Results 121 to 130 of about 48,712 (325)

AAV‐Based Intracerebral Administration of BDNF Promotes Myelin Repair and Cognitive Improvement After Cuprizone‐Induced Demyelination

Glia, EarlyView.
AAV‐BDNF improves cognitive performance after cuprizone‐induced de‐myelination. BDNF promotes OPC maturation and enhances remyelination in the corpus callosum. Mitochondrial integrity is preserved through reduced swelling and improved morphology. ABSTRACT Multiple sclerosis (MS) is a chronic neurological disorder involving immune‐mediated demyelination
Yousra El Ouaamari, Leonardo Ricciardi, Sanne van der Heijden, Antonia Peter, Jorrit De Waele, Jasper Van den Bos, Debby Van Dam, Elke Calus, Sarah Kuhn, Waleed Marei, Yvonne Dombrowski, Marleen Verhoye, Peter Ponsaerts, Inez Wens, Nathalie Cools   +14 more
wiley   +1 more source

FURTHER OBSERVATIONS ON THE STRUCTURE OF MYELIN SHEATHS IN THE CENTRAL NERVOUS SYSTEM [PDF]

, 1964
Alan Peters
openalex   +1 more source

Reduced Accumulation Rate and Morphological Changes of Newly Generated Myelinating Oligodendrocytes in the Corpus Callosum of Aged Mice

Glia, EarlyView.
Newly generated myelinating oligodendrocyte accumulation is decreased in the corpus callosum of aged mice. Morphological changes of newly generated myelinating oligodendrocytes in aged mice: greater height, shorter, and fewer myelin sheaths. ABSTRACT The activity of oligodendrocyte progenitor cells (OPCs) and oligodendrocytes (OLs) throughout life ...
Sasikarn Looprasertkul, Reiji Yamazaki, Yasuyuki Osanai, Nobuhiko Ohno   +3 more
wiley   +1 more source

Histological and Ultrastructure of the Peripheral Nerve in Cadaveric Embalmed Specimens and in Fresh Cadavers: the Efficacy of Several Fixatives

Siriraj Medical Journal, 2009
Objective: The study is to observe the histological structure and the ultrastructure of the peripheral nerve from cadaveric embalmed specimens and from fresh specimens by light microscope and by transmission electron microscope.
Kunnika Chatyingmongkol, Jantima Roongruangchai, Kesorn Sripaoraya   +2 more
doaj  

Formation of Compact Myelin Is Required for Maturation of the Axonal Cytoskeleton [PDF]

, 1999
Although traditional roles ascribed to myelinating glial cells are structural and supportive, the importance of compact myelin for proper functioning of the nervous system can be inferred from mutations in myelin proteins and neuropathologies associated ...
Brady, Scott T., de Waegh, Sylvie M., Kirkpatrick, Laura L., Lee, Virginia M.-Y., Readhead, Carol, Tu, Pang-Hsien, Witt, Andrea S.   +6 more
core  

Glia Preserve Their Own Functions While Compensating for Neighboring Glial Cell Dysfunction

Glia, EarlyView.
When cortex glia lose their interactions with neuronal cell bodies, all neighboring glia infiltrate the region to clear extra neuronal corpses. Even while compensating for nearby glial dysfunction, glia maintain their own phagocytic functions. ABSTRACT Glial cells are essential for nervous system development, homeostasis, and disease response, engaging
Allison N. Beachum, Gabriela Salazar, Amelia Nachbar, Kevin Krause, Hannah Klose, Kate Meyer, Ariana Maserejian, Grace Ross, Hannah Boyd, Thaddeus Weigel, Lydia Ambaye, Hayes Miller, Hannah Grote, Jaeda Coutinho‐Budd   +13 more
wiley   +1 more source

Macrophage Targeting Protects Nerve Structure and Improves Muscle Innervation in a Mouse Model of Charcot‐Marie‐Tooth 2J

Glia, EarlyView.
Hemizygous P0T124M mice develop a late‐onset axonopathy at 18 months of age. Pharmacological macrophage targeting with PLX5622 prevents distal axon degeneration in P0T124M mutant mice and mitigates motor impairment. ABSTRACT In several previous studies, we have shown that macrophage targeting with the CSF‐1 receptor specific kinase (c‐FMS) inhibitor ...
Dennis Klein, Neslim Ercan, Xidi Yuan, Ghjuvan' Ghjacumu Shackleford, Anke Claessens, M. Laura Feltri, Lawrence Wrabetz, Maurizio D'Antonio, Rudolf Martini   +8 more
wiley   +1 more source

Researcher studies nervous system development [PDF]

, 2016
Ashley Purdy, who recently finished a master’s degree in biology at VCU and is now pursuing her Ph.D., is studying nerve cells in zebrafish in hopes of unlocking secrets about the human nervous system.
Bellamy, Paige
core   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Characterization of the axon initial segment (AIS) of motor neurons and identification of a para-AIS and a juxtapara-AIS, organized by protein 4.1B

BMC Biology, 2011
Background The axon initial segment (AIS) plays a crucial role: it is the site where neurons initiate their electrical outputs. Its composition in terms of voltage-gated sodium (Nav) and voltage-gated potassium (Kv) channels, as well as its length and ...
Giovannini Marco, Chareyre Fabrice, Duflocq Amandine, Couraud François, Davenne Marc   +4 more
doaj   +1 more source