Some structural features of the peptide profile of myelin basic protein-hydrolyzing antibodies in schizophrenic patients [PDF]
PeerJ, 2023 The antibodies of schizophrenic patients that hydrolyze myelin basic protein (MBP) have been actively studied recently, but the mechanism of the catalytic properties of immunoglobulin molecules remains unknown.
Maria Zavialova +4 more
doaj +3 more sources
Autoantigen microarrays reveal myelin basic protein autoantibodies in morphea [PDF]
Journal of Translational Medicine, 2022 Background Morphea is an autoimmune, sclerosing skin disorder. Despite the recent emphasis on immune dysregulation in morphea, the role of autoantibodies in morphea pathogenesis or utility as biomarkers are poorly defined.
Jane L. Zhu +12 more
doaj +2 more sources
Comprehensive Atlas of the Myelin Basic Protein Interaction Landscape [PDF]
Biomolecules, 2021 Intrinsically disordered myelin basic protein (MBP) is one of the key autoantigens in autoimmune neurodegeneration and multiple sclerosis particularly.
Evgeniya V. Smirnova +6 more
doaj +2 more sources
Adhesion Process of Biomimetic Myelin Membranes Triggered by Myelin Basic Protein [PDF]
Frontiers in Chemistry, 2021 The myelin sheath—a multi-double-bilayer membrane wrapped around axons—is an essential part of the nervous system which enables rapid signal conduction.
Benjamin Krugmann +10 more
doaj +2 more sources
Myelin Basic Protein Post-Translational Modifications Orchestrate Astrocyte Regulatory Networks [PDF]
NeuroSciMultiple sclerosis (MS) pathogenesis involves not only immune-mediated myelin injury but also glial responses. We examined how three charge isomers of myelin basic protein (MBP)—native (C1), phosphorylated (C4), and citrullinated (C8)—modulate rat ...
Jeremy Ramsden +4 more
doaj +2 more sources
Identification of Myelin Basic Protein Proximity Interactome Using TurboID Labeling Proteomics [PDF]
Cells, 2023 Myelin basic protein (MBP) is one of the key structural elements of the myelin sheath and has autoantigenic properties in multiple sclerosis (MS).
Evgeniya V. Smirnova +6 more
doaj +2 more sources
Regional analysis of myelin basic protein across postnatal brain development of C57BL/6J mice [PDF]
Frontiers in NeuroanatomyHealthy brain development hinges on proper myelination, with disruption contributing to a wide array of neurological disorders. Immunohistochemical analysis of myelin basic protein (MBP) is a fundamental technique for investigating myelination and ...
Siddhi S. Ozarkar +12 more
doaj +2 more sources
Myelin Basic Protein and Cardiac Sympathetic Neurodegeneration in Nonhuman Primates [PDF]
Neurology Research International, 2021 Minimal myelination is proposed to be a contributing factor to the preferential nigral neuronal loss in Parkinson’s disease (PD). Similar to nigral dopaminergic neurons, sympathetic neurons innervating the heart have long, thin axons which are ...
Jeanette M. Metzger +8 more
doaj +2 more sources
Molecular characterization of myelin basic protein a (mbpa) gene from red-bellied pacu (Piaractus brachypomus) [PDF]
Journal of Genetic Engineering and Biotechnology, 2022 Background Myelin basic protein (MBP) is one of the most important structural components of the myelin sheaths in both central and peripheral nervous systems. MBP has several functions including organization of the myelin membranes, reorganization of the
Juan Sebastian Cruz-Méndez +3 more
doaj +2 more sources
Serum and Saliva Myelin Basic Protein as Multiple Sclerosis Biomarker [PDF]
Basic and Clinical Neuroscience, 2021 Introduction: Multiple Sclerosis (MS) is presented with motor and sensory function loss. It is caused by demyelination and following axonal lesion. As Myelin Basic Protein (MBP) is one of the key elements of the myelin cover, we examined the level of MBP
Mohammad Hossein Mirzaii-Dizgah +2 more
doaj +2 more sources