Results 11 to 20 of about 5,673,942 (403)
Overview of myelin, major myelin lipids, and myelin-associated proteins
Frontiers in Chemistry, 2023 Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains the main characteristics of biological membranes, such as lipid bilayer, but differs from them in several important respects.
Alexander Kister, Ilya Kister
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White matter integrity in mice requires continuous myelin synthesis at the inner tongue
Nature Communications, 2022 Myelin is formed of proteins of long half-lives. The mechanisms of renewal of such a stable structure are unclear. Here, the authors show that myelin integrity requires continuous myelin synthesis at the inner tongue, contributing to the maintenance of a
Martin Meschkat +14 more
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Myelin Pathology: Involvement of Molecular Chaperones and the Promise of Chaperonotherapy [PDF]
Brain Sciences, 2019 The process of axon myelination involves various proteins including molecular chaperones. Myelin alteration is a common feature in neurological diseases due to structural and functional abnormalities of one or more myelin proteins.
Federica Scalia +4 more
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Oligodendrocytes express synaptic proteins that modulate myelin sheath formation
Nature Communications, 2019 Oligodendrocyte processes can detect and respond to axonal vesicular release. The authors here show in zebrafish that transsynaptic adhesion molecules, molecules that promote synapse formation and maturation in neurons, are expressed by oligodendrocytes ...
Alexandria N. Hughes, Bruce Appel
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Emergence of three myelin proteins in oligodendrocytes cultured without neurons. [PDF]
Journal of Cell Biology, 1986 Oligodendrocytes, the myelin-forming cells of the central nervous system, were cultured from newborn rat brain and optic nerve to allow us to analyze whether two transmembranous myelin proteins, myelin- associated glycoprotein (MAG) and proteolipid ...
Monique Dubois‐Dalcq +3 more
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Brain Sciences, 2022 Myelin in humans is composed of about 80% lipids and 20% protein. Initially, myelin protein composition was considered low, but various recent proteome analyses have identified additional myelin proteins.
Christos T. Chasapis +4 more
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Proteome Profile of Myelin in the Zebrafish Brain
Frontiers in Cell and Developmental Biology, 2021 The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice.
Sophie B. Siems +8 more
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Proteomic analysis of peripheral nerve myelin during murine aging
Frontiers in Cellular Neuroscience, 2023 Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy.
Dario Lucas Helbing +13 more
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eLife, 2022 Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to know to what extent the myelin protein composition has remained similar.
Vasiliki-Ilya Gargareta +12 more
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Mechanical Responses of a Single Myelin Layer: A Molecular Simulation Study
Biomolecules, 2023 The myelin sheath provides insulation to the brain’s neuron cells, which aids in signal transmission and communication with the body. Degenerated myelin hampers the connection between the glial cells, which are the front row responders during traumatic ...
Fairuz Maliha, Ashfaq Adnan
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