages the skin and subcutis. It is most prevalent in western and central Africa and Australia.
Abass, KM, Agossadou, D, Ampadu, EO, Asiedu, KB, Chauty, A, Egondi, TW, Frimpong, M, Ganlonon, L, Gateau, T, Grosset, J, Lehman, L, Macdonald, JM, Marion, E, Ochieng Otieno, M, Ohene, S-A, Omollo, R, Paintsil, A, Phillips, RO, Robert, J, Saizonou, R, Sarfo, FS, Sarpong, G, Sarpong, NF, Saunderson, P, Stienstra, Y, study team, Thompson, W, Tiendrebeogo, A, Treadwell, T, van der Werf, TS, Wansbrough-Jones, M, Wilson, T   +31 more
core   +3 more sources

Comparative pathogenesis of Mycobacterium marinum and Mycobacterium tuberculosis [PDF]

Cellular Microbiology, 2008
A thorough understanding of Mycobacterium tuberculosis pathogenesis in humans has been elusive in part because of imperfect surrogate laboratory hosts, each with its own idiosyncrasies. Mycobacterium marinum is the closest genetic relative of the M. tuberculosis complex and is a natural pathogen of ectotherms.
Lalita Ramakrishnan, David M. Tobin
openaire   +3 more sources

Integrated Transcriptome and Metabolomics Analyses Show MYC as a Potential Therapeutic Target for Behçet's Uveitis

Advanced Science, EarlyView.
Integrated single‐cell transcriptomic and metabolomic analyses reveal that MYC‐driven glycolysis activates the PI3K‐AKT‐FOXO1 pathway, disrupting Th17/Treg balance and promoting uveitis. MYC inhibition restores immune homeostasis and alleviates disease symptoms.
He Li, Lei Zhu, Zhaohuai Li, Yihan Zhang, Genxian Zhang, Xuening Peng, Dongting Wu, Qi Jiang, Rong Wang, Renbing Jia, Song Guo Zheng, Wenru Su   +11 more
wiley   +1 more source

Clinically Relevant Mutations of Mycobacterial GatCAB Inform Regulation of Translational Fidelity

mBio, 2021
Most bacteria employ a two-step indirect tRNA aminoacylation pathway for the synthesis of aminoacylated tRNAGln and tRNAAsn. The heterotrimeric enzyme GatCAB performs a critical amidotransferase reaction in the second step of this pathway.
Yang-Yang Li, Rong-Jun Cai, Jia-Ying Yang, Tamara L. Hendrickson, Ye Xiang, Babak Javid   +5 more
doaj   +1 more source

Tuberculosis in Dr Granville's mummy: a molecular re-examination of the earliest known Egyptian mummy to be scientifically examined and given a medical diagnosis [PDF]

, 2010
‘Dr Granville's mummy’ was described to the Royal Society of London in 1825 and was the first ancient Egyptian mummy to be subjected to a scientific autopsy.
Abu Al-Soud W., Boom R., David E. Minnikin, Forbes B. A., Granville A. B., Gurdyal S. Besra, Harer W. B., Helen D. Donoghue, Hellyer T. J., John H. Taylor, Mark Spigelman, Minnikin D. E., Oona Y.-C. Lee, Tapp E., Taylor G. M., Taylor G. M.   +15 more
core   +2 more sources