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Spectroscopic analysis of acylated and deacylated myelin proteolipid protein
Biochemistry, 1986The effect of covalently bound fatty acid on the conformation of the myelin proteolipid protein has been studied by ultraviolet and intrinsic fluorescence spectroscopy. With dimethyl sulfoxide used as a perturbant, the exposure of Trp and Tyr residues in various mixtures of chloroform-methanol was evaluated by difference spectroscopy of the proteolipid
O A, Bizzozero, M B, Lees
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A synthetic peptide from myelin proteolipid protein induces experimental allergic encephalomyelitis.
Journal of Immunology, 1988Immunization of animals with proteolipid protein, the major protein constituent of central nervous system myelin, produces experimental allergic encephalomyelitis.
V. Tuohy +4 more
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Myelination in the Absence of Galactolipids and Proteolipid Proteins
Molecular and Cellular Neuroscience, 1999The galactolipids galactocerebroside and sulfatide and the proteolipid protein (PLP) and its splice variant DM20 are the most abundant lipid and protein components of central nervous system myelin. Recent studies have found that mice lacking either the galactolipids or PLP are able to form myelin sheaths with apparently normal periodicity and near ...
Coetzee, T. +3 more
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Increased turnover of myelin proteolipid protein in quaking mouse brain
Metabolic Brain Disease, 1987Homozygous quaking and normal control littermate mice were injected intracerebrally with [3H]leucine at 19 days of age. The animals were sacrificed after 1 h and after 6 days. The proteolipid protein (PLP) and intermediate protein (IP) were extracted from whole brain by chloroform-methanol (2:1) and resolved by sodium dodecyl sulfate-polyacrylamide gel
G, Konat, G, Gantt, E L, Hogan
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Cysteine-108 is an acylation site in myelin proteolipid protein
Biochemical and Biophysical Research Communications, 1990Myelin proteolipid protein (PLP) contains covalently bound long-chain fatty acids. A large proportion of these acyl moieties are bound in thioester linkages, as demonstrated by alkylation of newly formed SH groups upon deacylation. To identify the Cys residue(s) involved in the thioester linkage(s), reduced and carboxyamidomethylated proteolipid ...
O A, Bizzozero, L K, Good, J E, Evans
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Electrophoretic Analysis of Myelin Proteolipid Protein and Its Deacylated Form
Journal of Neurochemistry, 1985Abstract: Myelin proteolipid protein is known to contain covalently bound fatty acid. To determine the contribution of the fatty acid to the multiple bands observed on sodium dodecyl sulfate–polyacrylamide gel electrophoresis, the electrophoretic parameters of the proteolipid protein were compared with those of the deacylated form.
O A, Bizzozero +3 more
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Immunochemical characterization of antibodies to the myelin proteolipid protein (PLP)
Journal of Neuroimmunology, 1988The immunochemical specificity of antibodies raised against the bovine myelin proteolipid protein (PLP) and a series of PLP synthetic peptides was examined by enzyme-linked immunosorbent assay (ELISA) and immunoblot analyses. Polyclonal rabbit anti-bovine PLP antibodies were cross-reactive with PLP isolated from rat, monkey, and human CNS white matter,
N T, Potter, M B, Lees
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X‐ray diffraction analysis of myelin lipid/proteolipid protein multilayers
Journal of Neuroscience Research, 1989AbstractTo examine the proposal that myelin proteolipid protein underlies the adhesion of neighboring membranes in central nervous system (CNS) myelin, we carried out X‐ray diffraction studies on the structure and interactions of model bilayers composed of total myelin lipids plus proteolipid apoprotein (PLP).
F R, Brown +3 more
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Orientation of myelin proteolipid protein in the oligodendrocyte cell membrane
Neurochemical Research, 1996The orientation of proteins within a cell membrane can often be difficult to determine. A number of models have been proposed for the orientation of the myelin protein, proteolipid protein (PLP), each of which includes exposed domains on the intracellular and extracellular membrane faces. Immunolabeling experiments have localized the C-terminus and the
Greer, JM +4 more
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Myelin structure in proteolipid protein (PLP)-null mouse spinal cord
The Journal of Comparative Neurology, 1996Fixed preparations of proteolipid protein (PLP)-null mouse spinal cord show myelin sheaths which in some regions consist of typical alternating major dense lines (MDLs) and intermediate lines (ILs) with a repeat period of 10.3 nm. More commonly, the lamellar structure consists of what appears to be a single population of dense lines, having a repeat ...
J, Rosenbluth, W, Stoffel, R, Schiff
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