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Myelin: Methods for Purification and Proteome Analysis [PDF]
Methods in Molecular Biology, 2019 Molecular characterization of myelin is a prerequisite for understanding the normal structure of the axon/myelin-unit in the healthy nervous system and abnormalities in myelin-related disorders.
Olaf Jahn +2 more
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Quantitative and Integrative Proteome Analysis of Peripheral Nerve Myelin Identifies Novel Myelin Proteins and Candidate Neuropathy Loci [PDF]
Journal of Neuroscience, 2011 Peripheral nerve myelin facilitates rapid impulse conduction and normal motor and sensory functions. Many aspects of myelin biogenesis, glia-axonal interactions, and nerve homeostasis are poorly understood at the molecular level.
Julia Pätzig +2 more
exaly +8 more sources
Human myelin proteome and comparative analysis with mouse myelin [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2009 Myelin, formed by oligodendrocytes (OLs) in the CNS, is critical for axonal functions, and its damage leads to debilitating neurological disorders such as multiple sclerosis. Understanding the molecular mechanisms of myelination and the pathogenesis of human myelin disease has been limited partly by the relative lack of identification and functional ...
Bruce Trapp +2 more
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Myelin Proteomics: Molecular Anatomy of an Insulating Sheath [PDF]
Molecular Neurobiology, 2009 Fast-transmitting vertebrate axons are electrically insulated with multiple layers of nonconductive plasma membrane of glial cell origin, termed myelin. The myelin membrane is dominated by lipids, and its protein composition has historically been viewed to be of very low complexity.
Olaf Jahn +2 more
exaly +5 more sources
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Proteomic Mapping of the Human Myelin Proteome
2021Alzheimer's disease (AD) is a degenerative cognitive condition that affects individuals with an increasing prevalence in older age groups. There are currently five drugs on the market for AD but no new effective ones have been discovered for decades.
openaire +2 more sources
Myelin proteomics: the past, the unexpected and the future
Expert Review of Proteomics, 2014Myelin proteomics has been the subject of intense research over the last decade, and its profiling has achieved good results by both in-gel and mass spectrometry-based techniques. 1280 proteins have been identified, a number expected to increase. Some of the identified proteins are as yet not established as true components of myelin.
I. Panfoli +6 more
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Lipidome and proteome map of myelin membranes
Journal of Neuroscience Research, 2012AbstractTo understand the molecular anatomy of myelin membranes, we performed a large‐scale, liquid chromatography‐coupled tandem mass spectrometry (LC‐MS/MS)‐based lipidome and proteome screen on freshly purified human and murine myelin fractions. We identified more than 700 lipid moieties and above 1,000 proteins in the two species, including 284 ...
Gopakumar, Gopalakrishnan +6 more
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New observations on the compact myelin proteome
Neuron Glia Biology, 2005Myelin formation and maintenance depends on the establishment of two structurally and biochemically discernible domains: (a) compact myelin, that is multilamellar stacks of plasma membrane sheets; and (b) cytoplasmic channels that border the compact myelin domains, attach them to the cell body and anchor the myelin sheath to the axonal membrane.
Alejandro D, Roth +2 more
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An overview of the human brain myelin proteome and differences associated with schizophrenia
The World Journal of Biological Psychiatry, 2020Disturbances in the myelin sheath drive disruptions in neural transmission and brain connectivity as seen in schizophrenia. Here, the myelin proteome was characterised in schizophrenia patients and healthy controls to visualise differences in proteomic profiles.A liquid chromatography tandem mass spectrometry-based shotgun proteomic analysis was ...
Daniel Martins-de-Souza +5 more
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Proteomics Analysis of Myelin Composition
2018The identification and functional characterization of the repertoire of myelin proteins provides a valuable foundation for understanding molecular mechanisms of myelination and the pathogenesis of human myelin disease. Here we provide a procedure for the purification of myelin from rodent or human brains and a large-scale analysis of the myelin ...
Akihiro, Ishii +2 more
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