Results 221 to 230 of about 119,819 (305)

Exportin 1 Inhibitor Combined With Venetoclax Induces Apoptosis in Myelodysplastic Syndrome by Mitochondria‐Induced Apoptosis Pathway

Journal of Clinical Laboratory Analysis, EarlyView.
Inhibition of XPO1 is a promising modality in the treatment of MDS, especially when combined with Venetoclax, which activates mitochondria‐mediated apoptosis and could be a potential target for MDS therapy. ABSTRACT Background Myelodysplastic syndromes (MDS) are clonal hematopoietic malignancies that pose a serious health threat.
Xiaohan Liu, Lei Huang, Junzhu Wang, Yixuan Guo, Hongli Shen, Xianghong Zhao, Lanzhu Yue, Zhaoyun Liu, Rong Fu   +8 more
wiley   +1 more source

FGF4 activates FGFR1 - PI3K/AKT signaling to enhance Clec10a-mediated intracellular myelin debris processing and promote spinal cord repair. [PDF]

J Neuroinflammation
Lu W, Jiang M, Zhuang J, Song J, Zhou C, Zhou Y, Zhu Z, Wu A, Sheng S, Zhu S, Wang Z.   +10 more
europepmc   +1 more source

A Morphological Study of Restoration of Damaged Hair Fiber With Chemical Treatments Using Microscopy Techniques

Microscopy Research and Technique, EarlyView.
Assessment of Restoring Chemically Damaged Hair Fibers Using Microscopy and Spectroscopy. ABSTRACT This paper analyses hair restoration products currently on the market that treat chemically processed hair. This study measured the restoration of structural integrity in hair samples from both chemically damaged hair (chemically relaxed, bleached, and ...
L. P. A. Mauricio, R. A. D. Cunha, S. M. Alves   +2 more
wiley   +1 more source

Teriflunomide Attenuates Demyelination and Enhances Remyelination in Organotypic Brain Slice Cultures Through Modulation of Glial Cell Dynamics. [PDF]

CNS Neurosci Ther
Kronenberg J, Schröder LJ, Reinsberg H, Skripuletz T, Heckers S, Hansmann F, Baumgärtner W, Stangel M, Gudi V.   +8 more
europepmc   +1 more source

The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion‐Tensor‐Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurological disorders affecting older adults, with approximately 7.2 million cases only in the United States. This number is projected to increase to 13.8 million in the United States by 2060, leading to increased expenditures for healthcare, long‐term care and hospice services. Consequently,
Valentina Zecca, Gianmauro Palombelli, Nicola Vanacore, Rossella Canese   +3 more
wiley   +1 more source

Sertraline can alleviate neuronal and synaptic damage in the hippocampus of PTSD mice and inhibit the increase in myelin. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Lu J, Yang L, Lu K, Xing W, Hu M, Zhang G.   +5 more
europepmc   +1 more source

Probiotic consumption reduces alveolar bone loss and kidney damage in pregnant rats with experimental periodontitis

Journal of Periodontology, EarlyView.
Abstract Background Bifidobacterium animalis subsp. lactis HN019 (B. lactis HN019) is a probiotic bacterial strain with immunomodulatory properties. Its benefits have been observed in healthy and systemically compromised animals with periodontitis (PD). Our objective was to investigate the local and systemic effects of the systemic administration of B.
Átila V. V. Nobre, Pedro H. F. Silva, Marina C. G. Del‐Arco, Raquel F. Gerlach, Rene S. Oliezer, José E. Tanus‐Santos, Luciene C. Figueiredo, Janaina S. A. M. Evangelista, Flávia A. C. Furlaneto, Michel R. Messora, Sérgio Luiz Salvador   +10 more
wiley   +1 more source

Klotho Function in Neurogenesis and Oligodendrogenesis: A Mini-Review Update. [PDF]

J Mol Neurosci
Possebom IR, Dos Santos GRO, Kawamoto EM.   +2 more
europepmc   +1 more source

Alterations in brain metabolites in rats with experimental periodontitis: A metabolomic approach

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis (PD) is a chronic inflammatory disease with systemic effects. Emerging evidence suggests a link between periodontal inflammation and neurological changes, but the biochemical mechanisms in key brain regions, such as the hippocampus and amygdala, remain unclear.
Ramona Ramalho de Souza Pereira, Caíque Olegário Diniz e Magalhães, Elizabeth Luciana Marinho Miguel, Larissa Vieira Toledo, Débora Ribeiro Orlando, Alan Rodrigues Teixeira Machado, Bruno Del Bianco Borges, Luciano José Pereira, Marco Fabrício Dias‐Peixoto, Eric Francelino Andrade   +9 more
wiley   +1 more source

Molecular and biochemical correlates of frontal lobe white matter degeneration in humans with alcohol use disorder. [PDF]

Adv Drug Alcohol Res
de la Monte SM, Tong M, Sutherland G.
europepmc   +1 more source