Results 181 to 190 of about 43,575 (246)
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Journal of Neuroscience Research, 1987
AbstractContrary to widely held beliefs, the gene encoding proteolipid protein (PLP), the major structural protein of central nervous system myelin, is ecpressed in Schwann cells and their tumors. Proteolipid mRNA was identified in human acoustic neuromas and in rat and rabbit sciatic nerves using a human PLP cDNA as probe.
C, Puckett +6 more
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AbstractContrary to widely held beliefs, the gene encoding proteolipid protein (PLP), the major structural protein of central nervous system myelin, is ecpressed in Schwann cells and their tumors. Proteolipid mRNA was identified in human acoustic neuromas and in rat and rabbit sciatic nerves using a human PLP cDNA as probe.
C, Puckett +6 more
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Nucleotide sequences of two mRNAs for rat brain myelin proteolipid protein.
Cell, 1985R. J. Milner +5 more
semanticscholar +3 more sources
Molecular Evolution of Myelin Proteolipid Protein
Biochemical and Biophysical Research Communications, 1997We show that the major membrane protein of central nervous system myelin, proteolipid protein, evolved much more rapidly than it does now more than 300 million years ago. We reason that myelin proteolipid protein evolved rapidly just after its appearance in vertebrates and that its evolutionary rate then gradually decreased.
T, Kurihara, M, Sakuma, T, Gojobori
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Intracellular Translocation of Myelin Proteolipid Protein
Journal of Neurochemistry, 1985Abstract: Brainstem slices prepared from 22‐day‐old rats, were employed to study the intracellular translocation of radioactively labeled myelin proteolipid protein (PLP). Double‐isotope and short pulse‐chase procedures allowed us to demonstrate the flux of PLP through nine different subcellular membrane fractions that were isolated on the basis of ...
G, Konat +3 more
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Minireview: Autoimmune responses to myelin proteolipid protein
Neurochemical Research, 1994The authors present a brief historical sketch of the development of our understanding of immune responses to myelin proteolipid protein (PLP) and the acceptance of PLP as a potent antigen in the induction of experimental allergic encephalomyelitis (EAE). The distinct characteristics of the PLP molecule that may contribute to complex immune responses to
Sobel, RA, Greer, JM, Kuchroo, VK
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Developmental Neuroscience, 1998
Sequences from the first intron of the mouse myelin proteolipid protein (PLP) gene were examined for their ability to modulate PLP gene expression. Glial (N20.1) or nonglial (NIH 3T3) cells were transiently transfected with constructs that contained 1.4 kb of PLP promoter sequence driving luciferase reporter gene expression, as well as various portions
P A, Wight, A, Dobretsova
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Sequences from the first intron of the mouse myelin proteolipid protein (PLP) gene were examined for their ability to modulate PLP gene expression. Glial (N20.1) or nonglial (NIH 3T3) cells were transiently transfected with constructs that contained 1.4 kb of PLP promoter sequence driving luciferase reporter gene expression, as well as various portions
P A, Wight, A, Dobretsova
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Interaction of myelin basic protein and proteolipid protein
Journal of Neuroscience Research, 1989AbstractThe interaction of myelin basic protein (MBP) and proteolipid protein (PLP) was studied using a microtitre well binding assay and the ligand‐blot overlay technique. The binding of iodinated PLP to MBP that was immobilized on microtitre wells was saturable and reversible.
A M, Edwards +3 more
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