Results 121 to 130 of about 201,896 (346)
Exploration, EarlyView.Schematic illustration of structural and functional biomimicry. The upper part shows BP with various structures such as monolayered, surface‐microstructural, bilayered and multilayered. The bottom part exhibits BP with different functions including immune regulation, drugs/cells/factors/ions loading, as well as bioelectrical stimulation and ...
Yuhan Du +7 more
wiley +1 more source
Exploration, EarlyView.Targeting mitochondrial dysfunction presents a potential therapeutic approach for treating spinal cord injury. We have successfully designed and synthesized a functional Se@NADH nanodrug system. This system offers neuroprotective and neuroregenerative benefits by modulating mitochondrial function and neutralizing reactive oxygen species, thereby ...
Guibin Gao +12 more
wiley +1 more source
Towards in vivo g-ratio mapping using MRI: unifying myelin and diffusion imaging [PDF]
arXiv, 2020 The g-ratio, quantifying the comparative thickness of the myelin sheath encasing an axon, is a geometrical invariant that has high functional relevance because of its importance in determining neuronal conduction velocity. Advances in MRI data acquisition and signal modelling have put in vivo mapping of the g-ratio, across the entire white matter ...
arxiv
Cholinergic and Glutamatergic Axons Differentially Require Glial Support in the Drosophila PNS
Glia, EarlyView.In the Drosophila PNS, motor‐ and sensory axons (magenta, green) differentially interact with wrapping glial processes. Sensory axons are more weakly associated with wrapping glia and show a length‐dependent degeneration upon loss of wrapping glia.
Steffen Kautzmann +3 more
wiley +1 more source
Intrinsic dynamical fluctuations of PNS myelin [PDF]
arXiv, 2017 The ultrastructure fluctuations and complex dynamics of the multi-layered membrane structure of myelin are fundamental for understanding and control its formation process and its degeneration and repair in neurological diseases such as multiple sclerosis (MS).
arxiv
Tumor microenvironment (Part I): Tissue integrity in a rat model of peripheral neural cancer [PDF]
Heliyon, Volume 10, Issue 13, e33932, July 15, 2024ICAM-1 (intercellular adhesion molecule 1) and MPZ (myelin protein zero) are thought to be a factor in the integrity of nerve tissues. In this report, we attempted to trace the expression of ICAM-1, responsible for cell-to-cell adhesion, and of MPZ, the main constituent of myelin sheath, in malignant tissues of the sciatic nerve (SN) in inbred male ...
arxiv +1 more source
Glia, EarlyView.Ablation of autophagy in oligodendrocytes reveals increased PLP expression, myelin abnormalities, axon degeneration, and increased microglia activation in aged mice. The aged mice exhibit marked deficits in learning and memory tasks. ABSTRACT The aging central nervous system (CNS) is often marked by myelin degeneration, yet the underlying mechanisms ...
Niki Ktena +8 more
wiley +1 more source
Biology and postnatal development of organ systems of cynomolgus monkeys (Macaca fascicularis)
Journal of Medical Primatology, Volume 52, Issue 1, Page 64-78, February 2023., 2023 Abstract Background The cynomolgus macaque has become the most used non‐human primate species in nonclinical safety assessment during the past decades. Methods This review summarizes the biological data and organ system development milestones of the cynomolgus macaque available in the literature.
Xiantang Li +5 more
wiley +1 more source
Promise and pitfalls of g-ratio estimation with MRI [PDF]
, 2017 The fiber g-ratio is the ratio of the inner to the outer diameter of the myelin sheath of a myelinated axon. It has a limited dynamic range in healthy white matter, as it is optimized for speed of signal conduction, cellular energetics, and spatial constraints. In vivo imaging of the g-ratio in health and disease would greatly increase our knowledge of
arxiv +1 more source
Glia, EarlyView.Amyloid‐β peptide induces early oligodendrocyte differentiation and dorsal myelination in the zebrafish larvae spinal cord. Pan‐PKC inhibitor Gö6983 restores the aforementioned alterations in oligodendrocytes and myelin. ABSTRACT Soluble forms of amyloid‐β (Aβ) peptide have been proposed as candidates to induce oligodendrocyte (OL) and myelin ...
Uxue Balantzategi +7 more
wiley +1 more source