Results 61 to 70 of about 119,819 (305)

Hypomyelinating leukodystrophy-associated mutation of RARS leads it to the lysosome, inhibiting oligodendroglial morphological differentiation

Biochemistry and Biophysics Reports, 2019
Pelizaeus-Merzbacher disease (PMD) is a central nervous system (CNS) demyelinating disease in human, currently known as prototypic hypomyelinating leukodystrophy 1 (HLD1).
Naoto Matsumoto, Natsumi Watanabe, Noriko Iibe, Yuriko Tatsumi, Kohei Hattori, Yu Takeuchi, Hiroaki Oizumi, Katsuya Ohbuchi, Tomohiro Torii, Yuki Miyamoto, Junji Yamauchi   +10 more
doaj   +1 more source

The intrinsically disordered protein glue of the myelin major dense line: Linking AlphaFold2 predictions to experimental data

Biochemistry and Biophysics Reports, 2023
Numerous human proteins are classified as intrinsically disordered proteins (IDPs). Due to their physicochemical properties, high-resolution structural information about IDPs is generally lacking.
Oda C. Krokengen, Arne Raasakka, Petri Kursula   +2 more
doaj   +1 more source

Placental Mesenchymal Stem Cell-Derived Extracellular Vesicles Promote Myelin Regeneration in an Animal Model of Multiple Sclerosis. [PDF]

, 2019
Mesenchymal stem/stromal cells (MSCs) display potent immunomodulatory and regenerative capabilities through the secretion of bioactive factors, such as proteins, cytokines, chemokines as well as the release of extracellular vesicles (EVs).
Barthe, Sylvain, Clark, Kaitlin, Farmer, Diana, Guo, Fuzheng, Kreutzberg, Nicole, Kumar, Priyadarsini, Paxton, Zachary, Pivetti, Christopher, Reed, Camille, Wang, Aijun, Wang, Yan, Zhang, Sheng   +11 more
core   +2 more sources

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Evidence for gliadin antibodies as causative agents in schizophrenia. [PDF]

, 2010
Antibodies to gliadin, a component of gluten, have frequently been reported in schizophrenia. Highly immunogenic B cell epitopes along its length are homologous to numerous proteins relevant to schizophrenia, including members of the DISC1 interactome ...
Chris J. Carter
core   +2 more sources

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Autoimmune responses to myelin-associated proteins as diagnostic and prognostic biomarkers of relapsing-remitting multiple sclerosis: Associations with human herpesvirus-6 and Epstein-Barr virus reactivation

Journal of Advanced Research
Background: The pathogenesis of relapsing-remitting multiple sclerosis (RRMS) is linked to autoimmune attacks against myelin proteins, and reactivation of Epstein-Barr virus (EBV) and human herpesvirus 6 (HHV-6).
Aristo Vojdani, Abbas F. Almulla, Elroy Vojdani, Jing Li, Yingqian Zhang, Michael Maes   +5 more
doaj   +1 more source

Nogo receptor is involved in the adhesion of dendritic cells to myelin

Journal of Neuroinflammation, 2011
Background Nogo-66 receptor NgR1 and its structural homologue NgR2 are binding proteins for a number of myelin-associated inhibitory factors. After neuronal injury, these inhibitory factors are responsible for preventing axonal outgrowth via their ...
Martin Roland, Schweigreiter Rüdiger, Kern Florian, Steinbach Karin, McDonald Claire L, Bandtlow Christine E, Reindl Markus   +6 more
doaj   +1 more source

Progressive axonopathy when oligodendrocytes lack the myelin protein CMTM5

eLife, 2022
Oligodendrocytes facilitate rapid impulse propagation along the axons they myelinate and support their long-term integrity. However, the functional relevance of many myelin proteins has remained unknown.
Tobias J Buscham, Maria A Eichel-Vogel, Anna M Steyer, Olaf Jahn, Nicola Strenzke, Rakshit Dardawal, Tor R Memhave, Sophie B Siems, Christina Müller, Martin Meschkat, Ting Sun, Torben Ruhwedel, Wiebke Möbius, Eva-Maria Krämer-Albers, Susann Boretius, Klaus-Armin Nave, Hauke B Werner   +16 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source