Immunodominant fragments of myelin basic protein initiate T cell-dependent pain
Journal of Neuroinflammation, 2012 Background The myelin sheath provides electrical insulation of mechanosensory Aβ-afferent fibers. Myelin-degrading matrix metalloproteinases (MMPs) damage the myelin sheath.
Liu Huaqing +9 more
doaj +1 more source
Tumor microenvironment (Part I): Tissue integrity in a rat model of peripheral neural cancer [PDF]
Heliyon, Volume 10, Issue 13, e33932, July 15, 2024ICAM-1 (intercellular adhesion molecule 1) and MPZ (myelin protein zero) are thought to be a factor in the integrity of nerve tissues. In this report, we attempted to trace the expression of ICAM-1, responsible for cell-to-cell adhesion, and of MPZ, the main constituent of myelin sheath, in malignant tissues of the sciatic nerve (SN) in inbred male ...
arxiv +1 more source
Progress and Perspectives in 2D Piezoelectric Materials for Piezotronics and Piezo‐Phototronics
Advanced Science, EarlyView.This review examines advancements in 2D materials, focusing on their applications in piezotronics and piezo‐phototronics. It discusses key materials like TMDs, h‐BN, and phosphorene, highlighting their unique mechanical, electronic, and optical properties.
Fengyi Pang +6 more
wiley +1 more source
Effect of Sox10 on remyelination of the hippocampus in cuprizone‐induced demyelinated mice
Brain and Behavior, 2020 Objective The low number of oligodendrocytes (OLs) in the hippocampus of patients with schizophrenia suggests that hippocampal demyelination is changed in this condition. Sox10 is expressed throughout OL development.
Yu Shao +7 more
doaj +1 more source
High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection
Advanced Science, EarlyView.Mapping global epidemiological data to macronutrient supply reveals high carbohydrate, in contrast to high fat supply, associates with increased multiple sclerosis (MS) prevalence and incidence. This is confirmed in a mouse MS model, experimental autoimmune encephalomyelitis (EAE), using isocaloric diets: a high carbohydrate diet aggravates, a high ...
Duan Ni +15 more
wiley +1 more source
The lateral membrane organization and dynamics of myelin proteins PLP and MBP are dictated by distinct galactolipids and the extracellular matrix. [PDF]
PLoS ONE, 2014 In the central nervous system, lipid-protein interactions are pivotal for myelin maintenance, as these interactions regulate protein transport to the myelin membrane as well as the molecular organization within the sheath. To improve our understanding of
Hande Ozgen +7 more
doaj +1 more source
Tau Isoform-Driven CBD Pathology Transmission in Oligodendrocytes in Humanized Tau Mice
Frontiers in Neurology, 2021 The aggregation of abnormally phosphorylated tau protein in neurons and glia is a neuropathological hallmark of several neurodegenerative disorders, collectively known as tauopathies.
Justyna Zareba-Paslawska +4 more
doaj +1 more source
Single‐Cell Atlas Reveals Tumorigenic Profiles and Immune Dynamics of Adrenal Incidentalomas
Advanced Science, EarlyView.Single‐cell RNA sequencing reveals cellular heterogeneity in adrenal incidentalomas, identifying distinct tumor cell populations. Clusterin is recognized as a biomarker for adrenocortical tumors, correlating with established markers. MYCN‐positive clusters in pheochromocytomas indicated poorer survival.
Meng Wang +18 more
wiley +1 more source
gACSON software for automated segmentation and morphology analyses of myelinated axons in 3D electron microscopy [PDF]
arXiv, 2021 Background and Objective: Advances in electron microscopy (EM) now allow three-dimensional (3D) imaging of hundreds of micrometers of tissue with nanometer-scale resolution, providing new opportunities to study the ultrastructure of the brain. In this work, we introduce a freely available Matlab-based gACSON software for visualization, segmentation ...
arxiv
Label‐Free Dual‐Modal Photoacoustic/Ultrasound Localization Imaging for Studying Acute Kidney Injury
Advanced Science, EarlyView.This work develops a 3D label‐free photoacoustic/super‐resolution ultrasound imaging system as a comprehensive non‐invasive tool for acute kidney injury (AKI) study. This technique visualizes the intricate structure of renal microvessels and provides critical physiological insights, including renal hemodynamics and oxygenation.
Shensheng Zhao +5 more
wiley +1 more source