Results 171 to 180 of about 13,038 (207)
Spatiotemporal multi-omics atlas of the aging neuromuscular junction
Amoretti S +9 more
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Proteomic Mapping of the Human Myelin Proteome
, 2021 Alzheimer's disease (AD) is a degenerative cognitive condition that affects individuals with an increasing prevalence in older age groups. There are currently five drugs on the market for AD but no new effective ones have been discovered for decades.
Paul C. Guest
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Myelin: Methods for Purification and Proteome Analysis [PDF]
, 2019 Molecular characterization of myelin is a prerequisite for understanding the normal structure of the axon/myelin-unit in the healthy nervous system and abnormalities in myelin-related disorders. However, reliable molecular profiles necessitate very pure myelin membranes, in particular when considering the power of highly sensitive "omics"-data ...
Michelle S Erwig +7 more
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Myelin Proteome Analysis: Methods and Implications for the Myelin Cytoskeleton
, 2012 Myelin, the multilayered membrane that enwraps and insulates neuronal axons for fast signal propagation, is a plasma membrane specialization of oligodendrocytes and Schwann cells in the central and peripheral nervous system, respectively. Here we provide our lab protocols for the puri fi cation of myelin from mouse brains and for gel-based and gel-free
Olaf Jahn +4 more
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New observations on the compact myelin proteome
Neuron Glia Biology, 2005 Myelin formation and maintenance depends on the establishment of two structurally and biochemically discernible domains: (a) compact myelin, that is multilamellar stacks of plasma membrane sheets; and (b) cytoplasmic channels that border the compact myelin domains, attach them to the cell body and anchor the myelin sheath to the axonal membrane.
Alejandro D. Roth +2 more
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Lipidome and proteome map of myelin membranes
Journal of Neuroscience Research, 2012 AbstractTo understand the molecular anatomy of myelin membranes, we performed a large‐scale, liquid chromatography‐coupled tandem mass spectrometry (LC‐MS/MS)‐based lipidome and proteome screen on freshly purified human and murine myelin fractions. We identified more than 700 lipid moieties and above 1,000 proteins in the two species, including 284 ...
Gopakumar Gopalakrishnan +6 more
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Functional degradation of myelin basic protein. The proteomic approach
Russian Journal of Bioorganic Chemistry, 2011Proteolytic degradation of autoantigens is of prime importance in current biochemistry and immunology. The most fundamental issue in this field is the functional role of peptides produced when the specificity of hydrolysis changes during the shift from health to disease and from normal state to pathology.
A V, Bacheva +7 more
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Proteomics Analysis of Myelin Composition
2018The identification and functional characterization of the repertoire of myelin proteins provides a valuable foundation for understanding molecular mechanisms of myelination and the pathogenesis of human myelin disease. Here we provide a procedure for the purification of myelin from rodent or human brains and a large-scale analysis of the myelin ...
Akihiro, Ishii +2 more
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Myelin proteomics: the past, the unexpected and the future
Expert Review of Proteomics, 2014Myelin proteomics has been the subject of intense research over the last decade, and its profiling has achieved good results by both in-gel and mass spectrometry-based techniques. 1280 proteins have been identified, a number expected to increase. Some of the identified proteins are as yet not established as true components of myelin.
I. Panfoli +6 more
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