Results 151 to 160 of about 48,603 (346)

Specific Iron Binding to Natural Sphingomyelin Membrane Induced by Non-Specific Co-Solutes [PDF]

Hypothesis: Sphingomyelin (SPM), a crucial phospholipid in the myelin sheath, is vital in insulating nerve fibers. We hypothesize that iron ions selectively bind to the phosphatidylcholine (PC) template within the SPM membrane under near-physiological conditions, disrupting membrane organization.
arxiv   +1 more source

Myelin sheath survival after guanethidine-induced axonal degeneration. [PDF]

, 1992
Grahame J. Kidd, John W. Heath, Bruce D. Trapp, Peter R. Dunkley   +3 more
openalex   +1 more source

Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu, Kyungdo Kim, Nicholas Asiimwe, Chan Hyun Na   +3 more
wiley   +1 more source

The Multiple Roles of Myelin Protein Genes During the Development of the Oligodendrocyte

ASN Neuro, 2009
It has become clear that the products of several of the earliest identified myelin protein genes perform functions that extend beyond the myelin sheath. Interestingly, these myelin proteins, which comprise proteolipid protein, 2′, 3′-cyclic nucleotide 3′-
Daniel Fulton, Pablo M Paez, Anthony T Campagnoni   +2 more
doaj   +1 more source

The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration. [PDF]

Mol Med, 2023
Xu J, Zhang B, Cai J, Peng Q, Hu J, Askar P, Shangguan J, Su W, Zhu C, Sun H, Zhou S, Chen G, Yang X, Gu Y.   +13 more
europepmc   +1 more source

Myelin dysfunction/degradation in the central nervous system: why are myelin sheaths susceptible to damage? [PDF]

, 1999
Monika Bradl
openalex   +1 more source

Mitochondrial dynamics in autoimmune diseases

Rheumatology &Autoimmunity, EarlyView.
Roles of mitochondrial dynamic imbalance in autoimmune diseases. The imbalance of mitochondrial fusion and fission is involved in the occurrence and development of autoimmune diseases, including systemic lupus erythematosus, Sjogren's syndrome, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, type 1 diabetes, psoriasis, and autoimmune ...
Ruicong Ma, Cheng Zhang, Jiaqing Liu, Jinyi Ren, Xia Li, Ying Zhao   +5 more
wiley   +1 more source

Bioinformatics analysis of myelin-microbe interactions suggests multiple types of molecular mimicry in the pathogenesis of multiple sclerosis.

PLoS ONE
Multiple sclerosis (MS) is a devastating autoimmune disease that leads to the destruction of the myelin sheath in the human central nervous system (CNS).
Ali Bigdeli, Mostafa Ghaderi-Zefrehei, Bluma J Lesch, Mehrdad Behmanesh, S Shahriar Arab   +4 more
doaj   +1 more source

Finite-Difference Time-Domain Simulation for Three-dimensional Polarized Light Imaging

, 2016
Three-dimensional Polarized Light Imaging (3D-PLI) is a promising technique to reconstruct the nerve fiber architecture of human post-mortem brains from birefringence measurements of histological brain sections with micrometer resolution.
A Taflove, AM Glazer, GF Göthlin, H Raedt De, KS Yee, M Axer, M Axer, M Dohmen, M Menzel, M Stephan, O Sporns, RC Jones, RC Jones, RS Bear, TEJ Behrens   +14 more
core   +1 more source

Functional Gap Junctions in the Schwann Cell Myelin Sheath [PDF]

, 1998
Rita J. Balice‐Gordon, Linda Jo Bone, Steven S. Scherer   +2 more
openalex   +1 more source