Results 41 to 50 of about 530,034 (290)

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Phosphomimetic mutations near active sites of proteins in Thermus thermophilus suggest a widespread regulatory mechanism

FEBS Open Bio, EarlyView.
In Thermus thermophilus, more than half of the phosphorylation sites identified by proteomic analysis are located near the active site. All phosphomimetic mutants of phosphosites of six enzymes belonging to different families showed severely reduced activity compared with the wild‐type, particularly in the turnover number.
Anzu Nishiwaki, Hiroki Okanishi, Yoshikatsu Kanai, Ryoji Masui   +3 more
wiley   +1 more source

Assessing the accuracy of the updated Fujifilm SILVAMP TB LAM II assay between lot numbers

IJTLD Open
BACKGROUND: The Fujifilm SILVAMP TB LAM (FujiLAM) assay, a point-of-care test detecting urine-based lipoarabinomannans, has demonstrated notable diagnostic accuracy for TB. However, FujiLAM exhibits lot-to-lot variability, limiting its clinical use.
K. Chikamatsu, Y. Shimomura, A. Osugi, S. Mitarai   +3 more
doaj   +1 more source

Granuloma lepróide canino: Relato de caso

Pubvet, 2021
O Granuloma Lepróide Canino é uma doença causada por uma micobactéria que provoca lesões nodulares, podendo afetar a derme e/ou tecido subcutâneo, normalmente sendo firmes à palpação, indolores, podendo ser alopécicas e ulceradas.
Larissa Schimanski, Meire Christina Seki, Fatima Abou Ghaouche de Moraes, Yohhane Tracy Hofmann Nascimento, Karoline Vintureli Felício, Adriano de Oliveira Torres Carrasco, Carla Fredrichsen Moya   +6 more
doaj   +1 more source

A Multinational Analysis of Mutations and Heterogeneity in PZase, RpsA, and PanD Associated with Pyrazinamide Resistance in M/XDR Mycobacterium tuberculosis. [PDF]

, 2017
Pyrazinamide (PZA) is an important first-line drug in all existing and new tuberculosis (TB) treatment regimens. PZA-resistance in M. tuberculosis is increasing, especially among M/XDR cases.
Catanzaro, A, Catanzaro, D, Fink, L, Jackson, RL, Pettigrove, M, Ramirez-Busby, SM, Rodwell, TC, Valafar, F   +7 more
core   +1 more source

Exploring clues for wide variations in COVID-19 fatality rates among countries

MGM Journal of Medical Sciences, 2022
COVID-19 flu has been the worst pandemic on earth in more than a century and has thus far claimed more than six million lives worldwide. As of 19th March 2022, there were 57 major countries where one million or more COVID-19cases were registered, and the
Prasanta Kumar Ghosh
doaj   +1 more source

Four decades of transmission of a multidrug-resistant Mycobacterium tuberculosis outbreak strain [PDF]

, 2015
The rise of drug-resistant strains is a major challenge to containing the tuberculosis (TB) pandemic. Yet, little is known about the extent of resistance in early years of chemotherapy and when transmission of resistant strains on a larger scale became a
Balloux, Francois, Eldholm, Vegard, Lopez, Beatriz, Monteserin, Johana, Rieux, Adrien, Ritacco, Gloria Viviana, Sobkowiak, Benjamin   +6 more
core   +4 more sources

Cholesterol in mRNA‐Lipid Nanoparticles can be Replaced with the Synthetic Mycobacterial Monomycoloyl Glycerol Analogue MMG‐1

Advanced Functional Materials, EarlyView.
This study demonstrates that cholesterol in messenger RNA‐lipid nanoparticles (mRNA‐LNPs) can be completely replaced with an immunopotentiating lipid, i.e., a synthetic analogue of the C‐type lectin receptor agonist monomycoloyl glycerol (MMG‐1), without compromising physicochemical properties, in vivo transfection efficiency, and immunogenicity of the
Abhijeet G. Lokras, Saahil S. Baghel, Rune F. Jensen, Aneesh Thakur, Henrik Franzyk, Oskar Thofte, Marco Herrera‐Barrera, Madeleine Landry, Melike Ongun, Ahmad Tami, Marlene P. Thanthrige, Eva Callens, Corinne Beinat, Thomas Rades, Søren R. Paludan, Kristian Riesbeck, Ida Rosenkrands, Dennis Christensen, Gabriel K. Pedersen, Camilla Foged   +19 more
wiley   +1 more source

Mycobacterium tuberculosis is less likely to acquire pathogenic mutations during latent infection than during active disease

Microbiology Spectrum
Most people infected with Mycobacterium tuberculosis (Mtb) are believed to be in a state of latent tuberculosis (TB) infection (LTBI). Although LTBI is asymptomatic and not infectious, there is a risk of developing active disease even decades after ...
Asami Osugi, Aki Tamaru, Takashi Yoshiyama, Tomotada Iwamoto, Satoshi Mitarai, Yoshiro Murase   +5 more
doaj   +1 more source

DRAM1 Promotes Lysosomal Delivery of Mycobacterium marinum in Macrophages

Cells, 2023
Damage-Regulated Autophagy Modulator 1 (DRAM1) is an infection-inducible membrane protein, whose function in the immune response is incompletely understood.
Adrianna Banducci-Karp, Jiajun Xie, Sem A. G. Engels, Christos Sarantaris, Patrick van Hage, Monica Varela, Annemarie H. Meijer, Michiel van der Vaart   +7 more
doaj   +1 more source