Results 31 to 40 of about 1,649,424 (250)

Loss of Myelin Basic Protein Function Triggers Myelin Breakdown in Models of Demyelinating Diseases

Cell Reports, 2016
Breakdown of myelin sheaths is a pathological hallmark of several autoimmune diseases of the nervous system. We employed autoantibody-mediated animal models of demyelinating diseases, including a rat model of neuromyelitis optica (NMO), to target myelin ...
Marie-Theres Weil, Wiebke Möbius, Anne Winkler, Torben Ruhwedel, Claudia Wrzos, Elisa Romanelli, Jeffrey L. Bennett, Lukas Enz, Norbert Goebels, Klaus-Armin Nave, Martin Kerschensteiner, Nicole Schaeren-Wiemers, Christine Stadelmann, Mikael Simons   +13 more
doaj   +1 more source

Severe central nervous system demyelination in Sanfilippo disease

Frontiers in Molecular Neuroscience, 2023
IntroductionChronic progressive neuroinflammation is a hallmark of neurological lysosomal storage diseases, including mucopolysaccharidosis III (MPS III or Sanfilippo disease).
Mahsa Taherzadeh, Mahsa Taherzadeh, Erjun Zhang, Irene Londono, Benjamin De Leener, Benjamin De Leener, Sophie Wang, Jonathan D. Cooper, Timothy E. Kennedy, Timothy E. Kennedy, Carlos R. Morales, Zesheng Chen, Gregory A. Lodygensky, Alexey V. Pshezhetsky, Alexey V. Pshezhetsky   +14 more
doaj   +1 more source

Structure of myelin P2 protein from equine spinal cord [PDF]

, 2005
Equine P2 protein has been isolated from horse spinal cord and its structure determined to 2.1 Å. Since equine myelin is a viable alternative to bovine tissue for large-scale preparations, characterization of the proteins from equine spinal cord ...
Riboldi-Tunnicliffe, A., Riboldi-Tunnicliffe, A, Freer, A.A., Hunter, DJB, Hunter, D.J.B., Griffiths, IR, Roszak, A.W., Macmaster, R, Roszak, AW, Macmaster, R., Griffiths, I.R., Freer, AA   +11 more
core   +1 more source

The Extracellular Matrix Proteins Tenascin-C and Tenascin-R Retard Oligodendrocyte Precursor Maturation and Myelin Regeneration in a Cuprizone-Induced Long-Term Demyelination Animal Model

Cells, 2022
Oligodendrocytes are the myelinating cells of the central nervous system. The physiological importance of oligodendrocytes is highlighted by diseases such as multiple sclerosis, in which the myelin sheaths are degraded and the axonal signal transmission ...
Juliane Bauch, Andreas Faissner
doaj   +1 more source

The Characterization of Disordered Membrane-Binding Proteins of Myelin. A Biophysical Approach [PDF]

, 2019
Myelin is a multilayered lipid-rich structure that surrounds selected axonal segments in the central and peripheral nervous systems (CNS and PNS, respectively).
Raasakka, Arne
core   +1 more source

Proteomics of the corpus callosum to identify novel factors involved in hypomyelinated Niemann-Pick Type C disease mice

Molecular Brain, 2019
Hypomyelination in the central nerves system (CNS) is one of the most obviously pathological features in Niemann-Pick Type C disease (NPC), which is a rare neurodegenerative disorder caused by mutations in the NPC intracellular cholesterol transporter 1 ...
Fan Yang, Yudong Guan, Xiao Feng, Arndt Rolfs, Hartmut Schlüter, Jiankai Luo   +5 more
doaj   +1 more source

Myelin organization in the nodal, paranodal, and juxtaparanodal regions revealed by scanning x-ray microdiffraction. [PDF]

PLoS ONE, 2014
X-ray diffraction has provided extensive information about the arrangement of lipids and proteins in multilamellar myelin. This information has been limited to the abundant inter-nodal regions of the sheath because these regions dominate the scattering ...
Hideyo Inouye, Jiliang Liu, Lee Makowski, Marilena Palmisano, Manfred Burghammer, Christian Riekel, Daniel A Kirschner   +6 more
doaj   +1 more source

Synthesis of antagonists of Myelin-associated glycoprotein (MAG) for conformational and SAR studies [PDF]

, 2004
Damage to the central nervous system (CNS) of higher vertebrates, including humans, often results in devastating and persistent functional deficits.
Gao, Gan-Pan
core   +1 more source

Cronassial Ameliorates Autoimmune Encephalomyelitis by Inhibiting Lipid Oxidation and Carbonyl Stress in the Brain and Spinal Cord of Rats

Biochemistry Research International, 2023
In recent years, the pathogenetic role of oxidative stress in damaging myelin cells, a precursor to the development of myelin-related diseases such as multiple sclerosis, has gained increasing significance. Experimental autoimmune encephalomyelitis (EAE)
Gayane Ghazaryan, Hasmik Zanginyan, Laura Hovsepyan, Artyom Azatyan, Maria Ghazaryan, Lusine Mardanyan   +5 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source