Results 131 to 140 of about 8,110,219 (215)
ABSTRACT Objectives Retrograde trans‐synaptic degeneration (rTSD) from posterior visual pathway lesions in multiple sclerosis (MS) is characterized by hemi‐macular ganglion cell‐inner plexiform layer (GCIPL) thinning and contralateral visual field loss.
Abdul Jaber Tayem +17 more
wiley +1 more source
Editorial: Myelin-Mediated Inhibition of Axonal Regeneration: Past, Present, and Future
Wilfredo Mellado, Sari Hannila
doaj +1 more source
Objective Epstein–Barr virus (EBV) has been implicated in the pathogenesis of multiple sclerosis (MS). Elevated immunoglobulin G (IgG) titers against EBV nuclear antigen 1 (EBNA1) represent the most consistent serological marker of MS risk, with levels remaining persistently elevated following disease onset.
Malina Behrens +9 more
wiley +1 more source
A Phase Ib Case Series Using Bortezomib With Chemotherapy in Atypical Teratoid/Rhabdoid Tumors
ABSTRACT Background Atypical teratoid/rhabdoid tumors (ATRTs) are aggressive pediatric brain tumors that are sensitive to proteasome inhibitors in preclinical models. We evaluated the feasibility of combining the proteasome inhibitor, bortezomib, with chemotherapy.
Wan‐Ling Ho +38 more
wiley +1 more source
Myelin oligodendrocyte glycoprotein associated disease
Nikhat Iqbal Tamboli +3 more
doaj +1 more source
ABSTRACT Post‐traumatic hiccups are an uncommon but distressing complication of traumatic brain injury (TBI), often resistant to conventional pharmacological agents, and the underlying mechanism may involve central neurological disruption of inhibitory pathways rather than gastrointestinal or metabolic aetiologies. We report a male patient in his early
Rostom Karajeh +4 more
wiley +1 more source
ABSTRACT Adalimumab is a monoclonal antibody that targets TNF‐α and is effective in treating several autoimmune disorders, including non‐infectious uveitis; however, it has been associated with demyelinating lesions. This study presents two cases of CNS demyelination in patients who consumed adalimumab. First, an 18‐year‐old man presented with subacute
Marzie Abutorabi‐zarchi +2 more
wiley +1 more source
Progressive BBB/BSCB dysfunction is increasingly recognized as both a pathological feature and a therapeutic barrier in ALS. Novel delivery technologies and barrier‐restoration strategies may enhance CNS drug exposure, improve the efficacy of disease‐modifying therapies, and advance ALS treatment. ABSTRACT Background Amyotrophic lateral sclerosis (ALS)
Nitesh Sanghai +9 more
wiley +1 more source

