Results 91 to 100 of about 163,909 (218)

Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein

Annals of Neurology, 2018
ObjectiveAutoantibodies against myelin oligodendrocyte glycoprotein (MOG) occur in a proportion of patients with inflammatory demyelinating diseases of the central nervous system (CNS). We analyzed their pathogenic activity by affinity‐purifying these antibodies (Abs) from patients and transferring them to experimental animals.MethodsPatients with Abs ...
Spadaro, Melania, Winklmeier, Stephan, Beltrán, Eduardo, Macrini, Caterina, Höftberger, Romana, Schuh, Elisabeth, Thaler, Franziska S., Gerdes, Lisa Ann, Laurent, Sarah, Gerhards, Ramona, Brändle, Simone, Dornmair, Klaus, Breithaupt, Constanze, Krumbholz, Markus, Moser, Markus, Krishnamoorthy, Gurumoorthy, Kamp, Frits, Jenne, Dieter, Hohlfeld, Reinhard, Kümpfel, Tania, Lassmann, Hans, Kawakami, Naoto, Meinl, Edgar   +22 more
openaire   +6 more sources

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Is there an immunological cross-reactivity of antibodies to the myelin oligodendrocyte glycoprotein and coronaviruses? [PDF]

Recent reports indicated that myelin oligodendrocyte glycoprotein antibody-associated disease might be a rare complication after severe acute respiratory syndrome coronavirus 2 infection or vaccination.
Boso, Federica, Rudzki, Dagmar, Rossi, Patrizia, Rostasy, Kevin, Bauer, Angelika, Mariotto, Sara, Wendel, Eva-Maria, Wildemann, Brigitte, Kümpfel, Tania, Reindl, Markus, Schanda, Kathrin, Jarius, Sven, Engels, Daniel, Dinoto, Alessandro, Giometto, Bruno, Ferrari, Sergio   +15 more
core   +1 more source

The relationship between serum MOG-IgG titer status and titers and the prognosis of pediatric MOGAD: a retrospective cohort study

Frontiers in Pediatrics
BackgroundTo explore the clinical value of MOG-IgG serum titer change and duration in predicting the relapse of MOGAD in children.MethodsThe clinical data, imaging data and laboratory examination results of 63 children with MOGAD were analyzed, and the ...
Mengfan Pei, Yuyang He, Shan Huang, Cong Yao, Jing Chen, Lanhong Xiang, Chunhui Yuan, Hongmin Zhu   +7 more
doaj   +1 more source

The MacBrain Resource Center (MBRC) rhesus macaque postnatal brain histology datasets: Enabling new discoveries through NHP tissue and digital data Repositories

Journal of Anatomy, EarlyView.
The MacBrain Resource Center (MBRC) postnatal rhesus macaque brain histology datasets are organized into Collections that promote cost‐effective de novo research. This article provides examples from Collections 5, 6, and 7 and describes the histo‐ and immunohistochemical (IHC) processing of materials for Collection 6.
Valeria Mendoza‐Silva, Lucy Greene, Emma Burke, Cristina Canales, Julia Chocarro, Jose L. Lanciego, Khuleshwari Kurrey, Phil Barello, Aya Nusir, Nadine Kabbani, Kathleen S. Rockland, Dibyadeep Datta, Jon I. Arellano, Amy F. T. Arnsten, Yury M. Morozov, Bashir Ahmed, Zoltán Molnár, Caroline J. Zeiss, Pasko Rakic, Alvaro Duque   +19 more
wiley   +1 more source

beta1-integrin mediates myelin-associated glycoprotein signaling in neuronal growth cones

Molecular Brain, 2008
Several myelin-associated factors that inhibit axon growth of mature neurons, including Nogo66, myelin-associated glycoprotein (MAG) and oligodendrocyte myelin glycoprotein (OMgp), can associate with a common GPI-linked protein Nogo-66 receptor (NgR ...
Goh Eyleen LK, Young Ju, Kuwako Kenichiro, Tessier-Lavigne Marc, He Zhigang, Griffin John W, Ming Guo-li   +6 more
doaj   +1 more source

Frozen in Place: Proximity Labeling Maps Glial Interactomes Across Cell States

Glia, Volume 74, Issue 10, October 2026.
Proximity labeling enables cell‐type‐specific and spatially resolved mapping of glial protein networks. Proximity labeling approaches provide insights into glial function under physiological and pathological conditions. ABSTRACT Glial cells, including radial glia, oligodendrocyte precursor cells (OPCs), oligodendrocytes, astrocytes, and microglia, are ...
João Baltar, Rebecca Abati, Luísa Florido, Matthew G. Holt   +3 more
wiley   +1 more source

Anti-LGI1 encephalitis and co-existence of MOG-IgG: a case report and literature review

Frontiers in Human Neuroscience
BackgroundAnti-leucine-rich glioma-inactivated-1 (LGI1) encephalitis is an autoimmune disorder characterized by antibodies that target LGI1 (LGI1-IgG). It typically presents with cognitive impairment, psychiatric disturbances, and faciobrachial dystonic ...
Xiaojiao Ci, Liuyu Lin, Yuqing Wu, Yifang Ma, Jie Lu   +4 more
doaj   +1 more source

Simultaneous T2, T2*, and R2′ Mapping for Multiple Sclerosis Using Nonlinear Model‐Based Reconstruction of Undersampled Radial RARE‐EPI MRI

Magnetic Resonance in Medicine, Volume 96, Issue 4, Page 1872-1892, October 2026.
ABSTRACT Purpose To demonstrate the synergy of undersampled radial 2in1‐RARE‐EPI acquisition and nonlinear model‐based reconstruction for accelerated and simultaneous T2, T2*, and R2′ mapping in brains of patients with multiple sclerosis (MS). Methods 2in1‐RARE‐EPI combines a RARE module with an EPI module to capture T2 and T2* information.
Jose Raul Velasquez Vides, Carl J. J. Herrmann, Thomas Gladytz, Hoby P. Hetherington, Hendrik Mattern, Xiaoqing Wang, Jason M. Millward, Shahriar Shalikar, Igor Fabian Tellez Ceja, Beate Endemann, Sonia Waiczies, Joseph Kuchling, Friedemann Paul, Georg Rose, Min‐Chi Ku, Franz Schmitt, Thoralf Niendorf   +16 more
wiley   +1 more source

Anti-myelin oligodendrocyte glycoprotein antibody associated encephalitis

Rinsho Shinkeigaku, 2020
The recent development of a cell-based assay that can detect specific autoantibodies revealed the clinical features of diseases associated with the anti-myelin oligodendrocyte glycoprotein (MOG) antibody. The anti-MOG antibody associated diseases may include inflammatory demyelinating central nervous system diseases such as neuromyelitis optica ...
openaire   +3 more sources