Results 251 to 260 of about 119,819 (305)
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Isoprenylated Proteins in Myelin
Journal of Neurochemistry, 1994Abstract: Incubation of rat brainstem slices with [3H]‐ mevalonate ([3H]MVA) in the presence of lovastatin resulted in the incorporation of label into three groups of myelin‐associated proteins with molecular masses of 47, 21–27, and 8 kDa, as revealed on sodium dodecyl sulfate‐ polyacrylamide rod gel electrophoresis.
L, Sepp-Lorenzino +2 more
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Journal of Neuroscience Research, 2014
Human P0 is the main myelin glycoprotein of the peripheral nervous system. It can bind six different glycans, all linked to Asn93, the unique glycosylation site. Other myelin glycoproteins, also with a single glycosylation site (PMP22 at Asn36, MOG at Asn31), bind only one glycan.
Sedzik J +2 more
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Human P0 is the main myelin glycoprotein of the peripheral nervous system. It can bind six different glycans, all linked to Asn93, the unique glycosylation site. Other myelin glycoproteins, also with a single glycosylation site (PMP22 at Asn36, MOG at Asn31), bind only one glycan.
Sedzik J +2 more
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Scandinavian Journal of Immunology, 1982
Our attention was first directed to a study of myelin proteins because of our interest in the induction of experimental allergic encephalomyelitis (EAE) and the fact that Kabat et al. (11) and Morgan (26) had reported that white matter was more encephalitogenic than gray matter.
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Our attention was first directed to a study of myelin proteins because of our interest in the induction of experimental allergic encephalomyelitis (EAE) and the fact that Kabat et al. (11) and Morgan (26) had reported that white matter was more encephalitogenic than gray matter.
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1981
Myelin basic protein (MBP) has engaged the attention of molecular and cellular immunologists during the past decade because of its implication in the induction of the autoimmune disease experimental allergic encephalomyelitis (EAE) of the central nervous system (CNS).
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Myelin basic protein (MBP) has engaged the attention of molecular and cellular immunologists during the past decade because of its implication in the induction of the autoimmune disease experimental allergic encephalomyelitis (EAE) of the central nervous system (CNS).
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Immune Tolerance to Myelin Proteins
Immunologic Research, 2003Multiple sclerosis (MS) is a demyelinating disorder of the central nervous system. It is believed to be an autoimmune disease arising from a breakdown of immune tolerance in T cells specific for myelin antigens. The heterogeneity in clinical signs and pathology observed in MS patients suggests a complex pathogenesis in which the specificity of the ...
Audrey, Seamons +2 more
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1977
The protein composition of CNS myelin is relatively simple, with two protein fractions comprising 60–80% of the total membrane protein. These are the highly basic, histonelike protein (a single protein in most animals, two in some species) and the hydrophobic proteolipid protein fraction (predominantly a single protein).
Peter E. Braun, Steven W. Brostoff
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The protein composition of CNS myelin is relatively simple, with two protein fractions comprising 60–80% of the total membrane protein. These are the highly basic, histonelike protein (a single protein in most animals, two in some species) and the hydrophobic proteolipid protein fraction (predominantly a single protein).
Peter E. Braun, Steven W. Brostoff
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Crystallization of P2 myelin protein
Journal of Molecular Biology, 1987Single crystals of bovine P2 myelin protein have been grown in polyethylene glycol 4000 by the hanging-drop vapor diffusion method. Crystals belonging to space group P2(1)2(1)2(1) with cell dimensions a = 91.8 A, b = 99.5 A, c = 56.5 A (1 A = 0.1 nm). The diffraction pattern extends to better than 2.3 A resolution.
T, Bergfors +5 more
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Myelin breakdown and basic protein
Experimental Neurology, 1974Abstract The purpose of the present work was to study the mechanisms of myelin breakdown in experimental conditions and the fate of protein components in myelin, especially that of myelin basic protein which is known to be important in demyelinative disorders. The results showed that when myelin was incubated alone without any added enzymes there was
M, Röyttä +4 more
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Autoimmunity to Myelin Basic Protein
1982Experimental allergic encephalomyelitis (EAE) is an autoimmune central nervous system (CNS) disease which has been studied extensively, and has provided insight into mechanisms of immune tissue damage and immunologic self-tolerance. In addition, EAE serves as a prototype for human demyelinating diseases such as multiple sclerosis1.
R H, Swanborg, J H, Holda, J A, Killen
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Myelin basic protein interacts with the myelin-specific ganglioside GM4
Brain Research, 1981Demyelinated plaques in multiple sclerosis have decreased amounts of both myelin basic protein and sialosylgalactosylceramide (GM4), a ganglioside specifically localized in myelin and oligodendroglia of the central nervous system. We have found that myelin basic protein is capable of releasing large quantities of entrapped [14C]glucose from ...
B R, Mullin +3 more
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