Results 171 to 180 of about 43,575 (246)

Very long chain sphingolipids govern brain myelination by regulating oligodendrocyte differentiation and membrane microdomain integrity. [PDF]

J Transl Med
Sun H, Mo L, Cao M, Tian Y, Mo L, Ni Z, Zhang S, Huang X, Wang Y, Lam SM, Shui G.   +10 more
europepmc   +1 more source

Diffusion Tensor Imaging and Fiber Tractography Analysis in Patients with Pelizaeus-Merzbacher Disease. [PDF]

Noro Psikiyatr Ars
Erdoğan HA, Dinçer A, Topaloğlu P, Acır İ, Yapıcı Z.   +4 more
europepmc   +1 more source

Targeted attack: Harnessing myelin-specific plasmolipin for suppression of neuroblastoma and glioblastoma. [PDF]

Mol Ther Oncol
Spirin P, Shulgin A, Lebedev T, Zheltukhin A, Leonova O, Popenko V, Rubtsov P, Sprang B, Giese A, Stocking C, Kim E, Prassolov V.   +11 more
europepmc   +1 more source

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Myelin proteolipid protein—the first 50 years

The International Journal of Biochemistry & Cell Biology, 2002
Myelin proteolipid protein (PLP), the most abundant protein of central nervous system (CNS) myelin, is a hydrophobic integral membrane protein. Because of its physical properties, which make it difficult to work with, progress towards determining the exact function(s) and disease associations of myelin PLP has been slow.
Greer, Judith M., Lees, Marjorie B.
semanticscholar   +6 more sources

Myelin proteolipid protein induces demyelinating disease in mice

Journal of the Neurological Sciences, 1987
Using two methods of immunization (A and B), 5/10 (A) and 27/45 (B), BALB/c by J mice immunized with human myelin proteolipid protein developed a demyelinating disease with a spectrum of chronic progressive to relapsing-remitting courses. Demyelinative lesions were seen histopathologically in all clinically affected animals that were examined.
J L, Trotter, H B, Clark, K G, Collins, C L, Wegeschiede, J D, Scarpellini   +4 more
openaire   +3 more sources

Novel neuronal proteolipid protein isoforms encoded by the human myelin proteolipid protein 1 gene

Neuroscience, 2010
The human myelin proteolipid protein 1 gene (hPLP1), which encodes the major structural myelin proteins of the central nervous system (CNS), is classically described as expressed in the oligodendrocytes, the CNS myelinating cells. We identified two new exons in the intron 1 of the hPLP1 gene that lead to the expression of additional mRNA and protein ...
C, Sarret, P, Combes, P, Micheau, A, Gelot, O, Boespflug-Tanguy, C, Vaurs-Barriere   +5 more
openaire   +3 more sources

Maintenance of high proteolipid protein level in adult central nervous system myelin is required to preserve the integrity of myelin and axons

Glia, 2019
Proteolipid protein (PLP) is the most abundant integral membrane protein in central nervous system (CNS) myelin. Expression of the Plp‐gene in oligodendrocytes is not essential for the biosynthesis of myelin membranes but required to prevent axonal ...
K. Lüders, S. Nessler, Kathrin Kusch, J. Patzig, Ramona B. Jung, W. Möbius, K. Nave, H. Werner   +7 more
semanticscholar   +3 more sources

Electroblot analysis of the myelin proteolipid protein

Journal of Neuroscience Research, 1982
AbstractThe myelin proteolipid has been studied by the electroblot method of Towbin et al [1979]. Samples were separated by SDS–polyacrylamide gel electrophoresis, transferred to nitrocellulose, and incubated with proteolipid antibody. The proteolipid band could be identified immunologically in CNS myelin and in whole brain homogenates.
W B, Macklin, P E, Braun, M B, Lees
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Structure and expression of the mouse myelin proteolipid protein gene

Journal of Neuroscience Research, 1987
AbstractThe gene for the mouse myelin proteolipid protein has been isolated and the seven exons have been sequenced. Since the sequence of a rat proteolipid protein cDNA and partial sequence of the human proteolipid protein gene have been determined, it was possible to demonstrate a very high degree of conservation for the protelipid protein gene exons
W B, Macklin, C W, Campagnoni, P L, Deininger, M V, Gardinier   +3 more
openaire   +3 more sources

Immunogenic and encephalitogenic epitope clusters of myelin proteolipid protein

The Journal of Immunology, 1996
Abstract To understand and develop strategies to intervene in autoimmune responses to myelin proteolipid protein (PLP), encephalitogenic epitopes must be identified. To expedite the identification of potentially immunogenic and encephalitogenic epitopes of PLP, overlapping synthetic 20-mer PLP peptides covering the whole PLP molecule ...
Greer, JM, Sobel, RA, Sette, A, Southwood, S, Lees, MB, Kuchroo, VK   +5 more
openaire   +3 more sources