Results 121 to 130 of about 105,796 (273)

One‐Stone‐Three‐Birds Biomimetic Oral Targeting Delivery Strategy for On‐Demand Controlled Drug Release and Intervertebral Disc Degeneration Therapy

Exploration, EarlyView.
ABSTRACT Intervertebral disc degeneration (IDD) is a multifactorial condition characterized by excessive inflammation, immune dysfunction, and metabolic disorders. Current therapeutic strategies primarily rely on local injection, a traumatic approach associated with risks of tissue damage and infection.
Yifan Ding, Yixin Cai, Weizhen Pan, Na Hu, Yunyun Wang, Huan Wang, Huang Fang, Songwei Tan, Zhiping Zhang   +8 more
wiley   +1 more source

Effect of medicinal and food homologous plants polysaccharides on animal nutrition and health: A review

Food Biomacromolecules, EarlyView.
Abstract As one of the most important components of foods, animal meat provides a lot of protein, fat, and energy for humans. However, nutrition and health of animals directly affect the healthiness of human, especially antibiotic residues in animals induced by abuse of antibiotics.
Zichao Wang, Yi Zheng, Changxing Liu, Danye Zhu, Yingjie Feng, Hongtao Zhang, Qi Wang, Qinggong Chen, Xueyi Qiao   +8 more
wiley   +1 more source

Liver Regeneration after Partial Hepatectomy Is Not Impaired in Mice with Double Deficiency of Myd88 and IFNAR Genes

Gastroenterology Research and Practice, 2011
Liver regeneration is known to occur in mice lacking one or more Toll-like receptors (TLRs) or the adaptor protein MyD88. Though MyD88 is required for signaling by many TLRs, others signal via MyD88-independent pathways, leading to the induction of type ...
Javier Vaquero, Kimberly J. Riehle, Nelson Fausto, Jean S. Campbell   +3 more
doaj   +1 more source

Suppression of MyD88-dependent signaling alleviates neuropathic pain induced by peripheral nerve injury in the rat

Journal of Neuroinflammation, 2017
Background MyD88 is the adaptor protein of MyD88-dependent signaling pathway of TLRs and IL-1 receptor and regulates innate immune response. However, it was not clear whether and how MyD88 and related signaling pathways in the dorsal root ganglion (DRG ...
Fan Liu, Zhiyao Wang, Yue Qiu, Min Wei, Chunyan Li, Yikuan Xie, Le Shen, Yuguang Huang, Chao Ma   +8 more
doaj   +1 more source

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

MyD88 Regulates the Expression of SMAD4 and the Iron Regulatory Hormone Hepcidin

Frontiers in Cell and Developmental Biology, 2018
The myeloid differentiation primary response gene 88 (MyD88) is an adaptive protein that is essential for the induction of inflammatory cytokines through almost all the Toll-like receptors (TLRs).
Macha Samba-Mondonga, Macha Samba-Mondonga, Annie Calvé, Frédérick A. Mallette, Frédérick A. Mallette, Manuela M. Santos, Manuela M. Santos   +6 more
doaj   +1 more source

A MyD88 meddles with survival [PDF]

The Journal of Experimental Medicine, 2007
In the MyD88 family of cytosolic adaptor proteins, the newest member is the group's black sheep, according to Kim et al. (page 2063). Whereas most MyD88 proteins turn on antipathogen responses within myeloid cells, the rebel, MyD88-5, instigates cell death within neurons.
openaire   +1 more source

Respiratory Syncytial Virus Under the Lens of Structure: From Prefusion Stabilization to Next‐Generation Immunotherapies

iNew Medicine, EarlyView.
This illustration integrates key concepts covered in the review, including high‐risk populations, viral structure, host entry factors, the replication cycle, and licensed antibody‐based prevention strategies. ABSTRACT Respiratory syncytial virus (RSV) is a negative‐sense RNA virus belonging to the genus Orthopneumovirus within the family Pneumoviridae.
Zekai Cheng, Qianqian Wang, Jiachen Zhang, Sandra Chiu   +3 more
wiley   +1 more source

Prognostic values of myeloid differentiation factor 88 (MYD88) and transducin (β)-like receptor 1 (TBLR1) expression in tissues of diffuse large B-cell non-Hodgkin lymphoma patients – an immunohistochemical study

Contemporary Oncology, 2022
Asmaa Mohamed, Mariem Elfeky, Shereen Elshorbagy, Nabila Hefzi, Tamer Oraby, Waleed Abdelhady, Mahmoud Eldein, Ahmed Embaby, Ehab Oraby   +8 more
doaj   +1 more source

MyD88 polymerization and association to cellular membranes in a yeast heterologous model

Cellular and Molecular Life Sciences
MyD88 is a key mediator of Toll-like receptor (TLR) signaling, orchestrating the innate immune response upon stimulation by pathogen-associated molecular patterns (PAMPs).
Elba del Val, Alejandro Fernández-Vega, María Molina, Víctor J. Cid   +3 more
doaj   +1 more source