Results 51 to 60 of about 1,649,424 (250)

Myelin Pathology: Involvement of Molecular Chaperones and the Promise of Chaperonotherapy

Brain Sciences, 2019
The process of axon myelination involves various proteins including molecular chaperones. Myelin alteration is a common feature in neurological diseases due to structural and functional abnormalities of one or more myelin proteins.
Federica Scalia, Antonella Marino Gammazza, Everly Conway de Macario, Alberto J. L. Macario, Francesco Cappello   +4 more
doaj   +1 more source

The intrinsically disordered protein glue of the myelin major dense line: Linking AlphaFold2 predictions to experimental data

Biochemistry and Biophysics Reports, 2023
Numerous human proteins are classified as intrinsically disordered proteins (IDPs). Due to their physicochemical properties, high-resolution structural information about IDPs is generally lacking.
Oda C. Krokengen, Arne Raasakka, Petri Kursula   +2 more
doaj   +1 more source

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Nogo receptor is involved in the adhesion of dendritic cells to myelin

Journal of Neuroinflammation, 2011
Background Nogo-66 receptor NgR1 and its structural homologue NgR2 are binding proteins for a number of myelin-associated inhibitory factors. After neuronal injury, these inhibitory factors are responsible for preventing axonal outgrowth via their ...
Martin Roland, Schweigreiter Rüdiger, Kern Florian, Steinbach Karin, McDonald Claire L, Bandtlow Christine E, Reindl Markus   +6 more
doaj   +1 more source

The lateral membrane organization and dynamics of myelin proteins PLP and MBP are dictated by distinct galactolipids and the extracellular matrix. [PDF]

PLoS ONE, 2014
In the central nervous system, lipid-protein interactions are pivotal for myelin maintenance, as these interactions regulate protein transport to the myelin membrane as well as the molecular organization within the sheath. To improve our understanding of
Hande Ozgen, Waldemar Schrimpf, Jelle Hendrix, Jenny C de Jonge, Don C Lamb, Dick Hoekstra, Nicoletta Kahya, Wia Baron   +7 more
doaj   +1 more source

Ofatumumab in Myelin Oligodendrocyte Glycoprotein Antibody–Associated Disease: A Comparison With Rituximab

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To evaluate the efficacy and safety of ofatumumab in patients with myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), and compare it with rituximab. Methods We conducted a single–center, observational study including 22 MOGAD patients treated with ofatumumab and 21 treated with rituximab.
Yuxin Fan, Lei Zhou, Jingzi ZhangBao, Hongmei Tan, Zhouzhou Wang, Chao Quan   +5 more
wiley   +1 more source

Time-lapse imaging of the dynamics of CNS glial-axonal interactions in vitro and ex vivo [PDF]

, 2012
<b>Background</b> Myelination is an exquisite and dynamic example of heterologous cell-cell interaction, which consists of the concentric wrapping of multiple layers of oligodendrocyte membrane around neuronal axons.
Strachan, D., Susan C Barnett, Edgar Julia M., David Strachan (186501), Ioannidou, K., Julia M Edgar, Kurt I Anderson, Susan C. Barnett (186504), David Strachan, Julia M. Edgar (37537), Anderson, K.I., Barnett, S.C., Strachan David, Kalliopi Ioannidou, Kurt I. Anderson (186499), Edgar, J.M., Kalliopi Ioannidou (186497), Ioannidou Kalliopi, Anderson Kurt I., Barnett Susan C.   +19 more
core   +1 more source

Lipid metabolism in myelinating glial cells: lessons from human inherited disorders and mouse models

Journal of Lipid Research, 2011
The integrity of central and peripheral nervous system myelin is affected in numerous lipid metabolism disorders. This vulnerability was so far mostly attributed to the extraordinarily high level of lipid synthesis that is required for the formation of ...
Roman Chrast, Gesine Saher, Klaus-Armin Nave, Mark H.G. Verheijen   +3 more
doaj   +1 more source

Tropomyosin Receptor Kinase B Expressed in Oligodendrocyte Lineage Cells Functions to Promote Myelin Following a Demyelinating Lesion

ASN Neuro, 2020
The levels of brain-derived neurotrophic factor (BDNF) in the corpus callosum have previously been shown to have a critical impact on oligodendrocyte (OLG) lineage cells during cuprizone-elicited demyelination. In particular, BDNF+/– mice exhibit greater
Yangyang Huang, Yeri J. Song, Maria Isaac, Shir Miretzky, Ashish Patel, W. Geoffrey McAuliffe, Cheryl F. Dreyfus   +6 more
doaj   +1 more source

Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5

eLife, 2022
Oligodendrocytes facilitate rapid impulse propagation along the axons they myelinate and support their long-term integrity. However, the functional relevance of many myelin proteins has remained unknown.
Tobias J Buscham, Maria A Eichel-Vogel, Anna M Steyer, Olaf Jahn, Nicola Strenzke, Rakshit Dardawal, Tor R Memhave, Sophie B Siems, Christina Müller, Martin Meschkat, Ting Sun, Torben Ruhwedel, Wiebke Möbius, Eva-Maria Krämer-Albers, Susann Boretius, Klaus-Armin Nave, Hauke B Werner   +16 more
doaj   +1 more source