Cdc42 and Rac1 Signaling Are Both Required for and Act Synergistically in the Correct Formation of Myelin Sheaths in the CNS [PDF]
, 2006 Tina Buerki‐Thurnherr +9 more
openalex +1 more source
Proteomic Insight Into Alzheimer's Disease Pathogenesis Pathways
PROTEOMICS, EarlyView.ABSTRACT Alzheimer's disease (AD) is a leading cause of dementia, but the pathogenesis mechanism is still elusive. Advances in proteomics have uncovered key molecular mechanisms underlying AD, revealing a complex network of dysregulated pathways, including amyloid metabolism, tau pathology, apolipoprotein E (APOE), protein degradation ...
Taekyung Ryu +3 more
wiley +1 more source
6 4 Integrin and Dystroglycan Cooperate to Stabilize the Myelin Sheath [PDF]
, 2008 Alessandro Nodari +12 more
openalex +1 more source
Mathematical Modeling of Neuroinflammation in Neurodegenerative Diseases
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Age‐related neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), Alzheimer's disease (AD) and Parkinson's disease (PD) are an increasing public health concern. Whereas the pathology of these diseases is complex, chronic central inflammation, or neuroinflammation, is commonly observed across many neurodegenerative diseases ...
Alex Foster‐Powell +4 more
wiley +1 more source
Modified FGF Hydrogel for Effective Axon Formation by Enhanced Regeneration of Myelin Sheath of Schwann Cells Using Rat Model. [PDF]
Int J Nanomedicine, 2023 Li J +5 more
europepmc +1 more source
Dysregulation of NAD+ metabolism induces a Schwann cell dedifferentiation program [PDF]
, 2018 The Schwann cell (SC) is the major component of the peripheral nervous system (PNS) that provides metabolic and functional support for peripheral axons. The emerging roles of SC mitochondrial function for PNS development and axonal stability indicate the
Hackett, Amber R +4 more
core +1 more source
State‐of‐the‐Art on Model‐Informed Drug Development Approaches for Pediatric Rare Diseases
CPT: Pharmacometrics &Systems Pharmacology, EarlyView.ABSTRACT Pediatric rare diseases present unique challenges for drug development due to small patient populations, ethical constraints on clinical trial design, and limited prospectively defined natural history data. Model‐Informed Drug Development (MIDD) has emerged as a powerful paradigm to address these challenges by leveraging quantitative methods ...
Rajesh Krishna +4 more
wiley +1 more source
FEBS Open BioAlzheimer's disease (AD) is the most common cause of dementia. A genome‐wide association study has shown that several AD risk genes are involved in lipid metabolism.
Noe Kawade, Koji Yamanaka
doaj +1 more source
The transcription factor Stat-1 is essential for Schwann cell differentiation, myelination and myelin sheath regeneration. [PDF]
Mol Med, 2023 Xu J +13 more
europepmc +1 more source