Results 161 to 170 of about 5,726 (179)

New observations on the compact myelin proteome

Neuron Glia Biology, 2005
Myelin formation and maintenance depends on the establishment of two structurally and biochemically discernible domains: (a) compact myelin, that is multilamellar stacks of plasma membrane sheets; and (b) cytoplasmic channels that border the compact myelin domains, attach them to the cell body and anchor the myelin sheath to the axonal membrane.
Alejandro D, Roth, Anna, Ivanova, David R, Colman   +2 more
openaire   +2 more sources

Proteomics Analysis of Myelin Composition

2018
The identification and functional characterization of the repertoire of myelin proteins provides a valuable foundation for understanding molecular mechanisms of myelination and the pathogenesis of human myelin disease. Here we provide a procedure for the purification of myelin from rodent or human brains and a large-scale analysis of the myelin ...
Akihiro, Ishii, David, Han, Rashmi, Bansal   +2 more
openaire   +2 more sources

Functional degradation of myelin basic protein. The proteomic approach

Russian Journal of Bioorganic Chemistry, 2011
Proteolytic degradation of autoantigens is of prime importance in current biochemistry and immunology. The most fundamental issue in this field is the functional role of peptides produced when the specificity of hydrolysis changes during the shift from health to disease and from normal state to pathology.
A V, Bacheva, A A, Belogurov, E S, Kuzina, M V, Serebriakova, N A, Ponomarenko, V D, Knorre, V M, Govorun, A G, Gabibov   +7 more
openaire   +2 more sources

Author response: Proteome profile of peripheral myelin in healthy mice and in a neuropathy model

, 2019
Olaf Jahn, Nirmal Kannaiyan, Kathrin Kusch   +2 more
exaly   +2 more sources

A proteomic approach to rapidly elucidate oligodendrocyte-associated proteins expressed in the myelinating rat optic nerve

ELECTROPHORESIS, 2002
The lack of cDNA libraries derived from myelinating oligodendrocytes has hampered attempts to identify proteins associated with myelination during normal development or with remyelination after insult or disease. We, therefore, established a new method to elucidate such proteins by coupling the techniques of X-irradiation, two-dimensional (2-D) gel ...
Raymond J, Colello, Babette, Fuss, Michael A, Fox, James, Alberti   +3 more
openaire   +2 more sources

An approach to comprehensive genome and proteome expression analyses in Schwann cells and neurons during peripheral nerve myelin formation

Journal of Neurochemistry, 2016
AbstractPeripheral nerve myelination is a complex event resulting from spatially and temporally regulated reciprocal interactions between the neuron and myelin‐forming Schwann cells. The dynamic process and the protein functional modules and networks that operate throughout the myelination process are poorly understood because of a lack of ...
Salla M Kangas, Steffen Ohlmeier, RAIJA Sormunen   +2 more
exaly   +5 more sources

Proteomics of the corpus callosum unravel pivotal players in the dysfunction of cell signaling, structure, and myelination in schizophrenia brains

European Archives of Psychiatry and Clinical Neuroscience, 2015
Schizophrenia is an incurable and debilitating mental disorder that may affect up to 1% of the world population. Morphological, electrophysiological, and neurophysiological studies suggest that the corpus callosum (CC), which is the largest portion of white matter in the human brain and responsible for inter-hemispheric communication, is altered in ...
Saia-Cereda, V., Cassoli, J., Schmitt, A., Falkai, P. ; https://orcid.org/0000-0003-2873-8667, Nascimento, J., Martins-de-Souza, D.   +5 more
openaire   +3 more sources

Exploitation of detergent thermodynamics in the direct solubilization of myelin membrane proteins for two‐dimensional gel electrophoresis for proteomic analysis

ELECTROPHORESIS, 2011
AbstractPerforming 2‐DE of lipid‐rich multilamellar membranes like myelin is a cumbersome task. However, for understanding its molecular organization and changes during diseases, identification of proteins of myelin is essential. Although the 2‐D‐proteomic approach of myelin has been employed to understand the myelin proteome, representation of myelin ...
Sreepriya, Nair, Tessy, Xavier, Madathiparambil Kumaran Satheesh, Kumar, Sharmistha, Saha, Krishnakumar N, Menon   +4 more
openaire   +2 more sources

Proteomic changes associated with degeneration of myelin‐forming cells in the central nervous system of c‐myc transgenic mice

ELECTROPHORESIS, 1998
AbstractMyelin is necessary for the conduction of high frequency and high velocity nerve impulses in the central nervous system of mammals, and severe neurological disturbances develop as a result of myelin loss. In this report, we have characterized changes in the brain proteomic profile of transgenic mice that develop a c‐myc‐induced degenerative ...
N A, Jensen, J E, Celis
openaire   +2 more sources

Effects of treadmill training on myelin proteomic markers and cerebellum morphology in a rat model of cuprizone-induced toxic demyelination

Journal of Neuroimmunology
Multiple sclerosis (MS) is the most common demyelinating disease of the central nervous system (CNS). If demyelination is persistent, it will result in irreversible axonal injury and loss. The purpose of the current study was to investigate the effects of treadmill training on myelin proteomic markers and cerebellum morphology in a rat model of ...
Alireza, Lotfi, Maryam, Abbasi, Nasrin, Karami, Hadis, Arghavanfar, Fatemeh, Kazeminasab, Sara K, Rosenkranz   +5 more
openaire   +2 more sources