Results 131 to 140 of about 123,738 (330)

Nanomaterial‐based immune therapeutic strategies in neurodegenerative diseases

BMEMat, EarlyView.
This review highlights the immunomodulatory potential of nanomaterials (NMs) in treating neurodegenerative diseases (NDs). It focuses on their roles in regulating innate and adaptive immune responses to maintain immune homeostasis. By providing insights into these mechanisms, the review lays the groundwork for innovative NMs therapeutic strategies to ...
Xinru Zhou, Jia Liu, Shulin Lai, Suhan Yin, Bingmin Luo, Longquan Shao, Yiyuan Kang   +6 more
wiley   +1 more source

Protein Phosphatase 2A Catalytic Subunit α Plays a MyD88-Dependent, Central Role in the Gene-Specific Regulation of Endotoxin Tolerance

Cell Reports, 2013
MyD88, the intracellular adaptor of most TLRs, mediates either proinflammatory or immunosuppressive signaling that contributes to chronic inflammation-associated diseases.
Ling Xie, Cui Liu, Li Wang, Harsha P. Gunawardena, Yanbao Yu, Ruyun Du, Debra J. Taxman, Penggao Dai, Zhen Yan, Jing Yu, Stephen P. Holly, Leslie V. Parise, Yisong Y. Wan, Jenny P. Ting, Xian Chen   +14 more
doaj   +1 more source

MYD88 mutations identify a molecular subgroup of diffuse large B-cell lymphoma with an unfavorable prognosis

Haematologica, 2019
The 2016 World Health Organization classification defines diffuse large B-cell lymphoma (DLBCL) subtypes based on Epstein-Barr virus (EBV) infection and oncogenic rearrangements of MYC/BCL2/BCL6 as drivers of lymphomagenesis.
J. Vermaat, S. Somers, L. D. de Wreede, W. Kraan, R. D. de Groen, A. Schrader, E. D. Kerver, C. Scheepstra, H. Berenschot, W. Deenik, J. Wegman, R. Broers, J. D. de Boer, M. Nijland, T. van Wezel, H. Veelken, M. Spaargaren, A. Cleven, M. Kersten, S. Pals   +19 more
semanticscholar   +1 more source

Compartment-Specific and Sequential Role of MyD88 and CARD9 in Chemokine Induction and Innate Defense during Respiratory Fungal Infection [PDF]

, 2015
Aspergillus fumigatus forms ubiquitous airborne conidia that humans inhale on a daily basis. Although respiratory fungal infection activates the adaptor proteins CARD9 and MyD88 via C-type lectin, Toll-like, and interleukin-1 family receptor signals ...
Cramer, RA, Heung, LJ, Hohl, TM, Jhingran, A, Junecko, BAF, Kasahara, S, Kazmierczak, BI, Knoblaugh, SE, Kumasaka, DK, Lin, X, Reinhart, TA, Shepardson, KM   +11 more
core   +1 more source

Eudragit®‐engineered pH‐responsive probiotic microspheres with enhanced gastrointestinal resistance and prolonged storage stability for inflammatory bowel disease therapy

BMEMat, EarlyView.
This study reports the development of AMS@Eud core‐shell microspheres, combining calcium alginate and pH‐responsive Eudragit® L100, which exhibit exceptional gastrointestinal resistance and long‐term storage stability (only 5.28%–9.09% viability loss over 35 days at 4–25°C), and effectively alleviate inflammatory bowel disease via gut microbiota ...
Ming Teng, Xiaomin Luo, Peng Zhang, Chen Yang, Yuniel Ma, Xinhua Liu   +5 more
wiley   +1 more source

Cell-type specific MyD88 signaling is required for intestinal tumor initiation and progression to malignancy

OncoImmunology, 2018
The signal adapter MyD88, an essential component of Toll-like receptor (TLR) signaling, is important for gut-microbiome interactions. However, its contribution to cancer and its cell-type specific functions are controversially discussed.
Anne Holtorf, Anja Conrad, Bernhard Holzmann, Klaus-Peter Janssen   +3 more
doaj   +1 more source

Circular RNA CEP128 promotes bladder cancer progression by regulating Mir‐145‐5p/Myd88 via MAPK signaling pathway

International Journal of Cancer, 2019
The present experiment was designed for exploring the regulatory mechanism of circ‐CEP128/miR‐145‐5p/MYD88 axis in bladder cancer. MiRNAs and circRNAs expression data were derived from Gene Expression Omnibus database with bladder tumor tissues and ...
Ming Sun, Wenyan Zhao, Zhaofu Chen, Ming Li, Shuqiang Li, Bin Wu, Renge Bu   +6 more
semanticscholar   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

MyD88 mediates colorectal cancer cell proliferation, migration and invasion via NF-κB/AP-1 signaling pathway

International Journal of Molecular Medicine, 2019
The role of myeloid differentiation factor 88 (MyD88) in malignant tumors is largely unknown. Therefore, in this study, we aimed to examine the function and underlying mechanism of MyD88 in colorectal carcinoma in vitro using SW480 and HCT116 cell lines ...
G. Zhu, Zhibin Cheng, Yongjian Huang, Wei Zheng, Shugang Yang, Chunlin Lin, Jianxin Ye   +6 more
semanticscholar   +1 more source

HSP110 and MYD88: blame the chaperone [PDF]

Blood, 2018
In this issue of Blood, Boudesco et al show that heat shock protein HSP110 (HSPH1) stabilizes wild-type and mutant MYD88, facilitating NF-κB activation in diffuse large B-cell lymphoma (DLBCL ...
openaire   +2 more sources