Results 61 to 70 of about 123,738 (330)

Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice. [PDF]

, 2013
BackgroundSpinal Toll-like receptors (TLRs) and signaling intermediaries have been implicated in persistent pain states. We examined the roles of two major TLR signaling pathways and selected TLRs in a mononeuropathic allodynia.MethodsL5 spinal nerve ...
A Ledeboer, AI de la Llave-Rincon, AL Oaklander, AS Jaggi, BJ Marsh, C Erridge, C Fernandez-de-las-Penas, C Fernandez-de-las-Penas, CA Christianson, CC Bowman, CF Kim, CI Svensson, CR Stewart, CS Jack, D Kim, D Kim, F Kozin, F Marchand, FY Tanga, H Cao, H Hacker, H Hashizume, H Tsujino, H Yanai, I Bettoni, J Mika, J Zhang, JA DeLeo, JA Stokes, JA Stokes, Jennifer A Stokes, JL Hylden, JM Chung, Jonathan Cheung, K Hoebe, K Honda, K Hoshino, K Kariko, KA Cavassani, Kelly Eddinger, KH Konopka, L Cao, L Nicotra, L Znaor, LA O’Neill, LA Panagio, LH Guo, M Bsibsi, M Calvo, M Chacur, M Hossaini, M Koltzenburg, M Yamamoto, Maripat Corr, MR Hutchinson, MR Hutchinson, NE Saade, O Adachi, O Saito, O Takeuchi, P Hu, P Hu, Q Xu, Q Zhang, R Wang, RE Sorge, RG Chen, RG Zanon, S Akira, S Akira, S Hosmane, S Lehnardt, S Nadeau, S Pu, S Rivest, S Sakaguchi, SR Chaplan, SW Mitchell, T Kawai, T King, T Liu, T Shichita, T Tanaka, Tony L Yaksh, TW Vanderah, V Huge, V Raghavendra, V Raghavendra, XY Hua, Y Ohmichi, YR Wen   +90 more
core   +1 more source

Two Human MYD88 Variants, S34Y and R98C, Interfere with MyD88-IRAK4-Myddosome Assembly [PDF]

Journal of Biological Chemistry, 2011
Innate immune receptors detect microbial pathogens and subsequently activate adaptive immune responses to combat pathogen invasion. MyD88 is a key adaptor molecule in both Toll-like receptor (TLR) and IL-1 receptor superfamily signaling pathways. This is illustrated by the fact that human individuals carrying rare, naturally occurring MYD88 point ...
George, J, Motshwene, P, Wang, H, Kubarenko, A, Rautanen, A, Mills, T, Hill, A, Gay, N, Weber, A   +8 more
openaire   +3 more sources

The oncogenic human B-cell lymphoma MYD88 L265P mutation genocopies activation by phosphorylation at the Toll/interleukin-1 receptor (TIR) domain

Blood Cancer Journal, 2023
MYD88 is the key signaling adaptor-protein for Toll-like and interleukin-1 receptors. A somatic L265P mutation within the Toll/interleukin-1 receptor (TIR) domain of MYD88 is found in 90% of Waldenström macroglobulinemia cases and in a significant subset
Marthe Minderman, Hildo Lantermans, Carmen van der Zwaan, Arie J. Hoogendijk, Maartje van den Biggelaar, Marie José Kersten, Marcel Spaargaren, Steven T. Pals   +7 more
doaj   +1 more source

Hepatocyte-specific regulation of autophagy and inflammasome activation via MyD88 during lethal Ehrlichia infection

Frontiers in Immunology, 2023
Hepatocytes play a crucial role in host response to infection. Ehrlichia is an obligate intracellular bacterium that causes potentially life-threatening human monocytic ehrlichiosis (HME) characterized by an initial liver injury followed by sepsis and ...
Omid Teymournejad, Aditya Kumar Sharma, Mohammed Abdelwahed, Mohammed Abdelwahed, Muhamuda Kader, Ibrahim Ahmed, Hoda Elkafas, Nahed Ismail   +7 more
doaj   +1 more source

