Results 71 to 80 of about 6,136 (180)

A Spatially Resolved View on the Aging Substantia nigra: An Exploratory Proteomic Study

Advanced Biology, Volume 9, Issue 12, December 2025.
Although aging is the most important risk factor for several neurodegenerative diseases, the molecular effects of physiological aging are still understudied. By applying spatially‐resolved proteomic analyses of the human substantia nigra pars compacta, alterations in vesicular trafficking and mitochondrial proteins are observed, as well as reduced ...
Britta Eggers, Maximilian Hausherr, Michel Lim, Karin Schork, Bilhan Karacora, Robin Grugel, Martin Eisenacher, Isabel Gil Aldea, Peter Riederer, Manfred Gerlach, Katrin Marcus   +10 more
wiley   +1 more source

Sonic Hedgehog Is an Early Oligodendrocyte Marker During Remyelination

Cells
Failure of myelin regeneration by oligodendrocytes contributes to progressive decline in many neurological diseases. Here, using in vitro and in vivo rodent models, functional blockade, and mouse brain demyelination, we demonstrate that Sonic hedgehog ...
Mariagiovanna Russo, Amina Zahaf, Abdelmoumen Kassoussi, Ariane Sharif, Hélène Faure, Elisabeth Traiffort, Martial Ruat   +6 more
doaj   +1 more source

Knockdown of Unconventional Myosin ID Expression Induced Morphological Change in Oligodendrocytes

ASN Neuro, 2016
Myelin is a special multilamellar structure involved in various functions in the nervous system. In the central nervous system, the oligodendrocyte (OL) produces myelin and has a unique morphology.
Reiji Yamazaki, Tomoko Ishibashi, Hiroko Baba, Yoshihide Yamaguchi   +3 more
doaj   +1 more source

The Effect of Melatonin on Behavioral, Molecular, and Histopathological Changes in Cuprizone Model of Demyelination [PDF]

, 2016
Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system. The protective effects of melatonin (MLT) on various neurodegenerative diseases, including MS, have been suggested.
Ghadiri, T., Ghaemi, A., Gorji, A., Khodagholi, F., Noorbakhsh, F., Sharifzadeh, M., Vakilzadeh, G.   +6 more
core  

Peptide/Antibody–Drug Conjugates for Therapeutic Applications in Inflammatory Disease

Advanced NanoBiomed Research, Volume 5, Issue 12, December 2025.
Peptide/antibody–drug conjugates (PADCs) combine ligand specificity and cleavable linkers to deliver drugs precisely to disease sites with minimal toxicity. While current approvals focus on oncology, this review examines their untapped potential in inflammatory diseases, detailing mechanisms of targeted delivery and highlighting advances that position ...
Yeongji Jang, Jiwoong Choi, Youngri Ryu, Hyun Kyu Song, Man Kyu Shim, Yoosoo Yang   +5 more
wiley   +1 more source

Analogous amino acid sequences in myelin proteolipid and viral proteins [PDF]

FEBS Letters, 1986
Computer analysis of the intrinsic membrane protein, myelin proteolipid, shows strong sequence similarities between the putative extramembrane segments of the proteolipid protein and a number of viral proteins, several of which infect humans. These similarities are even more striking than those reported previously between viral proteins and the ...
Shaw, Shyh-Yu, Laursen, Richard A., Lees, Marjorie B.   +2 more
openaire   +2 more sources

Pelizaeus-Merzbacher Disease in a 4-Year-Old Female Child: “A Rare Case Report”

Global Pediatric Health, 2023
Pelizaeus-Merzbacher disease, a rare X-linked recessive disease occurring predominantly in males, is a disorder of proteolipid protein expression in myelin formation in the central nervous system.
Devesh Gagan MBBS, MD Pediatrics, Sudesh Kumar MD Pediatrics, Piyali Bhattacharya MD Pediatrics, Simranjit Kaur MBBS, MD Pediatrics   +3 more
doaj   +1 more source

Effect Of Gender On T-Cell Proliferative Responses To Myelin Proteolipid Protein Antigens In Patients With Multiple Sclerosis And Controls [PDF]

, 2004
Multiple sclerosis (MS) is an inflammatory demyelinating disorder of the central nervous system. Gender influences both susceptibility to MS, with the disease being more common in women, and the clinical course of disease, with an increased proportion of
Acarin, Amadori, Arnold, Baxevanis, Brinkman, Budinger, Burns, Burns, Burns, Cheng, Cutolo, Deibler, Derbinski, Fox, Goebels, Greer, Hammond, Hattori, Hauben, Huygen, Johnson, Judith M. Greer, Keegan, Kerlero de Rosbo, Lacroix-Desmazes, Lisak, Lombardi, Lovett-Racke, Macklin, Markovic-Plese, Mata, Melcangi, Michael P. Pender, Mock, Ng, O'Connor, Pamela A. McCombe, Pelfrey, Pender, Pender, Pender, Pender, Peter A. Csurhes, Poser, Runmarker, Sadatipour, Scholz, Schwartz, Seo, Stinissen, Takahashi, Tejada-Simon, Tejada-Simon, Tornwall, Trotter, Weinshenker, Weinstein, Willard, Zamvil   +58 more
core   +1 more source

Unraveling the Role of Ensheathing Cells and Perineural Fibroblasts in Olfactory Neurogenesis

Glia, Volume 73, Issue 12, Page 2407-2426, December 2025.
Main Points DEOs are similar to satellite glial cells. DECs react to neuronal injury by promoting lipid metabolism, but do not proliferate. ECs reduce gap junctions upon neuronal injury. Perineural fibroblasts also contribute to the injury response. ABSTRACT During development and following injury‐induced neurogenesis, olfactory ensheathing cells (OECs)
Katja Senf, Sandor Nietzsche, Martin Westermann, Eva M. Neuhaus   +3 more
wiley   +1 more source

Deficiency of MicroRNA-23-27-24 Clusters Exhibits the Impairment of Myelination in the Central Nervous System

Neural Plasticity, 2023
Several microRNAs (miRNAs), including miR-23 and miR-27a have been reportedly involved in regulating myelination in the central nervous system. Although miR-23 and miR-27a form clusters in vivo and the clustered miRNAs are known to perform complementary ...
Yuji Tsuchikawa, Naosuke Kamei, Yohei Sanada, Toshio Nakamae, Takahiro Harada, Kazunori Imaizumi, Takayuki Akimoto, Shigeru Miyaki, Nobuo Adachi   +8 more
doaj   +1 more source