Results 11 to 20 of about 119,819 (305)

Overview of myelin, major myelin lipids, and myelin-associated proteins

Frontiers in Chemistry, 2023
Myelin is a modified cell membrane that forms a multilayer sheath around the axon. It retains the main characteristics of biological membranes, such as lipid bilayer, but differs from them in several important respects.
Alexander Kister, Ilya Kister
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Myelin Pathology: Involvement of Molecular Chaperones and the Promise of Chaperonotherapy [PDF]

Brain Sciences, 2019
The process of axon myelination involves various proteins including molecular chaperones. Myelin alteration is a common feature in neurological diseases due to structural and functional abnormalities of one or more myelin proteins.
Federica Scalia, Antonella Marino Gammazza, Everly Conway de Macario, Alberto J. L. Macario, Francesco Cappello   +4 more
doaj   +3 more sources

Multi-omics validation of myelin water fraction as a myelin-specific MRI biomarker [PDF]

NeuroImage
The myelin sheath is critical for efficient neural signaling and central nervous system function, yet noninvasive methods to quantify myelin content in vivo require robust biological validation. Myelin Water Fraction (MWF) derived from the Bayesian Monte
Jonghyun Bae, Cassandra M. Joynes, Zhaoyuan Gong, Michael R. Duggan, Keenan A. Walker, Mustapha Bouhrara   +5 more
doaj   +2 more sources

The Human Myelin Proteome and Sub-Metalloproteome Interaction Map: Relevance to Myelin-Related Neurological Diseases

Brain Sciences, 2022
Myelin in humans is composed of about 80% lipids and 20% protein. Initially, myelin protein composition was considered low, but various recent proteome analyses have identified additional myelin proteins.
Christos T. Chasapis, Konstantinos Kelaidonis, Harry Ridgway, Vasso Apostolopoulos, John M. Matsoukas   +4 more
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Proteome Profile of Myelin in the Zebrafish Brain

Frontiers in Cell and Developmental Biology, 2021
The velocity of nerve conduction along vertebrate axons depends on their ensheathment with myelin. Myelin membranes comprise specialized proteins well characterized in mice.
Sophie B. Siems, Olaf Jahn, Laura J. Hoodless, Ramona B. Jung, Dörte Hesse, Wiebke Möbius, Wiebke Möbius, Tim Czopka, Hauke B. Werner   +8 more
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Proteomic analysis of peripheral nerve myelin during murine aging

Frontiers in Cellular Neuroscience, 2023
Aging of the peripheral nervous system (PNS) is associated with structural and functional changes that lead to a reduction in regenerative capacity and the development of age-related peripheral neuropathy.
Dario Lucas Helbing, Dario Lucas Helbing, Dario Lucas Helbing, Dario Lucas Helbing, Dario Lucas Helbing, Joanna M. Kirkpatrick, Michael Reuter, Julia Bischoff, Amy Stockdale, Annemarie Carlstedt, Emilio Cirri, Reinhard Bauer, Helen Morrison, Helen Morrison   +13 more
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Conservation and divergence of myelin proteome and oligodendrocyte transcriptome profiles between humans and mice

eLife, 2022
Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to know to what extent the myelin protein composition has remained similar.
Vasiliki-Ilya Gargareta, Josefine Reuschenbach, Sophie B Siems, Ting Sun, Lars Piepkorn, Carolina Mangana, Erik Späte, Sandra Goebbels, Inge Huitinga, Wiebke Möbius, Klaus-Armin Nave, Olaf Jahn, Hauke B Werner   +12 more
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The CNS Myelin Proteome: Deep Profile and Persistence After Post-mortem Delay

Frontiers in Cellular Neuroscience, 2020
Myelin membranes are dominated by lipids while the complexity of their protein composition has long been considered to be low. However, numerous additional myelin proteins have been identified since.
Olaf Jahn, Sophie B. Siems, Kathrin Kusch, Dörte Hesse, Ramona B. Jung, Thomas Liepold, Marina Uecker, Ting Sun, Hauke B. Werner   +8 more
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Mechanical Responses of a Single Myelin Layer: A Molecular Simulation Study

Biomolecules, 2023
The myelin sheath provides insulation to the brain’s neuron cells, which aids in signal transmission and communication with the body. Degenerated myelin hampers the connection between the glial cells, which are the front row responders during traumatic ...
Fairuz Maliha, Ashfaq Adnan
doaj   +1 more source

Enzymic methylation of myelin basic protein in myelin [PDF]

Biochemical Journal, 1991
Myelin fractions with different degrees of compaction were isolated from bovine brain, and post-translational methylation of membrane-associated proteins was studied. When the purified myelin-basic-protein-specific protein methylase I and S-adenosyl-L-[methyl-14C]methionine were added exogenously, the most compact myelin fraction exhibited higher ...
S K, Ghosh, N, Rawal, S K, Syed, W K, Paik, S D, Kim   +4 more
openaire   +2 more sources