Results 171 to 180 of about 13,094 (201)
Endocytome profiling uncovers cell-surface protein dynamics underlying neuronal connectivity. [PDF]
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Proteomic Mapping of the Human Myelin Proteome
2021Alzheimer's disease (AD) is a degenerative cognitive condition that affects individuals with an increasing prevalence in older age groups. There are currently five drugs on the market for AD but no new effective ones have been discovered for decades.
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New observations on the compact myelin proteome
Neuron Glia Biology, 2005Myelin formation and maintenance depends on the establishment of two structurally and biochemically discernible domains: (a) compact myelin, that is multilamellar stacks of plasma membrane sheets; and (b) cytoplasmic channels that border the compact myelin domains, attach them to the cell body and anchor the myelin sheath to the axonal membrane.
Alejandro D, Roth +2 more
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Lipidome and proteome map of myelin membranes
Journal of Neuroscience Research, 2012AbstractTo understand the molecular anatomy of myelin membranes, we performed a large‐scale, liquid chromatography‐coupled tandem mass spectrometry (LC‐MS/MS)‐based lipidome and proteome screen on freshly purified human and murine myelin fractions. We identified more than 700 lipid moieties and above 1,000 proteins in the two species, including 284 ...
Gopakumar, Gopalakrishnan +6 more
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Functional degradation of myelin basic protein. The proteomic approach
Russian Journal of Bioorganic Chemistry, 2011Proteolytic degradation of autoantigens is of prime importance in current biochemistry and immunology. The most fundamental issue in this field is the functional role of peptides produced when the specificity of hydrolysis changes during the shift from health to disease and from normal state to pathology.
A V, Bacheva +7 more
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Proteomics Analysis of Myelin Composition
2018The identification and functional characterization of the repertoire of myelin proteins provides a valuable foundation for understanding molecular mechanisms of myelination and the pathogenesis of human myelin disease. Here we provide a procedure for the purification of myelin from rodent or human brains and a large-scale analysis of the myelin ...
Akihiro, Ishii +2 more
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Myelin proteomics: the past, the unexpected and the future
Expert Review of Proteomics, 2014Myelin proteomics has been the subject of intense research over the last decade, and its profiling has achieved good results by both in-gel and mass spectrometry-based techniques. 1280 proteins have been identified, a number expected to increase. Some of the identified proteins are as yet not established as true components of myelin.
I. Panfoli +6 more
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An overview of the human brain myelin proteome and differences associated with schizophrenia
The World Journal of Biological Psychiatry, 2020Disturbances in the myelin sheath drive disruptions in neural transmission and brain connectivity as seen in schizophrenia. Here, the myelin proteome was characterised in schizophrenia patients and healthy controls to visualise differences in proteomic profiles.A liquid chromatography tandem mass spectrometry-based shotgun proteomic analysis was ...
Daniel Martins-de-Souza +5 more
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Myelin Proteome Analysis: Methods and Implications for the Myelin Cytoskeleton
2012Myelin, the multilayered membrane that enwraps and insulates neuronal axons for fast signal propagation, is a plasma membrane specialization of oligodendrocytes and Schwann cells in the central and peripheral nervous system, respectively. Here we provide our lab protocols for the puri fi cation of myelin from mouse brains and for gel-based and gel-free
Jahn, O. +4 more
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