Results 151 to 160 of about 5,726 (179)
InCytokine, an Open-Source Software, Reveals a TREM2 Variant-Specific Cytokine Signature. [PDF]
Int J Mol SciJha D +10 more
europepmc +1 more source
Proximity Labelling Reveals the Compartmental Proteome of Murine Sensory Neurons. [PDF]
Eur J PainSondermann JR +9 more
europepmc +1 more source
Myelin: Methods for Purification and Proteome Analysis [PDF]
Methods in Molecular Biology, 2019 Molecular characterization of myelin is a prerequisite for understanding the normal structure of the axon/myelin-unit in the healthy nervous system and abnormalities in myelin-related disorders. However, reliable molecular profiles necessitate very pure myelin membranes, in particular when considering the power of highly sensitive "omics"-data ...
Dorte Hesse +2 more
exaly +7 more sources
Myelin Proteomics: Molecular Anatomy of an Insulating Sheath [PDF]
Molecular Neurobiology, 2009 Fast-transmitting vertebrate axons are electrically insulated with multiple layers of nonconductive plasma membrane of glial cell origin, termed myelin. The myelin membrane is dominated by lipids, and its protein composition has historically been viewed to be of very low complexity.
Olaf Jahn +2 more
exaly +7 more sources
Quantitative and Integrative Proteome Analysis of Peripheral Nerve Myelin Identifies Novel Myelin Proteins and Candidate Neuropathy Loci [PDF]
Journal of Neuroscience, 2011 Peripheral nerve myelin facilitates rapid impulse conduction and normal motor and sensory functions. Many aspects of myelin biogenesis, glia–axonal interactions, and nerve homeostasis are poorly understood at the molecular level. We therefore hypothesized that only a fraction of all relevant myelin proteins has been identified so far.
Olaf Jahn +2 more
exaly +8 more sources
Systematic approaches to central nervous system myelin
Cellular and Molecular Life Sciences, 2012 Rapid signal propagation along vertebrate axons is facilitated by their insulation with myelin, a plasma membrane specialization of glial cells.
Olaf Jahn +2 more
exaly +2 more sources
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Lipidome and proteome map of myelin membranes
Journal of Neuroscience Research, 2012AbstractTo understand the molecular anatomy of myelin membranes, we performed a large‐scale, liquid chromatography‐coupled tandem mass spectrometry (LC‐MS/MS)‐based lipidome and proteome screen on freshly purified human and murine myelin fractions. We identified more than 700 lipid moieties and above 1,000 proteins in the two species, including 284 ...
Gopakumar, Gopalakrishnan +6 more
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Proteomic Mapping of the Human Myelin Proteome
2021Alzheimer's disease (AD) is a degenerative cognitive condition that affects individuals with an increasing prevalence in older age groups. There are currently five drugs on the market for AD but no new effective ones have been discovered for decades.
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