Results 1 to 10 of about 90,594 (330)

Some structural features of the peptide profile of myelin basic protein-hydrolyzing antibodies in schizophrenic patients [PDF]

PeerJ, 2023
The antibodies of schizophrenic patients that hydrolyze myelin basic protein (MBP) have been actively studied recently, but the mechanism of the catalytic properties of immunoglobulin molecules remains unknown.
Maria Zavialova, Daria Kamaeva, Laura Kazieva, Vladlen S. Skvortsov, Liudmila Smirnova   +4 more
doaj   +4 more sources

Identification of Myelin Basic Protein Proximity Interactome Using TurboID Labeling Proteomics [PDF]

Cells, 2023
Myelin basic protein (MBP) is one of the key structural elements of the myelin sheath and has autoantigenic properties in multiple sclerosis (MS).
Evgeniya V. Smirnova, Tatiana V. Rakitina, Rustam H. Ziganshin, George A. Saratov, Georgij P. Arapidi, Alexey A. Belogurov, Anna A. Kudriaeva   +6 more
doaj   +4 more sources

Autoantigen microarrays reveal myelin basic protein autoantibodies in morphea [PDF]

Journal of Translational Medicine, 2022
Background Morphea is an autoimmune, sclerosing skin disorder. Despite the recent emphasis on immune dysregulation in morphea, the role of autoantibodies in morphea pathogenesis or utility as biomarkers are poorly defined.
Jane L. Zhu, Ricardo T. Paniagua, Henry W. Chen, Stephanie Florez-Pollack, Elaine Kunzler, Noelle Teske, Yevgeniya Byekova Rainwater, Quan-Zhen Li, Gregory A. Hosler, Wenhao Li, Denise M. O. Ramirez, Nancy L. Monson, Heidi T. Jacobe   +12 more
doaj   +2 more sources

Comprehensive Atlas of the Myelin Basic Protein Interaction Landscape [PDF]

Biomolecules, 2021
Intrinsically disordered myelin basic protein (MBP) is one of the key autoantigens in autoimmune neurodegeneration and multiple sclerosis particularly.
Evgeniya V. Smirnova, Tatiana V. Rakitina, Rustam H. Ziganshin, Georgij P. Arapidi, George A. Saratov, Anna A. Kudriaeva, Alexey A. Belogurov   +6 more
doaj   +2 more sources

Adhesion Process of Biomimetic Myelin Membranes Triggered by Myelin Basic Protein [PDF]

Frontiers in Chemistry, 2021
The myelin sheath—a multi-double-bilayer membrane wrapped around axons—is an essential part of the nervous system which enables rapid signal conduction.
Benjamin Krugmann, Benjamin Krugmann, Alexandros Koutsioubas, Luman Haris, Luman Haris, Samantha Micciulla, Didier Lairez, Aurel Radulescu, Stephan Förster, Andreas M. Stadler, Andreas M. Stadler   +10 more
doaj   +2 more sources

Regional analysis of myelin basic protein across postnatal brain development of C57BL/6J mice [PDF]

Frontiers in Neuroanatomy
Healthy brain development hinges on proper myelination, with disruption contributing to a wide array of neurological disorders. Immunohistochemical analysis of myelin basic protein (MBP) is a fundamental technique for investigating myelination and ...
Siddhi S. Ozarkar, Siddhi S. Ozarkar, Ridthi K. R. Patel, Ridthi K. R. Patel, Tasmai Vulli, Tasmai Vulli, Carlee A. Friar, Carlee A. Friar, Alain C. Burette, Alain C. Burette, Benjamin D. Philpot, Benjamin D. Philpot, Benjamin D. Philpot   +12 more
doaj   +2 more sources

Myelin Basic Protein and a Multiple Sclerosis-related MBP-peptide Bind to Oligonucleotides [PDF]

Molecular Therapy: Nucleic Acids, 2014
Aptamer ligands for myelin basic protein (MBP) were obtained using the systematic evolution of ligand by exponential enrichment (SELEX) method. Two clones were isolated from a pool of oligonucleotides and tested for MBP targeting.
Guido Tomás Rozenblum, Tomás Kaufman, Alfredo Daniel Vitullo   +2 more
doaj   +2 more sources

Myelin Basic Protein and Cardiac Sympathetic Neurodegeneration in Nonhuman Primates [PDF]

Neurology Research International, 2021
Minimal myelination is proposed to be a contributing factor to the preferential nigral neuronal loss in Parkinson’s disease (PD). Similar to nigral dopaminergic neurons, sympathetic neurons innervating the heart have long, thin axons which are ...
Jeanette M. Metzger, Helen N. Matsoff, Don Vu, Alexandra D. Zinnen, Kathryn M. Jones, Viktoriya Bondarenko, Heather A. Simmons, Colleen F. Moore, Marina E. Emborg   +8 more
doaj   +2 more sources

Immunodominant fragments of myelin basic protein initiate T cell-dependent pain [PDF]

Journal of Neuroinflammation, 2012
Background The myelin sheath provides electrical insulation of mechanosensory Aβ-afferent fibers. Myelin-degrading matrix metalloproteinases (MMPs) damage the myelin sheath.
Liu Huaqing, Shiryaev Sergey A, Chernov Andrei V, Kim Youngsoon, Shubayev Igor, Remacle Albert G, Baranovskaya Svetlana, Golubkov Vladislav S, Strongin Alex Y, Shubayev Veronica I   +9 more
doaj   +2 more sources

Molecular characterization of myelin basic protein a (mbpa) gene from red-bellied pacu (Piaractus brachypomus) [PDF]

Journal of Genetic Engineering and Biotechnology, 2022
Background Myelin basic protein (MBP) is one of the most important structural components of the myelin sheaths in both central and peripheral nervous systems. MBP has several functions including organization of the myelin membranes, reorganization of the
Juan Sebastian Cruz-Méndez, María Paula Herrera-Sánchez, Ángel Enrique Céspedes-Rubio, Iang Schroniltgen Rondón-Barragán   +3 more
doaj   +2 more sources