Results 71 to 80 of about 1,649,424 (250)

A Magneto‐Mechanically Activated Nerve Guidance Conduit Promotes Peripheral Nerve Regeneration via TIMP1‐Mediated Membrane Tension Transfer

Advanced Functional Materials, EarlyView.
This study presents a magneto‐mechanical strategy that incorporates FP@MSCs into an aligned PCL/GelMA nerve guidance conduit. Magnetic stimulation increases membrane tension in FP@MSCs, triggering cytoskeletal remodeling, Schwann cell‐like differentiation, and TIMP1 secretion. TIMP1 activates ITGB1/CD63–FAK signaling in NE‐4C cells, increasing membrane
Xinyu Zhu, Yumin Wu, Xiang Gao, Tianlu Wang, Wanting Jia, Xueying Mei, Huanzhong Ji, Zongxi Wu, Yujie Liang, Xiang Li, Kan Li, Jingyuan Li, Guangsen Zheng, Guiqing Liao, Siyong Gao   +14 more
wiley   +1 more source

Myelin proteins from the peripheral nervous system : Structures and interactions with lipid membrane [PDF]

Saltare (å hoppe) beskriver den grunnleggende funksjonen myelin har i nervesystemet. Myelin er en flerlaget fettmembran som omslutter nervecellenes aksoner og effektiviserer signalformidlingen betraktelig ved å øke hastigheten til nerveimpulser ...
Krokengen, Oda Caspara
core   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Ionizable Lipid‐Dependent Optimization of Steroid Lipid Nanoparticles With Tunable Immunomodulatory Properties

Advanced Materials, EarlyView.
A novel engineering strategy that establishes material design principles for incorporating anti‐inflammatory steroids into lipid nanoparticles to reduce LNP‐induced inflammation while retaining mRNA delivery. Results are validated in vitro and in three animal models of inflammation and autoimmunity in vivo.
Ajay S. Thatte, Benjamin E. Nachod, Julia Baena, Jenna Muscat‐Rivera, Lesley Chaboub, Hannah C. Safford, Hannah C. Geisler, Hannah M. Yamagata, Melgious J. Y. Ang, Michael Kegel, Alexandre Poirier, Elaine R. Tong, Zhe Zhong, Qiangqiang Shi, Jinjin Wang, Elisa Battistini, Ye Zeng, Alex G. Hamilton, Kelsey L. Swingle, Drew Weissman, Jilian R. Melamed, Michael J. Mitchell   +21 more
wiley   +1 more source

Bioengineered Interfaces for Peripheral Nerve Sensory Restoration

Advanced Materials, EarlyView.
Half of amputees abandon their prosthetics for lack of feeling. This review charts the full path from peripheral nerve injury to restored sensation, through surgical, regenerative, noninvasive, and implanted approaches, and shows how injury type and interface material properties determine which strategy can deliver naturalistic feedback, and why ...
Sydney Swedick, Salim El Hadwe, Kesi Liang, George G. Malliaras, Damiano G. Barone   +4 more
wiley   +1 more source

Intelligent Micro/Nanorobots for Targeted Interventional Therapy: From Bench to Clinic

Advanced Robotics Research, EarlyView.
Zirui Zhang et al. reviewed the application and challenges of mobile nanomachines in interventional therapy. By converting exogenous energy, including chemical, magnetic, optical, and ultrasonic sources, into mechanical forces, micro/nanorobots (MNRs) enable precise actuation at unprecedented scales. Evolving far beyond traditional drug delivery, these
Zirui Zhang, Yu Dong, Yongsheng Du, Rui Gao, Lin Zhang, Fei Tong   +5 more
wiley   +1 more source

Analogous amino acid sequences in myelin proteolipid and viral proteins [PDF]

, 1986
Computer analysis of the intrinsic membrane protein, myelin proteolipid, shows strong sequence similarities between the putative extramembrane segments of the proteolipid protein and a number of viral proteins, several of which infect humans.
Shyh-Yu Shaw, Shaw, Shyh-Yu, Laursen, Richard A., Lees, Marjorie B., Richard A. Laursen, Marjorie B. Lees   +5 more
core   +1 more source

Reliability of radiomics features as imaging biomarkers for evaluating brain aging: A study based on myelin protein and diffusion tensor imaging

NeuroImage
Radiomics has made considerable progress in neurodegenerative diseases. However, previous studies only explored the feasibility of radiomics in clinical applications.
Yuting Yan, Mengmeng Hu, Xiaodong He, Yuyun Xu, Xiaojun Sun, Jiaxuan Peng, Fanfan Zhao, Yuan Shao   +7 more
doaj   +1 more source

Mr BMT Achieves Systemic Macrophage Replacement With Preservation of Tissue Homeostasis

Advanced Science, EarlyView.
Microglia replacement by bone marrow transplantation (Mr BMT) enables systemic replacement of tissue‐resident macrophages. Despite persistent macrophage and tissue remodeling across multiple organs, core biological functions and innate immune responses remain preserved, supporting long‐term maintenance of organismal homeostasis and the therapeutic ...
Yufei Xu, Miaozhan Zou, Yunshang Bai, Yang He, Zhihao Jin, Baozhi Yang, Jinjin Du, Pei Ouyang, Yuanyuan Cai, Yuheng Zhang, Bingying Du, Chengcheng Ge, Jian‐an Gong, Xiaoyu Li, Yuanyi Zheng, Jing Ding, Bo Peng, Yanxia Rao   +17 more
wiley   +1 more source

Quantitative and integrative proteome analysis of peripheral nerve myelin identifies novel myelin proteins and candidate neuropathy loci [PDF]

, 2011
Peripheral nerve myelin facilitates rapid impulse conduction and normal motor and sensory functions. Many aspects of myelin biogenesis, glia-axonal interactions, and nerve homeostasis are poorly understood at the molecular level.
Aguzzi, A., Schwab, Markus H., Ingo Bormuth, De Monasterio-Schrader, P., Kuo Yan, de Monasterio-Schrader, Patricia, Schwab, M., Möbius, W., Hesse, Dörte, Nave, K A, Schwab, M H, Juliane Bremer, Bormuth, I., Yan, Kuo, Wichert, Sven P., Bremer, J., Möbius, Wiebke, Patzig, J, Markus H. Schwab, Foteini Orfaniotou, Nave, K., de Monasterio-Schrader, P, Stefan Tenzer, Dörte Hesse, Wichert, S P, Rosfa, S, Yan, K, Werner, H B, Jahn, Olaf, Tenzer, S, Jahn, O., Jörg Kuharev, Rosfa, Susanne, Wichert, S., Patzig, J., Hesse, D., Adriano Aguzzi, Aguzzi, Adriano, Nave, Klaus-Armin, Orfaniotou, Foteini, Sven P. Wichert, Yan, K., Bremer, Juliane, Rosfa, S., Bormuth, I, Orfaniotou, F, Olaf Jahn, Wiebke Möbius, Kuharev, J, Werner, Hauke Bernhard, Möbius, W, Orfaniotou, F., Bormuth, Ingo, Jahn, O, Tenzer, Stefan, Hesse, D, Patricia de Monasterio-Schrader, Kuharev, Jörg, Julia Patzig, Susanne Rosfa, Werner, H., Aguzzi, A; https://orcid.org/, Bremer, J, Klaus-Armin Nave, Patzig, Julia, Kuharev, J., Hauke Bernhard Werner, Tenzer, S.   +67 more
core   +1 more source