Results 141 to 150 of about 8,110,219 (215)

Whole‐Brain Monosynaptic Inputs and Outputs of Corticotropin‐Releasing Hormone Neurons of the Paraventricular Nucleus of the Hypothalamus in Male Mice

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Using rabies‐based monosynaptic retrograde tracing and AAV anterograde labeling, this study maps the brain‐wide inputs and outputs of PVN CRH neurons, identifying them as a key hub coordinating stress, autonomic, and behavioral responses. ABSTRACT Objective The paraventricular nucleus of the hypothalamus (PVN) is a central hub integrating ...
Ziteng Yue, Danyang Zhao, Xinxin Chen, Yousheng Zhang, Heng Zhang, Yinchang Wang, Yuhang Liu, Yuxin Yang, Can Geng, Yimeng Song, Xiaoyi Wang, Sheng Wang   +11 more
wiley   +1 more source

Frequency and Characteristics of Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease Accompanied by Fever: A Single‐Center Retrospective Study

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Diagnostic pitfall in fever with CNS involvement: MOGAD. Fever accompanied by neurological symptoms was initially suspected as central nervous system infection. However, negative pathogen tests and failed anti‐infective therapy, followed by positive MOG‐IgG, led to a revised diagnosis of MOGAD. The patient responded favorably to corticosteroids or IVIG.
Ai Guo, Fu‐Dong Shi, Kaibin Shi
wiley   +1 more source

Myelin Oligodendrocyte Glycoprotein Antibody Associated Disease (MOGAD) Revisited

The purpose of this presentation is to review the varied clinical manifestations of MOGAD for the neurology and neuro-ophthalmology providers.Associations of paediatric demyelinating and encephalitic syndromes with myelin oligodendrocyte glycoprotein ...
Zahir Sheikh; Michael Gilhooley
core  

Emodin Suppresses the RAGE/ROCK1 Pathway to Modulate the Oligodendrocyte Lineage and Ameliorate Demyelination in Vascular Dementia Rats

CNS Neuroscience &Therapeutics, Volume 32, Issue 9, September 2026.
Emodin improves white matter remyelination and alleviates cognitive deficits through suppression of the RAGE/ROCK1 signaling pathway in VD rats. Mechanistically, it modulates the OL lineage by reducing the elevated proliferative response of OPCs while promoting their maturation and remyelination.
Xueqing Wang, Xiumei Dong, Cunbao He, Junjie Zhang, Wenming Ban, Guoqi Zhu, Jingji Wang, Yilan Zhen   +7 more
wiley   +1 more source

Exploring Healthcare Continuity in Pediatric‐Onset Multiple Sclerosis in the United States

Annals of the Child Neurology Society, Volume 4, Issue 3, Page 177-187, September 2026.
ABSTRACT Objective Little is known about shifting from pediatric to adult‐focused multiple sclerosis (MS) care. This study aims to explore transition of care and follow‐up in the US pediatric‐onset MS (POMS) population. Methods Surveys were distributed to 10 sites in the US Network of Pediatric MS Centers (US NPMSC) about transition‐of‐care practices ...
Aaron W. Abrams, Michael Waltz, Jonathan Race, T. Charles Casper, Claudia Gambrah‐Lyles, Kimberly O'Neill, Akash Virupakshaiah, Kristen S. Fisher, Melissa A. Wright, Kelsey E. Poisson, Eva‐Chava M. Bernfeld, Gregory Aaen, Leslie A. Benson, Tanuja Chitnis, Carla Francisco, Grace Y. Gombolay, Mark P. Gorman, Jennifer S. Graves, Lauren Krupp, Timothy E. Lotze, Soe Mar, Jayne Ness, Mary Rensel, Moses Rodriguez, Teri Schreiner, Nikita Shukla, Jan‐Mendelt Tillema, Bianca Weinstock‐Guttman, Yolanda Wheeler, Emmanuelle Waubant, John Rose, US Network of Pediatric MS Centers   +31 more
wiley   +1 more source

Sickle Cell Disease and Kidney Injury: Circulating Uromodulin Allows Early Tissue Specific Diagnosis and Monitoring of Treatment

American Journal of Hematology, Volume 101, Issue 9, Page 2430-2434, September 2026.
Ferras Alashkar, Robert Hable, Denise Zwanziger, Friederike Poppenborg, Raina Yamamoto, Hans Christian Reinhardt, Alexander Röth, Victor Herbst, Yara Bestmann, Marco Kai, Jürgen E. Scherberich   +10 more
wiley   +1 more source

Taurine and Metabolic Diseases: Molecular Mechanisms and Therapeutic Implications

Food Frontiers, Volume 7, Issue 5, September 2026.
The dietary sources of taurine, as well as its protective effects and mechanisms in metabolism‐related diseases and metabolic disorder–associated ocular and cerebral injuries. ABSTRACT Taurine (Tau) is a sulfur‐containing amino acid prevalent in animal tissues and primarily acquired through dietary sources.
Xiaojie Ma, Zhijian Rao, Lifang Zheng
wiley   +1 more source

Autoimmunity: Molecular Mechanisms, Biomarkers, and Therapeutic Opportunities

MedComm, Volume 7, Issue 9, September 2026.
Major types of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming involved in autoimmune diseases. The roles of immunometabolism, epigenetics, posttranscriptional regulation, and functional reprogramming in autoimmune diseases have been a major research focus in recent years.
Jialong Kuang, Yin Zhu, Fang Xu, Yongjing Liu, Yuan Li, Ling Yuan, Liqin Wei, Bo Huang, Yan Chen, Pei Huang, Zuochen Du   +10 more
wiley   +1 more source

Protein Posttranslational Modifications in Immunity: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 9, September 2026.
Protein posttranslational modifications, including phosphorylation, ubiquitination, SUMOylation, acetylation, methylation, glycosylation, and other new types, dynamically regulate antigen presentation and recognition, immune signal transduction, antibody production and class switching, immune contraction, immune memory establishment, as well as immune ...
Yuxing Yao, Jinxiu Qian, Qiqiong Liu, Wanting Ye, Ying Xing, Xiuyun Bai, Rongjun Deng, Jue Yang, Cheng Lu, Cheng Xiao, Yuanyan Liu   +10 more
wiley   +1 more source

Tissue‐Resident Macrophage in Inflammation and Cancer

MedComm, Volume 7, Issue 9, September 2026.
Opposing macrophage functions in inflammation and cancer converge on shared mechanistic nodes, informing cross‐disease therapeutic strategies. ABSTRACT Tissue‐resident macrophages (TRMs) are long‐lived immune cells strategically distributed across organs, where their functional plasticity enables both homeostatic maintenance and pathological ...
Siyuan Huang, Jiangbo Fan, Wenyi Liu, Di Liu, Rui Wang, Yuanyang Wang, Jianhui Sun, Huacai Zhang, Qingli Cai, Zhe Xu, Fang Xu, Jianxin Jiang, Zhen Wang, Ling Zeng   +13 more
wiley   +1 more source