Inhibitory Effects of the Lactobacillus rhamnosus GG Effector Protein HM0539 on Inflammatory Response Through the TLR4/MyD88/NF-кB Axis

Frontiers in Immunology, 2020
Inflammatory bowel disease (IBD) is a chronic and relapsing intestinal inflammatory condition with no effective treatment. Probiotics have gained wide attention because of their outstanding advantages in intestinal health issues.
Yubin Li, Shaojie Yang, J. Lun, Jie Gao, Xuefeng Gao, Z. Gong, Y. Wan, Xiaolong He, H. Cao   +8 more
semanticscholar   +1 more source

TRAM is involved in IL-18 signaling and functions as a sorting adaptor for MyD88. [PDF]

PLoS ONE, 2012
MyD88, a Toll/interleukin-1 receptor homology (TIR) domain-containing adaptor protein, mediates signals from the Toll-like receptors (TLR) or IL-1/IL-18 receptors to downstream kinases. In MyD88-dependent TLR4 signaling, the function of MyD88 is enhanced
Hidenori Ohnishi, Hidehito Tochio, Zenichiro Kato, Norio Kawamoto, Takeshi Kimura, Kazuo Kubota, Takahiro Yamamoto, Tatsuyoshi Funasaka, Hiroshi Nakano, Richard W Wong, Masahiro Shirakawa, Naomi Kondo   +11 more
doaj   +1 more source

Possible Involvement of MyD88 in Regulating Stress Response in Mice

Frontiers in Neuroscience, 2021
Myeloid differentiation primary response 88 (MyD88) is an adapter protein of the toll-like receptor (TLR) family that regulates innate immune function. Here, we identified a novel role of MyD88 in regulating stress response.
Toru Hosoi, Yosuke Yamawaki, Yosuke Yamawaki, Hitomi Kimura, Shoko Honda, Koichiro Ozawa   +5 more
doaj   +1 more source

The minor house dust mite allergen Der p 13 is a fatty acid binding protein and an activator of a TLR2-mediated innate immune response [PDF]

, 2016
Background: The house dust mite (HDM) allergen Der p 13 could be a lipid-binding protein able to activate key innate signaling pathways in the initiation of the allergic response.
Banerjee, Batard, Bergenhenegouwen, Bublin, Calderón, Chan, Chiou, Eriksson, Eriksson, Gillilan, Gras, Guillot, Herre, Hunter, Jacquet, Jacquet, Jacquet, Jenkins, Jeong, Jimenez, Kennedy, Kennedy, Kidon, Kitajima, Lambrecht, Li, Liang, Liu, Mei, Mueller, Mueller, Osterlund, Puerta, Pulsawat, Ryu, Soh, Storch, Taylor, Thomas, Tovey, Trompette, Tully, Wiegand, Young, Zähringer   +44 more
core   +1 more source

MyD88-Dependent and MyD88-Independent Pathways in Synergy, Priming, and Tolerance between TLR Agonists [PDF]

The Journal of Immunology, 2007
Abstract TLRs sense components of microorganisms and are critical host mediators of inflammation during infection. Different TLR agonists can profoundly alter inflammatory effects of one another, and studies suggest that the sequence of exposure to TLR agonists may importantly impact on responses during infection.
Aranya, Bagchi, Elizabeth A, Herrup, H Shaw, Warren, James, Trigilio, Hae-Sook, Shin, Catherine, Valentine, Judith, Hellman   +6 more
openaire   +2 more sources

In vitro study of momordin Ic in improving atopic dermatitis by regulating claudin-1/MyD88 and targeting NLRP3 [PDF]

Acta Poloniae Pharmaceutica
Atopic dermatitis (AD) is a non-infectious inflammatory skin disease characterized by persistent itching of the skin, and it has become a global health problem with increasing incidence and complex pathogenesis.
Ying Guo, Litao Wang, Jing Zhang, Tingting Jing, Lefan Fu, Guoying Miao   +5 more
doaj   +1 more source