Adhesion Process of Biomimetic Myelin Membranes Triggered by Myelin Basic Protein [PDF]
Frontiers in Chemistry, 2021 The myelin sheath—a multi-double-bilayer membrane wrapped around axons—is an essential part of the nervous system which enables rapid signal conduction.
Benjamin Krugmann +10 more
doaj +9 more sources
Multiple sclerosis and myelin basic protein: insights into protein disorder and disease. [PDF]
Amino Acids, 2022 Myelin basic protein (MBP) is an abundant protein in central nervous system (CNS) myelin. MBP has long been studied as a factor in the pathogenesis of the autoimmune neurodegenerative disease multiple sclerosis (MS).
Martinsen V, Kursula P.
europepmc +2 more sources
Single-molecule tracking of myelin basic protein during oligodendrocyte differentiation [PDF]
Biological Imaging, 2023 This study aimed to expand our understanding of myelin basic protein (MBP), a key component of central nervous system myelin, by developing a protocol to track and quantifying individual MBP particles during oligodendrocyte (OL) differentiation.
Sayed M. Rassul +4 more
doaj +2 more sources
Myelin membrane assembly is driven by a phase transition of myelin basic proteins into a cohesive protein meshwork. [PDF]
PLoS Biology, 2013 Rapid conduction of nerve impulses requires coating of axons by myelin. To function as an electrical insulator, myelin is generated as a tightly packed, lipid-rich multilayered membrane sheath.
Shweta Aggarwal +11 more
doaj +2 more sources
Some structural features of the peptide profile of myelin basic protein-hydrolyzing antibodies in schizophrenic patients [PDF]
PeerJ, 2023 The antibodies of schizophrenic patients that hydrolyze myelin basic protein (MBP) have been actively studied recently, but the mechanism of the catalytic properties of immunoglobulin molecules remains unknown.
Maria Zavialova +4 more
doaj +3 more sources
Autoantigen microarrays reveal myelin basic protein autoantibodies in morphea [PDF]
Journal of Translational Medicine, 2022 Background Morphea is an autoimmune, sclerosing skin disorder. Despite the recent emphasis on immune dysregulation in morphea, the role of autoantibodies in morphea pathogenesis or utility as biomarkers are poorly defined.
Jane L. Zhu +12 more
doaj +2 more sources
Chronic Stress, 2018 Background Astrocytes and oligodendrocytes are pathologically altered in dorsolateral prefrontal and orbitofrontal cortices in major depressive disorder.
José Javier Miguel-Hidalgo +3 more
doaj +2 more sources
Comprehensive Atlas of the Myelin Basic Protein Interaction Landscape [PDF]
Biomolecules, 2021 Intrinsically disordered myelin basic protein (MBP) is one of the key autoantigens in autoimmune neurodegeneration and multiple sclerosis particularly.
Evgeniya V. Smirnova +6 more
doaj +2 more sources
Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases
Cell Reports, 2016 Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of the nervous system. We employed autoantibody-mediated animal models of demyelinating diseases, including a rat model of neuromyelitis optica (NMO), to target myelin ...
Marie-Theres Weil +13 more
doaj +2 more sources
Identification of Myelin Basic Protein Proximity Interactome Using TurboID Labeling Proteomics [PDF]
Cells, 2023 Myelin basic protein (MBP) is one of the key structural elements of the myelin sheath and has autoantigenic properties in multiple sclerosis (MS).
Evgeniya V. Smirnova +6 more
doaj +2 more sources